Molecular Systems Biology - New articles published - 10 Mar 2015

February 2015 | Volume 11, Number 2 Submit Table of Contents Articles Reviews Volume 11, Number 2 Articles Quantitative variability of 342 plasma proteins in a human twin population The degree and origins of the abundance variability of 342 human plasma proteins are analyzed by a longitudinal twin design and SWATH mass spectrometry. The results suggest genetic control and longitudinal variation affect protein levels and biological processes to different degrees. Yansheng Liu, Alfonso Buil, Ben C Collins, Ludovic CJ Gillet, Lorenz C Blum, Lin‐Yang Cheng, Olga Vitek, Jeppe Mouritsen, Genevieve Lachance, Tim D Spector, Emmanouil T Dermitzakis, and Ruedi Aebersold Published online 04.02.2015 The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA This study presents the global protein interactome of the human PYHIN proteins (AIM2, IFI16, IFIX, and MNDA) and defines IFIX as an antiviral factor and sensor of viral DNA. Benjamin A Diner, Tuo Li, Todd M Greco, Marni S Crow, John A Fuesler, Jennifer Wang, and Ileana M Cristea Published online 09.02.2015 Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria Quantitative relative and absolute protein abundance data allow the use of coarse‐graining analysis to reveal strategies of resource allocation by E. coli. A predictive, mathematical model of the proteome is constructed requiring only a few parameters. Sheng Hui, Josh M Silverman, Stephen S Chen, David W Erickson, Markus Basan, Jilong Wang, Terence Hwa, and James R Williamson Published online 13.02.2015 A multi‐scale approach reveals that NF‐κB cRel enforces a B‐cell decision to divide A new multi‐scale model predicts B‐cell population dynamics in terms intra‐cellular molecular networks. We predict and confirm that NF‐κB cRel enforces cellular fate decisions and characterize how molecular network noise determines robust cell population dynamics. Maxim N Shokhirev, Jonathan Almaden, Jeremy Davis‐Turak, Harry A Birnbaum, Theresa M Russell, Jesse A D Vargas, and Alexander Hoffmann Published online 13.02.2015 Targeting a cell state common to triple‐negative breast cancers A chemical screen and systems approach reveal SYK‐STAT3 signaling as a druggable target in basal‐like breast cancers. The study supports the systems‐based notion that targeting a cell state, rather than a mutational state, can lead to therapeutic target discovery. Markus K Muellner, Barbara Mair, Yasir Ibrahim, Claudia Kerzendorfer, Hannelore Lechtermann, Claudia Trefzer, Freya Klepsch, André C Müller, Ernestine Leitner, Sabine Macho‐Maschler, Giulio Superti‐Furga, Keiryn L Bennett, José Baselga, Uwe Rix, Stefan Kubicek, Jacques Colinge, Violeta Serra, and Sebastian MB Nijman Published online 19.02.2015 Reviews Cell dynamics and gene expression control in tissue homeostasis and development Development and homeostasis require the regulation of cell fate assignment at the cell‐population level. Here we discuss how the control of stochastic events at the level of single cells is translated into coherent behavior in the population. Pau Rué and Alfonso Martinez Arias Published online 25.02.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.