Nature Immunology Contents: April 2015 Volume 16 pp 327 - 433

If you are unable to see the message below, click here to view.

Advertisement Rapid apoptosis analysis. Affordable, simple instrumentation. Muse™ Cell Analyzer.  The Muse™ cell analyzer uses convenient assays to detect the differential markers of apoptosis including caspase activation, mitochondrial membrane potential change, and Annexin V staining. The power of 3-parameter flow cytometry means reliable, quantitative results on your benchtop. TABLE OF CONTENTS April 2015 Volume 16, Issue 4 Editorial Commentary News and Views Research Highlights Review Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Innovations in the Microbiome Tending the garden within Can good microbes improve our health? Does our gut govern the state of our mind? Can smart bacteria treat disease? Answer these questions and more in Innovations in the Microbiome Produced with support from Nestlé   Editorial Top Announcement: double-blind peer review   p327 doi:10.1038/ni.3129 Nature and its sister journals start offering anonymity to authors during the peer-review process. Commentary Top Immune mechanisms at the maternal-fetal interface: perspectives and challenges   pp328 - 334 Mercy PrabhuDas, Elizabeth Bonney, Kathleen Caron, Sudhansu Dey, Adrian Erlebacher et al. doi:10.1038/ni.3131 Leaders gathered at the US National Institutes of Health in November 2014 to discuss recent advances and emerging research areas in aspects of maternal-fetal immunity that may affect fetal development and pregnancy success. News and Views Top Sox2 as a servant of two masters   pp335 - 336 Arun K Mankan and Veit Hornung doi:10.1038/ni.3121 The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling cascade dependent on the kinase TAK1 and adaptor TAB2 that culminates in the expression of genes encoding pro-inflammatory molecules. See also: Article by Xia et al. Thymic IL-7 signaling goes beyond survival   pp337 - 338 Benedict Seddon doi:10.1038/ni.3128 Interleukin 7 (IL-7) promotes the self-renewing ability of CD4- CD8- double-negative thymocytes by both supporting cell growth and repressing rearrangements of the locus encoding the T cell antigen receptor (TCR). See also: Article by Boudil et al. The lymph node filter revealed   pp338 - 340 Miroslav Hons and Michael Sixt doi:10.1038/ni.3126 Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP is a crucial component of this selector function. See also: Article by Rantakari et al. A new receptor for LPS   pp340 - 341 Cyril Zipfel doi:10.1038/ni.3127 A surface-localized lectin S-domain receptor kinase confers recognition of lipopolysaccharide in plants. See also: Article by Ranf et al. Immunology JOBS of the week Postdoc Position in Immunology New York University School of Medicine (NYU School of Medicine) Post-Doctoral position in immunology Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Postdoctoral Fellowship-Immunology Moffitt Cancer Center & Research Institute Faculty Positions in Immunology Dana-Farber Cancer Institute and Harvard Medical School Tenure-Track Faculty Positions In Immunology Weill Cornell College of Medicine More Science jobs from Immunology EVENT Nutritional Immunology: Role in Health and Disease 26th July - 31st July 2015 Lisbon, Portugal More science events from Research Highlights Top NLRP3 shapes immunity to Leishmania | Blocking viral maturation | Recruiting IRF3 | Stressed HSCs | Suppressive ketone | Resolving Mer actions Review Top Control of adaptive immunity by the innate immune system   pp343 - 353 Akiko Iwasaki and Ruslan Medzhitov doi:10.1038/ni.3123 Iwasaki and Mezhitov provide an update of their classic 2004 Review looking at the control of adaptive immunity by the innate immune system Advertisement The ChemiDoc™ Touch Imaging System from Bio-Rad Get the quantitation of digital imaging with the sensitivity of film. Introducing the ChemiDoc™ Touch Imaging System, the latest addition to the V3 Western Workflow™. By providing optimal exposure for all samples and detecting signals distributed over a much broader range than film, the ChemiDoc Touch Imager ensures the quality and reproducibility of your western blotting results. See performance data.    Articles Top IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction   pp354 - 365 Claudia A Nold-Petry, Camden Y Lo, Ina Rudloff, Kirstin D Elgass, Suzhao Li et al. doi:10.1038/ni.3103 IL-37 is a member of the IL-1 family with profound anti-inflammatory functions. Nold and colleagues identify the receptor for IL-37 and clarify the molecular nature of the anti-inflammatory pathway induced by this cytokine. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection   pp366 - 375 Pengyan Xia, Shuo Wang, Buqing Ye, Ying Du, Guanling Huang et al. doi:10.1038/ni.3117 Fan and colleagues show that Sox2, already known to function as a transcription factor that controls lineage specification during embryogenesis, also has a role as a cytosolic and sequence-specific sensor of bacterial DNA in neutrophils. See also: News and Views by Mankan & Hornung NK cells link obesity-induced adipose stress to inflammation and insulin resistance   pp376 - 385 Felix M Wensveen, Vedrana Jelenčić, Sonja Valentić, Marko Šestan, Tamara Turk Wensveen et al. doi:10.1038/ni.3120 Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polic and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ. The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes   pp386 - 396 Pia Rantakari, Kaisa Auvinen, Norma Jäppinen, Maria Kapraali, Joona Valtonen et al. doi:10.1038/ni.3101 PLVAP is a blood vessel endothelium marker of uncertain function. Salmi and colleagues demonstrate that PLVAP is also expressed on lymphoid endothelial cells, where it regulates the entry of antigen and lymphocytes into the lymph nodes. See also: News and Views by Hons & Sixt IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection   pp397 - 405 Amine Boudil, Irina R Matei, Han-Yu Shih, Goce Bogdanoski, Julie S Yuan et al. doi:10.1038/ni.3122 IL-7 is known to control the survival of immature DN thymocytes before β-selection. Guidos and colleagues show that during β-selection, IL-7 controls the growth and differentiation of thymocytes, in part by repressing the transcription factor Bcl-6. See also: News and Views by Seddon Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection   pp406 - 414 Tessa Bergsbaken and Michael J Bevan doi:10.1038/ni.3108 Tissue-resident memory T cells (TRM cells) provide rapid frontline protection from reinfection. Bergsbaken and Bevan identify a gut TRM cell population generated via an unconventional pathway that is protective against a natural mouse intestinal pathogen. The RNA-binding protein HuR is essential for the B cell antibody response   pp415 - 425 Manuel D Diaz-Muñoz, Sarah E Bell, Kirsten Fairfax, Elisa Monzon-Casanova, Adam F Cunningham et al. doi:10.1038/ni.3115 The RNA-binding protein HuR post-transcriptionally regulates mRNA stability. Turner and colleagues demonstrate that HuR serves a critical role in thymus-independent antigen responses by regulating the fate of genes related to B cell energy use. A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana   pp426 - 433 Stefanie Ranf, Nicolas Gisch, Milena Schäffer, Tina Illig, Lore Westphal et al. doi:10.1038/ni.3124 Plants have a vast array of pattern-recognition receptor to detect microbial ligands, but how they sense lipopolysaccharide has remained unknown. Ranf et al. identify the receptor-like kinase SD1-29 as a de facto pattern-recognition receptor for lipopolysaccharide in Arabidopsis. See also: News and Views by Zipfel Top Advertisement Multicolor flow cytometry How have the advances of modern multicolor flow cytometry driven research forward, especially in the field of immunology?  Access this Collection from Nature Immunology free online.  Produced with support from: BD Biosciences      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.