Nature Reviews Immunology Contents April 2015 Volume 15 Number 4 pp 199-263

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TABLE OF CONTENTS
April 2015 Volume 15 Number 4
Impact Factor 33.836 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The role of sex hormones in immune protection of the female reproductive tract Charles R. Wira, Marta Rodriguez-Garcia & Mickey V.Patel
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FOCUS on: Immunology of the lung A series of Reviews and an animation specially commissioned by Nature Immunology explore the immunology of the lungs.  Access is available free online.  Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson
RESEARCH HIGHLIGHTS Top Inflammasome: Starving inflammation p199 | doi:10.1038/nri3832 Two potent inhibitors of the NLRP3 inflammasome have been identified — a drug called MCC950 and the exercise- or fasting-induced metabolite β-hydroxybutyrate. PDF Mucosal immunology: Food additives feed the fire p200 | doi:10.1038/nri3833 Emulsifying agents found in food may contribute to colitis and metabolic syndrome by disrupting the intestinal microbiota. PDF In the news p200 | doi:10.1038/nri3838 PDF Neutrophils: New sensor of bacterial DNA p200 | doi:10.1038/nri3840 The transcription factor SOX2 detects bacterial DNA in neutrophils, which leads to the activation of pro-inflammatory cytokines. PDF Antibacterial immunity: A pinch of salt p202 | doi:10.1038/nri3835 High levels of salt in the skin promote the antibacterial defences of macrophages. PDF HIV: On the road to an HIV vaccine? p202 | doi:10.1038/nri3836 A new construct termed eCD4-Ig neutralizes all tested HIV isolates and protects macaques from multiple SHIV challenges. PDF IN BRIEF Neonatal immunity: Fetal immune repertoire | Neuroimmunology: TREM2 in Alzheimer disease PDF Immunology JOBS of the week Faculty Positions in Immunology : Nanjing, China Nanjing Medical University Tenure-Track Immunology (Tumor) Faculty Position University of Connecticut Health Center Postdoctoral Fellow-Translational Tumor Immunology Program The Wistar Institute Postdoctoral Scientist Cancer Immune Biology (m/f) Boehringer Ingelheim T Cell Immunologist Université Libre de Bruxelles (ULB) More Science jobs from Immunology EVENT Nutritional Immunology: Role in Health and Disease 26.07.15 Lisbon, Portugal More science events from
REVIEWS		Top
The ins and outs of MHC class II-mediated antigen processing and presentation Paul A. Roche & Kazuyuki Furuta p203 | doi:10.1038/nri3818 To play their part in the generation of effective adaptive immune responses, different types of antigen-presenting cell (APC) take up and process antigen in different ways. The length of time that peptide-MHC class II complexes are present on APC surfaces can also vary depending on the cell type. This Review describes the different modes and mechanisms that regulate MHC class II processing and presentation. Abstract | Full Text | PDF
The role of sex hormones in immune protection of the female reproductive tract Charles R. Wira, Marta Rodriguez-Garcia & Mickey V. Patel p217 | doi:10.1038/nri3819 Regulation of the immune response in the female reproductive tract by sex hormones enables optimal conditions for fertilization and pregnancy according to the stage of the menstrual cycle, but can simultaneously affect susceptibility to pathogen infection. Abstract | Full Text | PDF
Regulation of antiviral T cell responses by type I interferons Josh Crouse, Ulrich Kalinke & Annette Oxenius p231 | doi:10.1038/nri3806 Type I interferons (IFNs) have both direct and indirect effects on T cells, and can promote or inhibit their antiviral activity. As reviewed here, the outcome of type I IFN signalling in T cells largely depends on the timing of the signal relative to T cell receptor activation. Abstract | Full Text | PDF
Balancing natural killer cell activation through paired receptors Ludovic Martinet & Mark J. Smyth p243 | doi:10.1038/nri3799 A recently identified family of molecules that bind nectin and nectin-like proteins is proving to be important in the regulation of natural killer cell functions. As reviewed here, increased understanding of the activity and signalling pathways of these proteins implicates them as potential targets for the treatment of cancer, autoimmunity and viral infection. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Advancing host-directed therapy for tuberculosis Robert S. Wallis & Richard Hafner p255 | doi:10.1038/nri3813 Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive agents that target the host have the potential to shorten treatment duration, prevent resistance and reduce lung injury by promoting macrophage effector mechanisms and blocking mechanisms that cause lung destruction. Abstract | Full Text | PDF
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Multicolor flow cytometry How have the advances of modern multicolor flow cytometry driven research forward, especially in the field of immunology?  Access this Collection from Nature Immunology free online.   Produced with support from: BD Biosciences
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