The EMBO Journal Table of Contents for 3 November 2014; Vol. 33, No. 21

3 November 2014 | Volume 33, Number 21 Submit Table of Contents Have you seen? Articles Volume 33, Number 21 Have you seen? The RAS and YAP1 dance, who is leading? Recent studies revealed an intimate crosstalk between Hippo/YAP1 and oncogenic RAS signaling in tumors. Complementary data published in The EMBO Journal establish RAS to antagonize Hippo function by regulating YAP protein stability. Vincenzo Corbo, Mariano Ponz‐Sarvise, and David A Tuveson Published online 25.09.2014 Membrane tension drives ligand‐independent integrin signaling A novel mechanism of interaction adhesion receptors is discussed in which integrins are activated by membrane tension generated by uPAR in the absence of integrin‐ligand binding. Ralph Thomas Böttcher and Reinhard Fässler Published online 17.09.2014 DUBs counteract parkin for efficient mitophagy The Parkinson's disease‐associated ubiquitin ligase parkin is regulated by the deubiquitinases USP8, USP15 and USP30 — either directly through de‐ubiquitination of parkin or by removing ubiquitin from mitochondrial proteins, ensuring regulation of the ubiquitin signals that trigger mitophagy. Ivan Dikic and Anja Bremm Published online 01.10.2014 RESETing ER proteostasis: selective stress pathway hidden in the secretory route A secretory pathway maintains ER proteostasis by targeting misfolded GPI‐anchored proteins to the plasma membrane for subsequent endocytic uptake and lysosomal degradation. Andrés Couve and Claudio Hetz Published online 04.09.2014 Articles Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover Ras antagonises Hippo tumor suppressor activity by direct regulation of YAP‐stability. Ras controls SOCS‐protein expression, channeling YAP into ubiquitin‐dependent degradation. Xin Hong, Hung Thanh Nguyen, Qingfeng Chen, Rui Zhang, Zandra Hagman, P Mathijs Voorhoeve, and Stephen M Cohen Published online 01.09.2014 The interaction between uPAR and vitronectin triggers ligand‐independent adhesion signalling by integrins Cell adhesion mediated by uPAR and other adhesion receptors triggers non‐canonical integrin activation independent of integrin–ligand interactions. The cross‐talk between adhesion receptors and integrins is mediated by membrane tension. Gian Maria Sarra Ferraris, Carsten Schulte, Valentina Buttiglione, Valentina De Lorenzi, Andrea Piontini, Massimiliano Galluzzi, Alessandro Podestà, Chris D Madsen, and Nicolai Sidenius Published online 28.08.2014 USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin The deubiquitinase USP8 is required for parkin recruitment to mitochondria and thus mitophagy by removing K6‐linked ubiquitin conjugates from parkin hence opposing its auto‐ubiquitination. Thomas M Durcan, Matthew Y Tang, Joëlle R Pérusse, Eman A Dashti, Miguel A Aguileta, Gian‐Luca McLelland, Priti Gros, Thomas A Shaler, Denis Faubert, Benoit Coulombe, and Edward A Fon Published online 12.09.2014 Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u SPP, an intramembrane protease involved in ER signal peptide cleavage, functions in a novel ERAD branch to catalyze proteolysis of the unfolded protein response (UPR) regulator XPB1u in complex with Derlin1 and TRC8. Chia‐yi Chen, Nicole S Malchus, Beate Hehn, Walter Stelzer, Dönem Avci, Dieter Langosch, and Marius K Lemberg Published online 19.09.2014 Determinants of G quadruplex‐induced epigenetic instability in REV1‐deficient cells Maintenance of ‘active’ histone modification patterns and gene expression at an endogenous reporter gene locus requires its processive replication, being affected by G4 DNA formation on the leading strand template close to the transcription start site. Davide Schiavone, Guillaume Guilbaud, Pierre Murat, Charikleia Papadopoulou, Peter Sarkies, Marie‐Noëlle Prioleau, Shankar Balasubramanian, and Julian E Sale Published online 04.09.2014 FANCJ promotes DNA synthesis through G‐quadruplex structures A cell‐free model system recapitulating replication of G4 DNA shows that G4 motifs form a transient replication barrier, which is unwound and overcome through the help of the FANCJ/BRIP1 helicase. Pau Castillo Bosch, Sandra Segura‐Bayona, Wouter Koole, Jane T van Heteren, James M Dewar, Marcel Tijsterman, and Puck Knipscheer Published online 05.09.2014 Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex The molecular interactions between SAGA subunits and its modules are determined using a combination of crosslinking and mass spectrometry together with genetic and biochemical analysis. Yan Han, Jie Luo, Jeffrey Ranish, and Steven Hahn Published online 12.09.2014 A monovalent cation acts as structural and catalytic cofactor in translational GTPases X‐ray structures of eIF5B and aEF1A reveal the presence of a monovalent cation in the active site, thus offering insight on the mechanism of GTP hydrolysis and prompting the re‐interpretation of earlier studies on translational GTPases. Bernhard Kuhle and Ralf Ficner Published online 15.09.2014 The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density The chemokine CCL2 and its scavenging receptor ACKR2 antagonistically regulate lymphatic vessel density. This is the result of the developmental control of the proximity of pro‐lymphangiogenic macrophages to lymphatic vessels. Kit M Lee, Renzo Danuser, Jens V Stein, Delyth Graham, Robert JB Nibbs, and Gerard J Graham Published online 30.09.2014 The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines A RING domain‐like fold within the mouse MEK Kinase 1 polyubiquitylates TAK1‐binding protein 1 (TAB1), a critical adaptor in the TGF‐β signaling pathway, which stimulates Mitogen‐Activated Protein Kinase signaling and is required for correct embryonic stem cell differentiation and tumourigenicity, and for cardiac, testis and B‐cell development in mice in vivo. Nikolaos Charlaftis, Tesha Suddason, Xuefeng Wu, Saba Anwar, Michael Karin, and Ewen Gallagher Published online 26.09.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.