Scientific Reports Biology Table of Contents e-alert: 4 November 2014

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04 November 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Nature Genetics, the Chinese Academy of Agricultural Sciences, and the Chinese Academy of Sciences present: Agricultural Genomics - From Variation to Crops November 10-12, 2014 Soluxe International Convention Center, Beijing, China  Click here for more information or to register for this conference today!             Biological Sciences               Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear ▶     Brandon C. Cox, Jennifer A. Dearman, Joseph Brancheck et al.     Atoh1 is a basic helix-loop-helix transcription factor that controls differentiation of hair cells (HCs) in the inner ear and its enhancer region has been used to create several …             Prolonged withdrawal following cocaine self-administration increases resistance to punishment in a cocaine binge ▶     Amy M. Gancarz-Kausch, Danielle N. Adank, David M. Dietz     Drug addiction is characterized by compulsive drug-taking behaviors and a high propensity to relapse following drug cessation. Drug craving and seeking can increase during a …             Population Structure and Spatial Pattern of Main Tree Species in Secondary Betula platyphylla Forest in Ziwuling Mountains, China ▶     Di Kang, Yaoxin Guo, Chengjie Ren et al.     This study investigated a typical secondary Betula platyphylla forest in the Ziwuling Mountains, Loess Plateau, China. In the sample plot, the DBH (diameter at breast height) …             Revealing Origin of Decrease in Potency of Darunavir and Amprenavir against HIV-2 relative to HIV-1 Protease by Molecular Dynamics Simulations ▶     Jianzhong Chen, Zhiqiang Liang, Wei Wang et al.     Clinical inhibitors Darunavir (DRV) and Amprenavir (APV) are less effective on HIV-2 protease (PR2) than on HIV-1 protease (PR1). To identify molecular basis associated with the …             Molecular cloning and analysis of gonadal expression of Foxl2 in the rice-field eel Monopterus albus ▶     Qing Hu, Wei Guo, Yu Gao et al.     We isolated the complete Foxl2 (Foxl2a) cDNA from the Monopterus albus ovary. An alignment of known Foxl2 amino-acid sequences confirmed the conservation of the Foxl2 open …             Microstructural Abnormalities in the Combined and Inattentive Subtypes of Attention Deficit Hyperactivity Disorder: a Diffusion Tensor Imaging Study ▶     Du Lei, Jun Ma, Xiaoxia Du et al.     Previous research has demonstrated that there are specific white matter abnormalities in patients with attention deficit/hyperactivity disorder (ADHD). However, the results of …             Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA ▶     Hong Yeol Yoon, Sejin Son, So Jin Lee et al.     Conventional chemotherapy is plagued with adverse side effects because cancer treatments are subject to numerous variations, most predominantly from drug resistance. Accordingly, …             Genome editing of BmFib-H gene provides an empty Bombyx mori silk gland for a highly efficient bioreactor ▶     Sanyuan Ma, Run Shi, Xiaogang Wang et al.     Evolution has produced some remarkable creatures, of which silk gland is a fascinating organ that exists in a variety of insects and almost half of the 34,000 spider species. The …             Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma ▶     Tiehong Zhang, Hongchang Shen, Wei Dong et al.     The insulin-like growth factor type 1 receptor (IGF-1R) plays an essential role in the development of numerous cancers. Figitumumab (CP) is not only a monocloncal antibody, it …             A novel perspective on seed yield of broad bean (Vicia faba L.): differences resulting from pod characteristics ▶     Xiong Li, Yongping Yang     Broad bean (Vicia faba L.) is an important crop worldwide. An increase in seed yield would increase both the grain reserve and the profit for farmers. Previous studies on …             Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices ▶     Maurizio Pezzoli, Abdeladim Elhamdani, Susana Camacho et al.     Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores …             Bicaudal-C is required for the formation of anterior neurogenic ectoderm in the sea urchin embryo ▶     Shunsuke Yaguchi, Junko Yaguchi, Kazuo Inaba     bicaudal-C (bicC) mRNA encodes a protein containing RNA-binding domains that is reported to be maternally present with deflection in the oocytes/eggs of some species. The …             Synthesis and Antibacterial Activities of Antibacterial Peptides with a Spiropyran Fluorescence Probe ▶     Lei Chen, Yu Zhu, Danling Yang et al.     In this report, antibacterial peptides1-3 were prepared with a spiropyran fluorescence probe. The probe exhibits a change in fluorescence when isomerized from a colorless …             Two novel DNA motifs are essential for BACE1 gene transcription ▶     Yan Xiang, Shasha Meng, Jinfeng Wang et al.     