Scientific Reports Biology Table of Contents e-alert: 27 January 2015

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27 January 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression ▶     Yasuo Yamauchi, Mikiko Kunishima, Masaharu Mizutani et al.     Abiotic stresses cause serious damage to plants; therefore, plants undergo a complicated stress response through signal transduction originating from environmental stimuli. Here …             DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells ▶     Seunghee Lee, Hyung-Sik Kim, Kyoung-Hwan Roh et al.     DNA methyltransferase (DNMT) inhibitors regulate target gene expression through epigenetic modifications, and these compounds have primarily been studied for cancer therapy or …             Transcriptomic analysis reveals the roles of microtubule-related genes and transcription factors in fruit length regulation in cucumber (Cucumis sativus L.) ▶     Li Jiang, Shuangshuang Yan, Wencai Yang et al.     Cucumber (Cucumis sativus L.) fruit is a type of fleshy fruit that is harvested immaturely. Early fruit development directly determines the final fruit length and diameter, and …             Developing genome-wide microsatellite markers of bamboo and their applications on molecular marker assisted taxonomy for accessions in the genus Phyllostachys ▶     Hansheng Zhao, Li Yang, Zhenhua Peng et al.     Morphology-based taxonomy via exiguously reproductive organ has severely limitation on bamboo taxonomy, mainly owing to infrequent and unpredictable flowering events of bamboo. …             Nonuniform gene expression pattern detected along the longitudinal axis in the matured rice leaf ▶     Ning Li, Yun-Ru Chen, Zehong Ding et al.     Rice (Oryza sativa) is a staple crop that supports half the world's population and an important monocot model system. Monocot leaf matures in a basipetal manner, and has a …             Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells ▶     Frank J. P. Kühn, Cornelia Kühn, Andreas Lückhoff     The human non-selective cation channel TRPM2 represents a mediator of apoptosis triggered by oxidative stress. The principal agonist ADP-ribose binds to the cytosolic domain of …             The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family ▶     Louise Kime, Helen A. Vincent, Deena M. A. Gendoo et al.     The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression. It is …             Aspiration dynamics in structured population acts as if in a well-mixed one ▶     Jinming Du, Bin Wu, Long Wang     Understanding the evolution of human interactive behaviors is important. Recent experimental results suggest that human cooperation in spatial structured population is not …             Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force ▶     Tao Guo, Liqiang Zhang, Anna Konermann et al.     Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as …             Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils ▶     Juliana D. B. Rocha, Michelle T. C. Nascimento, Debora Decote-Ricardo et al.     In the present study, we characterized the in vitro modulation of NETs (neutrophil extracellular traps) induced in human neutrophils by the opportunistic fungus Cryptococcus …             Effects of agricultural intensification on ability of natural enemies to control aphids ▶     Zi-Hua Zhao, Cang Hui, Da-Han He et al.     Agricultural intensification through increasing fertilization input and cropland expansion has caused rapid loss of semi-natural habitats and the subsequent loss of natural …             Embryonic stem cell differentiation requires full length Chd1 ▶     Paolo Piatti, Chin Yan Lim, Roxana Nat et al.     The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and …             Median Modified Wiener Filter for nonlinear adaptive spatial denoising of protein NMR multidimensional spectra ▶     Carlo Vittorio Cannistraci, Ahmed Abbas, Xin Gao     Denoising multidimensional NMR-spectra is a fundamental step in NMR protein structure determination. The state-of-the-art method uses wavelet-denoising, which may suffer when …             Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells ▶     Javier A. García-Vilas, Ana R. Quesada, Miguel A. Medina     Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the …             A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks ▶     Suyu Mei, Hao Zhu     Protein-protein interaction (PPI) prediction is generally treated as a problem of binary classification wherein negative data sampling is still an open problem to be addressed. …             Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway ▶     Joana Fraga, Ana Maranha, Vitor Mendes et al.     A novel four-step pathway identified recently in mycobacteria channels trehalose to glycogen synthesis and is also likely involved in the biosynthesis of two other crucial …             ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution ▶     Stephen R. Hennigar, Young Ah Seo, Supriya Sharma et al.     Mammary gland involution is the most dramatic example of physiological cell death. It occurs through an initial phase of lysosomal-mediated cell death (LCD) followed by …             Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer ▶     Bo Fu, Wei Long, Ying Zhang et al.     Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this …             Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning ▶     Lionel Blanchet, Jan A. M. Smeitink, Sjenet E. van Emst - de Vries et al.     In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and …             Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2 ▶     Sung Un Huh, Gil-Je Lee, Ji Hoon Jung et al.     Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional …             Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling ▶     Wang-Chuan Chen, Tien-Sheng Tseng, Nai-Wan Hsiao et al.     Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders that can be treated with depigmenting …             Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia ▶     Insaf Bahrini, Ji-hoon Song, Diego Diez et al.     Selective elimination of synaptic connections is a common phenomenon which occurs during both developmental and pathological conditions. Glial cells have a central role in the …             CORRIGENDUM: Resting-state functional reorganization of the rat limbic system following neuropathic injury ▶     M. N. Baliki, P. C. Chang, A. T. Baria et al.                 CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway ▶     Connor D. MacMillan, Hon S. Leong, David W. Dales et al.                 Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas ▶     Chunguang Luan, Lingling Xie, Xi Yang et al.     The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples …             Glycomic Signatures on Serum IgGs for Prediction of Postvaccination Response ▶     Jing-Rong Wang, Wen-Da Guan, Lee-Fong Yau et al.     Millions of individuals are vaccinated worldwide each year to stimulate their adaptive immune systems to produce protective antibodies and T-cell response against pathogens. …             Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity ▶     Wen-Jie Du, Jing-Jing Guo, Ming-Tao Gao et al.     Soluble amyloid β-protein (Aβ) oligomers, the main neurotoxic species, are predominantly formed from monomers through a fibril-catalyzed secondary nucleation. Herein, we …             Roles of 3,3′,4′,5-tetrachlorosalicylanilide in regulating extracellular electron transfer of Shewanella oneidensis MR-1 ▶     Yong-Peng Wang, Sheng-Song Yu, Hai-Ling Zhang et al.     Microbial extracellular electron transfer (EET) is critically involved in many pollutant conversion processes in both natural environment and engineered bioelectrochemical …             Deconvolution Analysis for Classifying Gastric Adenocarcinoma Patients Based on Differential Scanning Calorimetry Serum Thermograms ▶     Sonia Vega, María Asuncion Garcia-Gonzalez, Angel Lanas et al.     Recently, differential scanning calorimetry (DSC) has been acknowledged as a novel tool for diagnosing and monitoring several diseases. This highly sensitive technique has been …             The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis ▶     Zhuo Luan, Caitlin Quigley, Hong-Sheng Li     Most organisms are able to maintain systemic water homeostasis over a wide range of external or dietary osmolarities. The excretory system, composed of the kidneys in mammals and …             MBSTAR: multiple instance learning for predicting specific functional binding sites in microRNA targets ▶     Sanghamitra Bandyopadhyay, Dip Ghosh, Ramkrishna Mitra et al.     MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3′untranslated regions of its target genes. Machine learning based miRNA target prediction …             Analysis of the age of Panax ginseng based on telomere length and telomerase activity ▶     Jiabei Liang, Chao Jiang, Huasheng Peng et al.     Ginseng, which is the root of Panax ginseng (Araliaceae), has been used in Oriental medicine as a stimulant and dietary supplement for more than 7,000 years. Older ginseng plants …             Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation ▶     Rui-Feng Yang, Li-Hong Sun, Ran Zhang et al.     Precise regulation of mtDNA transcription and oxidative phosphorylation (OXPHOS) is crucial for human health. As a component of mitochondrial contact site and cristae organizing …             Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations ▶     Hong Qi, Linxi Li, Jianwei Shuai     A Ca2 signaling model is proposed to consider the crosstalk of Ca2 ions between endoplasmic reticulum (ER) and mitochondria within microdomains around inositol 1, 4, …             Complex forest dynamics indicate potential for slowing carbon accumulation in the southeastern United States ▶     John W. Coulston, David N. Wear, James M. Vose     Over the past century forest regrowth in Europe and North America expanded forest carbon (C) sinks and offset C emissions but future C accumulation is uncertain. Policy makers …             Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia ▶     Keiko Doi, Takahiko Imai, Christopher Kressler et al.     The Rap G protein signal regulates Notch activation in early thymic progenitor cells, and deregulated Rap activation (Raphigh) results in the development of Notch-dependent …             Evolutionary analysis of rubella viruses in mainland China during 2010–2012: endemic circulation of genotype 1E and introductions of genotype 2B ▶     Zhen Zhu, Pierre Rivailler, Emily Abernathy et al.     