Nature Cell Biology contents: December 2014 Volume 16 Number 12, pp 1127 - 1264

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Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization. See also: Article by Viotti et al. Rsp5/Nedd4 clears cells of heat-damaged proteins   pp1130 - 1132 Thomas Sommer, Annika Weber and Ernst Jarosch doi:10.1038/ncb3079 Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat. See also: Article by Guo et al. Sugar modification inhibits autophagosome-lysosome fusion   pp1132 - 1133 Noboru Mizushima doi:10.1038/ncb3078 Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals. See also: Article by Fang et al. Cell Biology JOBS of the week Head- Department of Anatomy and Cell Biology University of Illinois Research Associate - Cell & Developmental Biology University of Massachusetts POST-DOCTORAL POSITION - Stem Cell and RNA Biology Lund University Stem Cell Biology Researcher Northwestern University More Science jobs from Cell Biology EVENT 2015 Conference on Advances in Cell Biology (CACB 2015) 20.03.15 Virgina, USA More science events from Advertisement Start Imaging Fluorescence Without a Darkroom The ZOE™ Fluorescent Cell Imager is a complete digital imaging system that uses an intuitive touch-screen user interface to control brightfield, three fluorescence imaging channels, and an integrated digital camera. Users can capture and store images and create multicolor merges with minimal training and a light shield allows fluorescence imaging in ambient light.   Articles Top Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate   pp1135 - 1145 Agnes Lim, Kunyoo Shin, Chen Zhao, Sally Kawano and Philip A. Beachy doi:10.1038/ncb3057 Beachy and colleagues demonstrate that reduced Hedgehog (Hh) signalling at the tips of nascent buds allows stromal production of hepatocyte growth factor (Hgf), whereas in surrounding cells Hh inhibits Hgf through induction of miR-26a and miR-26b. SOX17 links gut endoderm morphogenesis and germ layer segregation   pp1146 - 1156 Manuel Viotti, Sonja Nowotschin and Anna-Katerina Hadjantonakis doi:10.1038/ncb3070 Using time-lapse imaging Hadjantonakis and colleagues have characterized the intercalation of definitive endoderm progenitors into the overlying visceral endoderm during mouse gastrulation and demonstrated a role for the transcription factor SOX17 in this process. See also: News and Views by McDonald & Rossant A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones   pp1157 - 1167 Noriaki Ono, Wanida Ono, Takashi Nagasawa and Henry M. Kronenberg doi:10.1038/ncb3067 Kronenberg and colleagues report that mesenchymal progenitor cells in endochondral bones express chondrocyte markers. By lineage tracing, they see that this population contributes to chondrocytes, osteoblasts and stromal cells in postnatal bones. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage   pp1168 - 1179 Michael M. Mueller, Laia Castells-Roca, Vipin Babu, Maria A. Ermolaeva, Roman-Ulrich Müller et al. doi:10.1038/ncb3071 Schumacher and colleagues find that the FOXO transcription factor DAF-16 is activated in response to DNA damage in C. elegans and promotes developmental growth in a manner involving EGL-27. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice   pp1180 - 1191 Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y. Tyurina, Vladimir A. Tyurin et al. doi:10.1038/ncb3064 Ferroptosis is a form of non-apoptotic cell death with unclear physiological relevance. Conrad and colleagues now report that unrestrained ferroptosis can lead to renal failure. They also identify a small molecule that limits ferroptosis in vivo. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport   pp1192 - 1201 Suvranta K. Tripathy, Sarah J. Weil, Chen Chen, Preetha Anand, Richard B. Vallee et al. doi:10.1038/ncb3063 Through biochemical and single-molecule analyses, Vallee, Gross and colleagues characterize how subdomains of the dynactin subunit p150 regulate dynein movement along microtubules. Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs   pp1202 - 1214 Christopher John Bowman, Donald E. Ayer and Brian David Dynlacht doi:10.1038/ncb3062 Dynlacht and colleagues report that Foxk transcription factors inhibit the induction of autophagy by recruiting Sin3A–HDAC complexes to autophagy-promoting genes to limit their expression. O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation   pp1215 - 1226 Bin Guo, Qianqian Liang, Lin Li, Zhe Hu, Fan Wu et al. doi:10.1038/ncb3066 Zhang and colleagues report that starvation reduces O-GlcNAcylation of the SNARE protein SNAP-29. This promotes formation of a competent SNARE complex that increases autophagosome–lysosome fusion, increasing autophagosome maturation and flux. See also: News and Views by Sommer et al. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress   pp1227 - 1237 Nancy N. Fang, Gerard T. Chan, Mang Zhu, Sophie A. Comyn, Avinash Persaud et al. doi:10.1038/ncb3054 Mayor and colleagues identify yeast Rsp5 (mammalian homologue Nedd4) as the main ubiquitin ligase responsible for the increased ubiquitylation following heat stress when Rsp5 targets cytosolic misfolded proteins for proteasome degradation. See also: News and Views by Mizushima A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis   pp1238 - 1248 Ferenc A. Scheeren, Angera H. Kuo, Linda J. van Weele, Shang Cai, Iris Glykofridis et al. doi:10.1038/ncb3058 Clarke and colleagues show that TLR2–MYD88 cancer-cell-intrinsic signalling is involved in mammary and colon epithelial regeneration and tumour formation. Letters Top Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces   pp1249 - 1256 Marin Barisic, Paulo Aguiar, Stephan Geley and Helder Maiato doi:10.1038/ncb3060 By live imaging and laser microsurgery, Maiato and colleagues characterize how the chromokinesin, dynein and CENP-E motor proteins cooperate to congress chromosomes peripheral to the spindle poles of the metaphase plate in mitosis. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal   pp1257 - 1264 Wilco Nijenhuis, Giulia Vallardi, Antoinette Teixeira, Geert J. P. L. Kops and Adrian T. Saurin doi:10.1038/ncb3065 Saurin, Kops and colleagues suggest that rapid spindle assembly checkpoint (SAC) responsiveness is mediated by a mechanism in which active SAC recruits PP2A, leading to PP1 recruitment, which in turn displaces PP2A and shuts off the SAC. Top Advertisement Nature Reviews Microbiology FREE POSTER CRISPR-Cas: extraordinary editing This Poster presents the molecular mechanism of CRISPR-Cas interference and highlights the use of specifically engineered guide RNAs and the Cas9 nuclease for the editing of virtually any desired genome, in addition to other applications such as imaging in live cells and the regulation of gene expression. 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