Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The September 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with Viventia Bio Inc.
A conversation with Elias Zerhouni Steve Usdin doi:10.1038/scibx.2014.1252 Sanofi's Elias Zerhouni wants a dedicated national fund to keep young scientists involved in research, which he thinks should be the top policy priority for advancing biomedical innovation. Full Text | PDF
ACTing for NIH C. Simone Fishburn doi:10.1038/scibx.2014.1253 A new campaign to petition Congress to increase NIH funding has the backing of several academic heavyweights but stops short of defining how the money would be spent. Full Text | PDF
Greasing insulin Benjamin Boettner doi:10.1038/scibx.2014.1254 The once discarded target GPR120 has led to the discovery of an entirely new class of fatty acids that could restore insulin sensitivity in patients with diabetes. Full Text | PDF
AD goes 3D Lauren Martz doi:10.1038/scibx.2014.1255 A 3D neuronal culture model of Alzheimer's disease is much improved over earlier models, but researchers disagree on whether it is close enough to human disease for use in drug discovery. Full Text | PDF
Growth arrest and DNA-damage-inducible 45β (GADD45B); mitogen-activated protein kinase kinase 7 (MAP2K7; MKK7) doi:10.1038/scibx.2014.1256 Studies in patient samples and mice suggest inhibiting the GADD45B-MKK7 complex could help treat MM. Full Text | PDF
Sirtuin 1 (SIRT1); SIRT2 doi:10.1038/scibx.2014.1257 Cell culture and zebrafish studies suggest inhibiting SIRT1 could help treat metastatic Ewing's sarcoma. Full Text | PDF
Forkhead box O1 (FOXO1) doi:10.1038/scibx.2014.1258 Studies based on patient data and rodent models suggest the generic chemotherapy drug paclitaxel could help treat pulmonary arterial hypertension (PAH). Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1259 In vitro and pig studies suggest a perfluorodecalin coating for medical devices could help prevent thrombosis. Full Text | PDF
G protein–coupled receptor 120 (GPR120; O3FAR1) doi:10.1038/scibx.2014.1260 Mouse and human sample studies suggest a class of fatty acids could help treat diabetes. Full Text | PDF
Major histocompatibility complex class I A (HLA-A); HLA-B; HLA-C doi:10.1038/scibx.2014.1261 In vitro and mouse studies suggest transfusion with HLA-A/B/C− platelets generated from induced pluripotent stem (iPS) cells could help decrease platelet transfusion failures in patients with anti-HLA antibodies. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1262 In vitro and mouse studies suggest oligosaccharide-protein conjugates could help diagnose and prevent Brucella bacterial infections. Full Text | PDF
Cathelicidin antimicrobial peptide (CAMP; LL37) doi:10.1038/scibx.2014.1263 In vitro studies suggest nylon-3 polymers could help treat Clostridium difficile infection. Full Text | PDF
α-hemolysin (aHL) doi:10.1038/scibx.2014.1264 Cell culture and mouse studies suggest artificial liposomes could help treat Gram-positive bacterial infections by sequestering cytolytic toxins those pathogens secrete. Full Text | PDF
CD160 doi:10.1038/scibx.2014.1265 In vitro studies suggest inhibiting CD160 could help treat viral infections by promoting T cell function. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1266 Mouse studies suggest immunization with allergen peptides conjugated to a prodrug of α-galactosylceramide (αGC) could help treat allergen-induced asthma. Full Text | PDF
IL-33 (NF-HEV); tryptase doi:10.1038/scibx.2014.1267 In vitro and mouse studies suggest inhibiting tryptase and other IL-33-cleaving proteases produced by mast cells could help treat asthma. Full Text | PDF
Platelet derived growth factor BB (PDGF-BB); cathepsin K (CTSK) doi:10.1038/scibx.2014.1268 In vitro and mouse studies suggest increasing PDGF-BB levels could help treat osteoporosis. Full Text | PDF
Notch 1 (NOTCH1) doi:10.1038/scibx.2014.1269 Mouse studies suggest inhibiting NOTCH1 could help treat indications involving neuronal loss. Full Text | PDF
Driver-gene inference by genetic-genomics and information theory (DIGGIT) algorithm to identify disease driver mutations doi:10.1038/scibx.2014.1271 In vitro studies suggest network-based analysis with DIGGIT could help identify disease driver mutations. Full Text | PDF
3D neuronal culture model of Alzheimer's disease (AD) doi:10.1038/scibx.2014.1272 A 3D neuronal culture model of AD could help screen for new therapeutics. Full Text | PDF
Mutant neuroblastoma Ras viral (v-Ras) oncogene (Nras) mouse model of melanoma doi:10.1038/scibx.2014.1273 Mice expressing activating mutations in Nras could help identify new treatments for melanoma. Full Text | PDF
Adhesive polyvinyl alcohol (PVA)-chitosan films for sublingual drug delivery doi:10.1038/scibx.2014.1274 Cell and tissue culture studies suggest adhesive films composed of PVA and chitosan could be useful for sublingual drug delivery and sustained release of peptide and protein drugs. Full Text | PDF
Drug-silica nanoconjugates for tumor-specific delivery of cytotoxic agents doi:10.1038/scibx.2014.1275 Nanoconjugates with sizes optimized for tumor penetration and retention could safely deliver cytotoxic drugs to tumors. Full Text | PDF
Inhalable micelles expressing a lung-targeting peptide for delivery of therapies to treat pulmonary arterial hypertension (PAH) doi:10.1038/scibx.2014.1276 In vitro and mouse studies suggest lung-targeted peptide-micelle conjugates could help deliver therapies to treat lung diseases such as PAH. Full Text | PDF
Generation of endothelial colony–forming cells (ECFCs) from human pluripotent stem cells to treat ischemic cardiovascular diseases doi:10.1038/scibx.2014.1277 A protocol for generating cells similar to cord blood ECFCs from human pluripotent stem cells could be useful for developing cellular therapies to treat ischemic cardiovascular diseases. Full Text | PDF
Liposome-supported peritoneal dialysis for detoxification doi:10.1038/scibx.2014.1278 Rat studies suggest liposome-supported dialysis could be useful for extracting excess metabolites and drugs from the peritoneal cavity. Full Text | PDF
Synthetic aptamer-polymer hybrid constructs for targeted drug delivery to tumor cells doi:10.1038/scibx.2014.1279 Aptamer-polymer hybrid constructs could be useful for selective delivery of chemotherapeutic agents to tumor cells. Full Text | PDF
Melanin-based nanoparticles for multimodal imaging of melanoma tumors doi:10.1038/scibx.2014.1280 Melanin-based nanoparticles could be useful for imaging melanoma tumors in patients. Full Text | PDF
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