Rubella remains a significant burden in mainland China. In this report, 667 viruses collected in 24 of 31 provinces of mainland China during 2010–2012 were sequenced and …             Diminished serum repetin levels in patients with schizophrenia and bipolar disorder ▶     Shuai Wang, Huixun Ren, Jie Xu et al.     Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human …             Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries ▶     Ludovit Paulis, Jeremy Fauconnier, Olivier Cazorla et al.     Sonic hedgehog (SHH) is a conserved protein involved in embryonic tissue patterning and development. SHH signaling has been reported as a cardio-protective pathway via muscle …             N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential ▶     Krystal Teasley Hamorsky, J. Calvin Kouokam, Jessica M. Jurkiewicz et al.     Plant-based transient overexpression systems enable rapid and scalable production of subunit vaccines. Previously, we have shown that cholera toxin B subunit (CTB), an oral …             In Vitro Expansion of Corneal Endothelial Cells on Biomimetic Substrates ▶     Rachelle N. Palchesko, Kira L. Lathrop, James L. Funderburgh et al.     Corneal endothelial (CE) cells do not divide in vivo, leading to edema, corneal clouding and vision loss when the density drops below a critical level. The endothelium can be …             Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector ▶     Stina Bäckman, Jonas Näslund, Mats Forsman et al.     Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the …             Magnetic-activated cell sorting (MACS) can be used as a large-scale method for establishing zebrafish neuronal cell cultures ▶     Georg Welzel, Daniel Seitz, Stefan Schuster     Neuronal cell cultures offer a crucial tool to mechanistically analyse regeneration in the nervous system. Despite the increasing importance of zebrafish (Danio rerio) as an in …             AtNPF5.5, a nitrate transporter affecting nitrogen accumulation in Arabidopsis embryo ▶     Sophie Léran, Bharti Garg, Yann Boursiac et al.     Dipeptide (Leu-Leu) and nitrate transport activities of 26 Arabidopsis NPF (NRT1/PTR Family) proteins were screened in Saccharomyces cerevisiae and Xenopus laevis oocytes, …             Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol ▶     Hyeon Jeong Lee, Wandi Zhang, Delong Zhang et al.     We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Chol) and stimulated Raman scattering (SRS) microscope. The phenyl-diyne group …             A biliverdin-binding cyanobacteriochrome from the chlorophyll d–bearing cyanobacterium Acaryochloris marina ▶     Rei Narikawa, Takahiro Nakajima, Yuki Aono et al.     Cyanobacteriochromes (CBCRs) are linear tetrapyrrole-binding photoreceptors in cyanobacteria that absorb visible and near-ultraviolet light. CBCRs are divided into two types …             Engineering an in vitro air-blood barrier by 3D bioprinting ▶     Lenke Horváth, Yuki Umehara, Corinne Jud et al.     Intensive efforts in recent years to develop and commercialize in vitro alternatives in the field of risk assessment have yielded new promising two- and three dimensional (3D) …             The Hd, Hj, and Hz66 flagella variants of Salmonellaenterica serovar Typhi modify host responses and cellular interactions ▶     Fernanda Schreiber, Sally Kay, Gad Frankel et al.     Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacterium that exhibits limited phenotypic variation. S. Typhi from Indonesia are a …             PACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Developing Cerebellum ▶     Yue Yong, Ya Meng, Hanqing Ding et al.     PACT and its murine ortholog RAX were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase PKR. Recent studies indicated that …             Distinguishing Proteins From Arbitrary Amino Acid Sequences ▶     Stephen S.-T. Yau, Wei-Guang Mao, Max Benson et al.     What kinds of amino acid sequences could possibly be protein sequences? From all existing databases that we can find, known proteins are only a small fraction of all possible …             Cloud computing approaches for prediction of ligand binding poses and pathways ▶     Morgan Lawrenz, Diwakar Shukla, Vijay S. Pande     We describe an innovative protocol for ab initio prediction of ligand crystallographic binding poses and highly effective analysis of large datasets generated for protein-ligand …             3D-DIP-Chip: a microarray-based method to measure genomic DNA damage ▶     James Rees Powell, Mark Richard Bennett, Katie Ellen Evans et al.     Genotoxins cause DNA damage, which can result in genomic instability. The genetic changes induced have far-reaching consequences, often leading to diseases such as cancer. A wide …             An integrated phylogenomic approach toward pinpointing the origin of mitochondria ▶     Zhang Wang, Martin Wu     Overwhelming evidence supports the endosymbiosis theory that mitochondria originated once from the Alphaproteobacteria. However, its exact position in the tree of life remains …             Fossils reject climate change as the cause of extinction of Caribbean bats ▶     J. Angel Soto-Centeno, David W. Steadman     We combined novel radiocarbon dates of bat fossils with time-scaled ecological niche models (ENM) to study bat extinctions in the Caribbean. Radiocarbon-dated fossils show that …             Analysis of Genome-Wide RNA-Sequencing Data Suggests Age of the CEPH/Utah (CEU) Lymphoblastoid Cell Lines Systematically Biases Gene Expression Profiles ▶     Yuan Yuan, Lei Tian, Dongsheng Lu et al.     