Molecular Systems Biology - New articles published - 9 Mar 2015

March 2015 | Volume 11, Number 3 Submit Table of Contents Reports Articles Volume 11, Number 3 Reports Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia Drugs that reverse the omic signatures associated with dyslipidemia are shown to also restore physiological markers to their normal baselines. This provides a sound basis to computational methods that identify compounds which reverse a disease's omic signatures as potential therapeutic agents. Allon Wagner, Noa Cohen, Thomas Kelder, Uri Amit, Elad Liebman, David M Steinberg, Marijana Radonjic, and Eytan Ruppin Published online 03.03.2015 Articles Cell shape and the microenvironment regulate nuclear translocation of NF‐κB in breast epithelial and tumor cells High content image analysis of hundreds of thousands of single cells in combination with statistical modeling reveals relationships between cell shape and NF‐κB localization in normal and tumor breast epithelial cells. Julia E Sero, Heba Zuhair Sailem, Rico Chandra Ardy, Hannah Almuttaqi, Tongli Zhang, and Chris Bakal Published online 03.03.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.