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Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The September 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with Harbour Antibodies BV.
Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The September 2014 issue of Biopharma Dealmakersshowcases companies with partnering opportunities. This week, find out about how you can collaborate with Immunovaccine Inc.
Boosting adjuvants Stephen Parmley doi:10.1038/scibx.2014.1281 The NIH is committing $70 million to creating new adjuvants that can work with different types of vaccines and wants industry to get involved. Full Text | PDF
Translational tidbits Kai-Jye Lou, Stephen Parmley and Mark Zipkin doi:10.1038/scibx.2014.1282 Merck KGaA enters the tankyrase race; Pluristem joins with Case Western to test its new cell therapy; Astellas' AIM unit targets Boston for innovation; the White House clamps down on gain-of-function studies; a round-up of public-private partnerships. Full Text | PDF
Building blood vessels Kai-Jye Lou doi:10.1038/scibx.2014.1283 Indiana University researchers have found a route to building blood vessels by developing a protocol to generate mass quantities of endothelium-forming cells. Full Text | PDF
SQZ Biotech's main squeeze Michael J. Haas doi:10.1038/scibx.2014.1284 Two awards totaling over $300,000 will fuel SQZ Biotech's scale-up of its microfluidics-based CellSqueeze platform that delivers bioactive materials directly into cells. Full Text | PDF
Bone morphogenetic protein 4 (BMP4); BMP5; smoothened (SMO) doi:10.1038/scibx.2014.1285 Mouse studies suggest activating BMP4 and BMP5 signaling could help treat bladder cancer. Full Text | PDF
PDZ binding kinase (PBK; TOPK) doi:10.1038/scibx.2014.1286 Mouse studies suggest a selective TOPK inhibitor could be used to treat breast and lung cancer. Full Text | PDF
Epidermal growth factor receptor 3 (EGFR3; HER3; ErbB3) doi:10.1038/scibx.2014.1287 In vitro studies identified a bivalent, ATP-competitive HER3 antagonist that could help treat HER3-dependent cancers. Full Text | PDF
Phosphoinositide 3-kinase (PI3K); PI3K class 3 (Vps34) doi:10.1038/scibx.2014.1288 In vitro studies have identified the small molecule SAR405 as a potent and selective Vps34 inhibitor that could help treat cancer. Full Text | PDF
Toll-like receptor 4 (TLR4); HPV antigens; survivin (BIRC5) doi:10.1038/scibx.2014.1289 Mouse studies suggest a combination of adjuvants could help improve the efficacy of cancer vaccines. Full Text | PDF
p53 doi:10.1038/scibx.2014.1290 Mouse studies suggest activating p53 in cardiac fibroblasts could help treat ischemia/reperfusion injury. Full Text | PDF
Ceramide synthase 6 (CERS6; LASS6) doi:10.1038/scibx.2014.1291 In vitro and mouse studies suggest inhibiting CERS6 could help treat obesity and diabetes. Full Text | PDF
Adenosine A2A receptor (ADORA2A) doi:10.1038/scibx.2014.1292 Mouse studies suggest ADORA2A agonists could activate brown adipose tissue (BAT) to help treat obesity. Full Text | PDF
Estrogen receptor-α; peroxisome proliferation–activated receptor-γ coactivator 1α (PPARGC1A; PGC-1α) doi:10.1038/scibx.2014.1293 In vitro and mouse studies suggest increasing hypothalamic PGC-1α expression could help protect against obesity and metabolic disorders. Full Text | PDF
Ixodes scapularis antifreeze glycoprotein (iafgp); poly-N-acetyl glucosamine (PNAG) doi:10.1038/scibx.2014.1294 Rodent, fruit fly and cell culture studies suggest iafgp derived from the I. scapularis tick could help prevent and treat bacterial infections by disrupting biofilm formation. Full Text | PDF
Cyclophilin doi:10.1038/scibx.2014.1295 Cell culture studies suggest nonimmunosuppressive cyclosporine-based cyclophilin inhibitors could help treat HCV infections with decreased toxicity risk. Full Text | PDF
Sphingosine 1-phosphate receptor 3 (S1PR3; S1P3; EDG3); calcitonin receptor doi:10.1038/scibx.2014.1296 Mouse studies suggest antagonizing the calcitonin receptor or agonizing S1PR3 could help treat osteoporosis. Full Text | PDF
Sterol O-aceyltransferase 1 (SOAT1; ACAT1); β-amyloid (Aβ); Aβ42 doi:10.1038/scibx.2014.1297 Cell culture and mouse studies suggest inhibitors of ACAT1 could help treat AD by promoting microglia-mediated clearance of Aβ. Full Text | PDF
Borna disease virus p10 (BDV p10; BDV X; BDVgp1a) doi:10.1038/scibx.2014.1298 Mouse and cell culture studies suggest a peptide derived from BDV X could help treat PD. Full Text | PDF
Somatic mutation finder (SMUFIN) to identify single-nucleotide variants (SNVs) and structural variants in tumor DNA doi:10.1038/scibx.2014.1299 The SMUFIN computational approach could help identify different forms of somatic mutations in cancer. Full Text | PDF
Clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing for creating mice bearing oncogenic chromosomal arrangements doi:10.1038/scibx.2014.1300 CRISPR-Cas9 genome editing could be useful for creating mice bearing oncogenic chromosomal arrangements such as EML4-ALK oncogenic fusion protein. Full Text | PDF
Protein nanocapsules for tumor-targeted delivery of recombinant p53 protein doi:10.1038/scibx.2014.1301 Tumor-targeted protein nanocapsules could be useful for delivering anticancer proteins. Full Text | PDF
CD8 + T cells that express phosphopeptide-targeted T cell receptor (TCR) to treat cancer doi:10.1038/scibx.2014.1302 Mouse studies suggest CD8+ T cells expressing TCRs that engage with phosphopeptide antigens could help treat various cancers. Full Text | PDF
Cell therapy for Parkinson's disease (PD) using dopamine-like neurons differentiated from induced primitive neural stem cells doi:10.1038/scibx.2014.1303 Rat studies suggest dopamine-like neurons differentiated from neural stem cells could help treat PD. Full Text | PDF
Human pluripotent stem cell–derived intestinal organoids with in vivo functionality doi:10.1038/scibx.2014.1304 Mouse studies suggest human intestinal organoids (HIOs) could be used for intestinal regeneration and to study GI infections. Full Text | PDF
Microcapillary rheometer for obtaining viscosity measurements of therapeutic protein solutions doi:10.1038/scibx.2014.1305 A pressure-driven microcapillary rheometer could measure viscosity using small sample volumes, which could help determine the amenability of therapeutic proteins to syringe-mediated delivery. Full Text | PDF
Long noncoding RNA (lncRNA) markers for prostate cancer doi:10.1038/scibx.2014.1306 A panel of lncRNAs could be useful as markers for detecting prostate cancer. Full Text | PDF
Non–small cell lung cancer (NSCLC) tumor heterogeneity as a predictor of disease outcomes doi:10.1038/scibx.2014.1307 Genomic sequencing studies suggest NSCLC intratumoral heterogeneity could help predict disease outcome. Full Text | PDF
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