In human, Lymphoblastoid cell lines (LCLs) from the CEPH/CE (Centre d'Etude du Polymorphisme Humain – Utah) family resource have been extensively used for examining the genetics …             Genomic organization of the crested ibis MHC provides new insight into ancestral avian MHC structure ▶     Li-Cheng Chen, Hong Lan, Li Sun et al.     The major histocompatibility complex (MHC) plays an important role in immune response. Avian MHCs are not well characterized, only reporting highly compact Galliformes MHCs and …             Potent effects of dioscin against obesity in mice ▶     Min Liu, Lina Xu, Lianhong Yin et al.     The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its …             Intraoperative vascular DIVA surgery reveals angiogenic hotspots in tumor zones of malignant gliomas ▶     Ilker Y. Eyüpoglu, Nirjhar Hore, Zheng Fan et al.     Malignant gliomas belong to the most threatening tumor entities and are hallmarked by rapid proliferation, hypervascularization and an invasive growth pattern. The primary …             Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility ▶     Mingzhi Liao, Guangyu Wang, Baoku Quan et al.     Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been …             CO2 enrichment and N addition increase nutrient loss from decomposing leaf litter in subtropical model forest ecosystems ▶     Juxiu Liu, Xiong Fang, Qi Deng et al.     As atmospheric CO2 concentration increases, many experiments have been carried out to study effects of CO2 enrichment on litter decomposition and nutrient release. However, the …             Phosphate addition enhanced soil inorganic nutrients to a large extent in three tropical forests ▶     Feifei Zhu, Xiankai Lu, Lei Liu et al.     Elevated nitrogen (N) deposition may constrain soil phosphorus (P) and base cation availability in tropical forests, for which limited evidence have yet been available. In this …             Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke ▶     Efrat Shavit Stein, Zeev Itsekson-Hayosh, Anna Aronovich et al.     Acute brain ischemia modifies synaptic plasticity by inducing ischemic long-term potentiation (iLTP) of synaptic transmission through the activation of N-Methyl-D-aspartate …             The PUFA-Enriched Fatty Acid Profiles of some Frozen Bison from the Early Holocene found in the Siberian Permafrost ▶     José L. Guil-Guerrero, Ignacio Rodríguez-García, Irina Kirillova et al.     Knowledge concerning the availability of n-3 fatty acids for humans in prehistoric times is highly relevant in order to draw useful conclusions on the healthy dietary habits for …             Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin ▶     Rita Slaaby     This novel method enables specific measurement of the activation of hybrid receptors formed between the Insulin Receptor (IR) and the Insulin-like Growth Factor 1 Receptor …             Group size effect on cooperation in one-shot social dilemmas ▶     Hélène Barcelo, Valerio Capraro     Social dilemmas are central to human society. Depletion of natural resources, climate protection, security of energy supply, and workplace collaborations are all examples of …             GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing ▶     Huashan Zhao, Jingqiao Qiao, Shoubing Zhang et al.     G protein-coupled receptors (GPCRs) mediate multiple key biological processes in the body. The orphan receptor GPR39 has been reported to be involved in various …             Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2 ▶     Kazuhiro Suzuki, Kosuke Sako, Kazuhiro Akiyama et al.     The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P). At least in …             Angiogenin Secretion From Hepatoma Cells Activates Hepatic Stellate Cells To Amplify A Self-Sustained Cycle Promoting Liver Cancer ▶     Cristina Bárcena, Milica Stefanovic, Anna Tutusaus et al.     Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix …             Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying ▶     Susana Camacho, Stephanie Michlig, Carole de Senarclens-Bezençon et al.     Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon …             Comparative computational analysis of pluripotency in human and mouse stem cells ▶     Mathias Ernst, Raed Abu Dawud, Andreas Kurtz et al.     Pluripotent cells can be subdivided into two distinct states, the naïve and the primed state, the latter being further advanced on the path of differentiation. There are …             Image artifacts in Single Molecule Localization Microscopy: why optimization of sample preparation protocols matters ▶     Donna R. Whelan, Toby D. M. Bell     Single molecule localization microscopy (SMLM) techniques allow for sub-diffraction imaging with spatial resolutions better than 10 nm reported. Much has been discussed relating …             Identification of novel viral receptors with cell line expressing viral receptor-binding protein ▶     Mei Mei, Jianqiang Ye, Aijian Qin et al.     