Laboratory Investigation - Table of Contents alert Volume 95 Issue 4

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TABLE OF CONTENTS Volume 95, Issue 4 (April 2015) In this issue Inside the USCAP Journals Pathobiology in Focus Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2015 95: 364-365; 10.1038/labinvest.2015.42 Full Text Pathobiology in Focus Top Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images This review focuses on developments in quantitative imaging technologies and integration of image features with genomic and clinical data leading to a more comprehensive and objective classification of tumor subtypes. Lee AD Cooper, Jun Kong, David A Gutman, William D Dunn, Michael Nalisnik and Daniel J Brat 2015 95: 366-376; advance online publication, January 19, 2015; 10.1038/labinvest.2014.153 Abstract | Full Text Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology Quantifying the spatial context of the tumor microenvironment is key for unravelling the complexity of cancer. Inter-disciplinary approaches are required to overcome this challenge. This review sheds light on recent developments that analyze the tumor microenvironment using joint techniques such as molecular profiling, image processing and spatial statistics. Andreas Heindl, Sidra Nawaz and Yinyin Yuan 2015 95: 377-384; advance online publication, January 19, 2015; 10.1038/labinvest.2014.155 Abstract | Full Text Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic This review describes methods for visualization and quantification of biomarkers (protein and mRNA) in tissue. The authors then consider the challenges in bringing quantitative tissue biomarkers to the clinic. Daniel E Carvajal-Hausdorf, Kurt A Schalper, Veronique M Neumeister and David L Rimm 2015 95: 385-396; advance online publication, December 15, 2014; 10.1038/labinvest.2014.157 Abstract | Full Text Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging Multiplexing in FFPE-tissues is possible using a combination of metal-labelled antibodies and scanning mass spectrometry. Numerous targets can be visualized simultaneously, with spatial resolution as good as or better than conventional light microscopy. Complex diagnostic panels can be deployed without encountering issues related to slide-to-slide correlation or insufficient samples. Richard M Levenson, Alexander D Borowsky and Michael Angelo 2015 95: 397-405; advance online publication, March 2, 2015; 10.1038/labinvest.2015.2 Abstract | Full Text Classification of malignant and benign tumors of the lung by infrared spectral histopathology (SHP) Spectral histopathology (SHP) is a label-free, instrument-based and fully reproducible method for the classification of histological samples. SHP utilizes chemical compositional changes, rather than morphology, for classification. We report the accuracy obtained using SHP from a large cohort of lung cancer samples. Ali Akalin, Xinying Mu, Mark A Kon, Ayşegül Ergin, Stan H Remiszewski, Clay M Thompson, Dan J Raz and Max Diem 2015 95: 406-421; advance online publication, February 9, 2015; 10.1038/labinvest.2015.1 Abstract | Full Text MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice Imaging mass spectrometry (IMS) is a novel tissue based research tool that maps the distribution of multiple analytes directly with histological features. Several applications of IMS are discussed such as tissue based disease classification, tumoral heterogeneity, therapy response and prognosis. Michaela Aichler and Axel Walch 2015 95: 422-431; advance online publication, January 26, 2015; 10.1038/labinvest.2014.156 Abstract | Full Text Application of GFP imaging in cancer Green fluorescent protein (GFP) technology allows is a non-invasive method that allows for the visualization of cells and their components both in-vivo and in tissue culture. This review focuses on advances in utilizing this technology in cancer research such as tracking metastatic disease and determination of the efficacy of tumor therapy in murine models. Robert M Hoffman 2015 95: 432-452; advance online publication, February 16, 2015; 10.1038/labinvest.2014.154 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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