BACE1 gene encodes for β-Site amyloid β precursor protein (APP)-cleaving enzyme1, which is required for generating amyloid β protein(Aβ). Deposition of Aβ in brain plays an …             A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells ▶     Swapnil V. Bhujbal, Bart de Haan, Simone P. Niclou et al.     Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most …             Calmodulin-like protein from M. tuberculosis H37Rv is required during infection ▶     Meeta J. Advani, Malini Rajagopalan, P. Hemalatha Reddy     M. tuberculosis constitutes very sophisticated signaling systems that convert the environment signals into appropriate cellular response and helps the bacilli to overcome the …             Radiocesium contamination of greenlings (Hexagrammos otakii) off the coast of Fukushima ▶     Yuya Shigenobu, Ken Fujimoto, Daisuke Ambe et al.     We measured the radiocesium (134Cs and 137Cs) contamination of 236 greenlings (Hexagrammos otakii) off the coast of Fukushima Prefecture in Japan, following the accident at the …             Elevated levels of serum sICAM-1 in asphyxiated low birth weight newborns ▶     Saadat Huseynova, Nushaba Panakhova, Pusta Orujova et al.     Perinatal hypoxia results in neuronal and endothelial cell damage. The main purpose of this study was to investigate the correlation of soluble intercellular adhesion molecule 1 …             Correlative Electron and Fluorescence Microscopy of Magnetotactic Bacteria in Liquid: Toward In Vivo Imaging ▶     Taylor J. Woehl, Sanjay Kashyap, Emre Firlar et al.     Magnetotactic bacteria biomineralize ordered chains of uniform, membrane-bound magnetite or greigite nanocrystals that exhibit nearly perfect crystal structures and …             A graphene-based physiometer array for the analysis of single biological cells ▶     Geraldine L. C. Paulus, Justin T. Nelson, Katherine Y. Lee et al.     A significant advantage of a graphene biosensor is that it inherently represents a continuum of independent and aligned sensor-units. We demonstrate a nanoscale version of a …             Identification of a mammalian vesicular polyamine transporter ▶     Miki Hiasa, Takaaki Miyaji, Yuka Haruna et al.     Spermine and spermidine act as neuromodulators upon binding to the extracellular site(s) of various ionotropic receptors, such as N-methyl-d-aspartate receptors. To gain access …             The early diagnosis and monitoring of squamous cell carcinoma via saliva metabolomics ▶     Qihui Wang, Pan Gao, Xiaoyi Wang et al.     Early diagnosis of oral squamous cell carcinoma (OSCC) is an attractive strategy to increase survival rate of patient. An integrated separation approach of reversed phase liquid …             Loss of α-catenin elicits a cholestatic response and impairs liver regeneration ▶     Keira Joann Herr, Ying-hung Nicole Tsang, Joanne Wei En Ong et al.     The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, …             Massive fungal biodiversity data re-annotation with multi-level clustering ▶     Duong Vu, Szániszló Szöke, Christian Wiwie et al.     With the availability of newer and cheaper sequencing methods, genomic data are being generated at an increasingly fast pace. In spite of the high degree of complexity of …             The Tribolium castaneum cell line TcA: a new tool kit for cell biology ▶     Kristopher Silver, Hongbo Jiang, Jinping Fu et al.     The red flour beetle, Tribolium castaneum, is an agriculturally important insect pest that has been widely used as a model organism. Recently, an adherent cell line …             Virus detection and quantification using electrical parameters ▶     Mahmoud Al Ahmad, Farah Mustafa, Lizna M. Ali et al.     Here we identify and quantitate two similar viruses, human and feline immunodeficiency viruses (HIV and FIV), suspended in a liquid medium without labeling, using a semiconductor …             HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform ▶     Farhana Nasrin, Mohammad Alinoor Rahman, Akio Masuda et al.     Muscle specific receptor tyrosine kinase (MuSK) is an essential postsynaptic transmembrane molecule that mediates clustering of acetylcholine receptors (AChR). MUSK exon 10 is …             Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applied to virus identification ▶     Adriana Calderaro, Maria-Cristina Arcangeletti, Isabella Rodighiero et al.     Virus detection and/or identification traditionally rely on methods based on cell culture, electron microscopy and antigen or nucleic acid detection. These techniques are good, …             Attenuation of veterinary antibiotics in full-scale vermicomposting of swine manure via the housefly larvae (Musca domestica) ▶     ZhiJian Zhang, JianGuo Shen, Hang Wang et al.     Animal waste from concentrated swine farms is widely considered to be a source of environmental pollution, and the introduction of veterinary antibiotics in animal manure to …             NRfamPred: A proteome-scale two level method for prediction of nuclear receptor proteins and their sub-families ▶     Ravindra Kumar, Bandana Kumari, Abhishikha Srivastava et al.     