The viral cell receptors and infection can be blocked by the expression of the viral receptor-binding protein. Thus, the viral cell receptor is an attractive target for …             A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery ▶     Shayan F. Lahiji, Manita Dangol, Hyungil Jung     Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto …             Transcriptome and Histopathological Changes in Mouse Brain Infected with Neospora caninum ▶     Maki Nishimura, Sachi Tanaka, Fumiaki Ihara et al.     Neospora caninum is a protozoan parasite that causes neurological disorders in dogs and cattle. It can cause nonsuppurative meningoencephalitis and a variety of neuronal symptoms …             Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM ▶     Nidhan K. Biswas, Vikas Chandra, Neeta Sarkar-Roy et al.     Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM …             Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor ▶     Hei-Man Vincent Tang, Kewu Pan, Ka-Yiu Edwin Kong et al.     Ferredoxins are iron-sulfur proteins that play important roles in electron transport and redox homeostasis. Yeast Apd1p is a novel member of the family of thioredoxin-like …             Rice stripe virus affects the viability of its vector offspring by changing developmental gene expression in embryos ▶     Shuo Li, Shijuan Wang, Xi Wang et al.     Plant viruses may affect the viability and development process of their herbivore vectors. Small brown planthopper (SBPH) is main vector of Rice stripe virus (RSV), which causes …             Photoprotection in sequestered plastids of sea slugs and respective algal sources ▶     Sónia Cruz, Paulo Cartaxana, Rebecca Newcomer et al.     Some sea slugs are capable of retaining functional sequestered chloroplasts (kleptoplasts) for variable periods of time. The mechanisms supporting the maintenance of these …             Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan ▶     Dominik Bernhardt, Matthias Müller, Andreas S. Reichert et al.     Aging of biological systems is accompanied by degeneration of mitochondrial functions. Different pathways are active to counteract the processes which lead to mitochondrial …             siRNA induces gelsolin gene transcription activation in human esophageal cancer cell ▶     Guo-Wei Huang, Lian-Di Liao, En-Min Li et al.     Recent studies show that targeting gene promoter or 3′ terminal regions of mRNA with siRNA induces target gene transcription. However, the ability of exon-targeting siRNA to …             Checkpoint-dependent RNR induction promotes fork restart after replicative stress ▶     Esther C. Morafraile, John F. X. Diffley, José Antonio Tercero et al.     The checkpoint kinase Rad53 is crucial to regulate DNA replication in the presence of replicative stress. Under conditions that interfere with the progression of replication …             Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP) ▶     Jigang Wang, Chong-Jing Zhang, Jianbin Zhang et al.     Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. …             Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics ▶     Lurong Pan, Stephen G. Aller     P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that alternates between inward- and outward-facing conformations to capture and force substrates out of cells …             Large number of putative chemoreception and pheromone biosynthesis genes revealed by analyzing transcriptome from ovipositor-pheromone glands of Chilo suppressalis ▶     Yi-Han Xia, Ya-Nan Zhang, Xiao-Qing Hou et al.     The chemoreception role of moth ovipositor has long been suggested, but its molecular mechanism is mostly unknown. By transcriptomic analysis of the female ovipositor-pheromone …             Characterising two-pathogen competition in spatially structured environments ▶     Chiara Poletto, Sandro Meloni, Ashleigh Van Metre et al.     Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the …             A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke ▶     Cheng-long Xie, Wen-Wen Wang, Xiao-Dong Xue et al.     The neuroprotective actions of Ginsenoside-Rg1 (G-Rg1) have been documented for experimental stroke therapy. We used a systematic review and meta-analysis to assess the efficacy …             Functional Loop Dynamics of the Streptavidin-Biotin Complex ▶     Jianing Song, Yongle Li, Changge Ji et al.     Accelerated molecular dynamics (aMD) simulation is employed to study the functional dynamics of the flexible loop3-4 in the strong-binding streptavidin-biotin complex system. …             Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage ▶     Sheng Tao Hou, Ladan Nilchi, Xuesheng Li et al.     Semaphorin 3A (Sema3A) increased significantly in mouse brain following cerebral ischemia. However, the role of Sema3A in stroke brain remains unknown. Our aim was to determine …             Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma ▶     Jian Guan, Rohit Gupta, Fabian V. Filipp     We characterized the mutational landscape of human skin cutaneous melanoma (SKCM) using data obtained from The Cancer Genome Atlas (TCGA) project. 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