Nature Reviews Neuroscience contents April 2015 Volume 16 Number 4 pp 185-244

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TABLE OF CONTENTS
April 2015 Volume 16 Number 4
Impact Factor 31.376 *	In this issue Research Highlights Reviews Correspondence Perspectives Also this month Article series: Stress Also this month  Featured article: Determining the role of microRNAs in psychiatric disorders Orna Issler & Alon Chen
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Animation: Depression and its treatment In this animation from Nature Neuroscience, we explore the circuits affected in depression, and illustrate the molecular and cellular changes thought to underlie the effects of chronic stress and its remediation by antidepressant drugs.  Access the Animation free online.  Produced with support from: Janssen
RESEARCH HIGHLIGHTS Top Neuropharmacology: Driving the urge to eat p185 | doi:10.1038/nrn3940 Cannabinoids promote food intake in mice by activating pro-opiomelanocortin neurons in the hypothalamus and selectively increasing β-endorphin release. PDF Gene expression: Putting a stop to BDNF p186 | doi:10.1038/nrn3933 Chronic morphine treatment reduces brain-derived neurotrophic factor (Bdnf) expression by influencing various epigenetic mechanisms, including histone modification and reduced transcription factor binding to Bdnf. PDF Glia: Anchored at the axon p186 | doi:10.1038/nrn3934 A subset of perineuronal satellite microglia interact specifically with the axon initial segment in a subpopulation of cortical neurons. PDF Pain: Turning down the heat in pain p187 | doi:10.1038/nrn3938 The GABA receptor subunit GABAB1 inhibits sensitization of the heat-activated transient receptor potential cation channel TRPV1 in peripheral nociceptors. PDF Psychiatric disorders: A zebrafish model of ADHD p188 | doi:10.1038/nrn3936 Per1b-mutant zebrafish exhibit symptoms that mimic those of attention-deficit hyperactivity disorder and can be used to provide insight into the pathogenic disease mechanisms. PDF IN BRIEF Neural circuits: Freeze — you're under arrest | Neurodegenerative disease: Tau brings the network down | Sensory processing: Whiskers of a good friend | Neural development: Expanding horizons PDF Neuroscience JOBS of the week Postdoctoral fellow - developmental neurobiology State University of New York PhD Position - In-vivo Neurophysiology Werner Reichardt Centre for Integrative Neurocience Research Associate University College London (UCL) Neurobiologist and Cell Biologist Rutgers University - New Brunswick Postdoctoral Fellow University of Michigan Ann Arbor More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium – Perspectives on Social Behaviour 16.09.15 Lisbon, Portugal More science events from
REVIEWS		Top
Article series: Stress Molecular mechanisms in the regulation of adult neurogenesis during stress Martin Egeland, Patricia A. Zunszain & Carmine M. Pariante p189 | doi:10.1038/nrn3855 In this Review, Egeland, Zunszain and Pariante examine the complicated relationship between the stress response and adult neurogenesis, which can regulate each other. They discuss the molecular pathways that may underlie this interaction in the dentate gyrus. Abstract | Full Text | PDF
Determining the role of microRNAs in psychiatric disorders Orna Issler & Alon Chen p201 | doi:10.1038/nrn3879 Several psychiatric disorders have been linked to changes in microRNA levels in the circulation and brain. In this Review, Issler and Chen discuss approaches for studying the role of these non-coding RNAs in disease and highlight examples of their potential pathophysiological contributions to psychiatric disorders. Abstract | Full Text | PDF
The neuroscience of mindfulness meditation Yi-Yuan Tang, Britta K. Hölzel & Michael I. Posner p213 | doi:10.1038/nrn3916 Positive effects of mindfulness-based practices on health and cognitive performance have been reported; however, we know little about the underlying mechanisms. Tang and colleagues outline the challenges of meditation research and consider emerging information about the effects of mindfulness meditation on brain structure and function. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Visual attention deficits in developmental dyslexia cannot be ascribed solely to poor reading experience Muriel Lobier & Sylviane Valdois p225 | doi:10.1038/nrn3836-c1 Full Text | PDF
Visual attention span deficits and assessing causality in developmental dyslexia Usha Goswami p225 | doi:10.1038/nrn3836-c2 Full Text | PDF
PERSPECTIVES		Top
OPINION Disentangling calcium-driven astrocyte physiology Dmitri A. Rusakov p226 | doi:10.1038/nrn3878 How fast and precise is astrocytic Ca2+ signalling? In this Opinion article, Dmitri Rusakov discusses how overcoming difficulties in monitoring and interpreting astrocyte Ca2+ signalling — and the acquisition of a fuller understanding — requires a leap in our experimental and analytical strategies. Abstract | Full Text | PDF
OPINION Illiterate to literate: behavioural and cerebral changes induced by reading acquisition Stanislas Dehaene, Laurent Cohen, José Morais & Régine Kolinsky p234 | doi:10.1038/nrn3924 Reading enables language to be perceived through vision. In this Opinion article, Dehaene and colleagues discuss the changes in brain function, brain structures and behaviour that occur when learning how to read, and how these changes may reflect more-efficient connections among visual and language-processing centres. Abstract | Full Text | PDF
Erratum: Spatial cognition in bats and rats: from sensory acquisition to multiscale maps and navigation Maya Geva-Sagiv, Liora Las, Yossi Yovel & Nachum Ulanovsky p244 | doi:10.1038/nrn3931 Full Text | PDF
Erratum: Retromer in Alzheimer disease, Parkinson disease and other neurological disorders Scott A. Small & Gregory A. Petsko p244 | doi:10.1038/nrn3935 Full Text | PDF
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