Nature Reviews Molecular Cell Biology contents April 2015 Volume 16 Number 4 pp 203-264

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TABLE OF CONTENTS
April 2015 Volume 16 Number 4
Impact Factor 36.458 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications  Featured article: Diversity and selectivity in mRNA translation on the endoplasmic reticulum David W. Reid & Christopher V. Nicchitta
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RESEARCH HIGHLIGHTS Top Genome instability: Targeted telomere insertion p203 | doi:10.1038/nrm3969 In cells that use alternative lengthening of telomeres (ALT), NR2C/F proteins mediate the insertion of telomeric DNA throughout the genome and hence genome instability. PDF Development: Switching off WNT with precision p204 | doi:10.1038/nrm3971 Notum switches off WNT signalling by removing a palmitoleate moiety from WNT proteins that is essential for receptor binding. PDF Lipid metabolism: Fatty acids on the move p204 | doi:10.1038/nrm3972 This study shows that, during starvation, fatty acids are released from lipid droplets by lipolysis and taken up by fused mitochondria to support oxidative respiration. PDF JOURNAL CLUB LOV is all we need p206 | doi:10.1038/nrm3950 Robert Grosse discusses how optogenetic strategies have the potential to advance our understanding of protein function and localization in individual living cells. PDF Non-coding RNA: Circular RNAs promote transcription p206 | doi:10.1038/nrm3967 Exon-intron circular RNAs are a new subclass of non-coding RNAs that interact specifically with the U1 snRNP to promote gene transcription in cis. PDF IN BRIEF Cell signalling: When signals cross | RNA metabolism: m6A modulates RNA structure | DNA replication: Double duty for ATR | Transcription: A novel termination pathway | Stem cells: Linking stemness to low DNA damage | Protein metabolism: Get3 hides transmembrane domains in its pocket PDF Molecular Cell Biology JOBS of the week PhD student A*STAR Institute of Molecular and Cell Biology (IMCB) Post doc IGBMC, Institute of Genetics and Molecular and Cellular Biology Postdoctoral Fellow University of Arizona Associate Professional Specialist Princeton University More Science jobs from Molecular Cell Biology EVENT Next-Generation Antibodies and Protein Analysis: Tools and Technologies 15.06.15 Gent, Belgium More science events from
REVIEWS		Top
Replication fork reversal in eukaryotes: from dead end to dynamic response Kai J. Neelsen & Massimo Lopes p207 | doi:10.1038/nrm3935 Replication perturbation causes replication fork reversal (remodelling). Recent studies have visualized replication forks in metazoan cells and identified fork remodelling factors, showing fork reversal to be a global and regulated process with potential effects on replication termination, genome stability and the DNA damage response. Abstract | Full Text | PDF | Supplementary information
Diversity and selectivity in mRNA translation on the endoplasmic reticulum David W. Reid & Christopher V. Nicchitta p221 | doi:10.1038/nrm3958 Recent studies of mRNA distribution and translation show that, in addition to serving as the site of protein translocation into the endoplasmic reticulum (ER), ER-bound ribosomes translate a large fraction of mRNAs that encode cytosolic proteins. This, along with the discovery of many mechanisms for recruiting translation to the ER, suggests an expansive role for the ER in post-transcriptional gene expression. Abstract | Full Text | PDF
Signalling scaffolds and local organization of cellular behaviour Lorene K. Langeberg & John D. Scott p232 | doi:10.1038/nrm3966 Recent technical advances have shown that scaffold proteins can hold members of a signal transduction cascade in place, focus enzyme activity at a particular site of action and/or provide a structural platform for the recruitment of signal transduction and signal termination enzymes. Abstract | Full Text | PDF
Three-dimensional genome architecture: players and mechanisms Ana Pombo & Niall Dillon p245 | doi:10.1038/nrm3965 Genome-wide mapping of chromatin contacts reveals the structural and organizational changes that the metazoan genome undergoes during cell differentiation. These changes involve entire chromosomes, which are influenced by contacts with nuclear structures such as the lamina, and local interactions mediated by transcription factors and chromatin looping. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE Article series: Post-translational modifications 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond Eric Verdin & Melanie Ott p258 | doi:10.1038/nrm3931 The year 2014 marks the 50th anniversary of the discovery of protein acetylation. In this Timeline article, Verdin and Ott discuss the identification of this modification, of its regulatory enzymes and of the roles of acetylation in transcription and other cellular processes, and provide an outlook on the future of the field. Abstract | Full Text | PDF
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