Nuclear receptor proteins (NRP) are transcription factor that regulate many vital cellular processes in animal cells. NRPs form a super-family of phylogenetically related …             Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release ▶     Laura Facci, Massimo Barbierato, Carla Marinelli et al.     Interleukin-1β (IL-1β) is a crucial mediator in the pathogenesis of inflammatory diseases at the periphery and in the central nervous system (CNS). Produced as an unprocessed and …             Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model ▶     Rani Kunjithapatham, Swathi Karthikeyan, Jean-Francois Geschwind et al.     Lack of an in vitro model of metastasis has been a major impediment in understanding the molecular regulation of metastatic processes, and identification of specific therapeutic …             Direct Visualization of De novo Lipogenesis in Single Living Cells ▶     Junjie Li, Ji-Xin Cheng     Increased de novo lipogenesis is being increasingly recognized as a hallmark of cancer. Despite recent advances in fluorescence microscopy, autoradiography and mass spectrometry, …             Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats ▶     SuFang Zhang, ChengLong Xie, Qiang Wang et al.     Ca2/calmodulin-dependent protein kinase II is a synapse-enriched kinase in mammalian brains. This kinase interacts with various synaptic proteins to regulate expression and …             A Comparative Study of Fast-Track Verus Conventional Surgery in Patients Undergoing Laparoscopic Radical Cystectomy and Ileal Conduit Diversion: Chinese Experience ▶     Xiao Guan, Longfei Liu, Xiang Lei et al.     Fast-track surgery (FTS), which combines various techniques with evidence-based adjustments, is aimed to reduce postoperative morbidity, attenuate surgical stress response, …             CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest ▶     Wen Pan, Yingying Cheng, Heyu Zhang et al.     Cytokines are soluble proteins that exert their functions by binding specific receptors. Many cytokines play essential roles in carcinogenesis and have been developed for the …             Noninvasive Molecular Imaging of Cell Death in Myocardial Infarction using 111In-GSAO ▶     Nobuhiro Tahara, H. Reinier Zandbergen, Hans J. de Haas et al.     Acute insult to the myocardium is associated with substantial loss of cardiomyocytes during the process of myocardial infarction. In this setting, apoptosis (programmed cell …             Opposite metabolic responses of shoots and roots to drought ▶     Albert Gargallo-Garriga, Jordi Sardans, Míriam Pérez-Trujillo et al.     Shoots and roots are autotrophic and heterotrophic organs of plants with different physiological functions. Do they have different metabolomes? Do their metabolisms respond …             Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy ▶     Fei Wang, Pei Liu, Lin Sun et al.     Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting …             Motor preparation attenuates neural variability and beta-band LFP in parietal cortex ▶     Mo Chen, Linyu Wei, Yu Liu     Accumulative evidence shows that neural variability is meaningful and powerful during brain information processing, but how cognitive state influences neural variability is still …             Heuristics guide the implementation of social preferences in one-shot Prisoner's Dilemma experiments ▶     Valerio Capraro, Jillian J. Jordan, David G. Rand     Cooperation in one-shot anonymous interactions is a widely documented aspect of human behaviour. Here we shed light on the motivations behind this behaviour by experimentally …             Cellular manganese content is developmentally regulated in human dopaminergic neurons ▶     Kevin K. Kumar, Edward W. Lowe, Jr., Asad A. Aboud et al.     Manganese (Mn) is both an essential biological cofactor and neurotoxicant. Disruption of Mn biology in the basal ganglia has been implicated in the pathogenesis of …             Association of BRCA2 N372H polymorphism with cancer susceptibility: A comprehensive review and meta-analysis ▶     Wen-Qiong Xue, Yong-Qiao He, Jin-Hong Zhu et al.     BRCA2 gene plays an important role in homologous recombination. Polymorphic variants in this gene has been suggested to confer cancer susceptibility. Numerous studies have …             Impact of N-acetylcysteine and sesame oil on lipid metabolism and hypothalamic-pituitary-adrenal axis homeostasis in middle-aged hypercholesterolemic mice ▶     Laskarina-Maria Korou, George Agrogiannis, Christos Koros et al.     Hyperlipidemia and stress are important factors affecting cardiovascular health in middle-aged individuals. We investigated the effects of N-acetylcysteine (NAC) and sesame oil …             Functional Phylogenetics Reveals Contributions of Pleiotropic Peptide Action to Ligand-Receptor Coevolution ▶     Hongbo Jiang, Zhaojun Wei, Ronald J. Nachman et al.     The evolution of peptidergic signaling has been accompanied by a significant degree of ligand-receptor coevolution. Closely related clusters of peptide signaling molecules are …               MARKETPLACE: Great deals on the latest lab equipment New Lab Offers and Product Focus are in! 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