Nature Biotechnology Contents: Volume 32 pp 1067 - 1168

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TABLE OF CONTENTS November 2014 Volume 32, Issue 11 Editorial News Correction Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   NEW WHITE PAPER: The Advantage & Application of Genetically Humanized Mouse Models for Biomedical Research This paper explores the technologies used to generate genetically humanized mice and explores applications, including: Efficacy & Safety Testing of Therapeutic Compounds & Biologics Drug Metabolism & Disposition The Immune System Novel Therapeutic Approaches In Vivo Download Your Copy Today  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Collections  RNA Sequencing Quality Control (SEQC) Articles from Nature Biotechnology, Nature Communications and Scientific Data presents results from The RNA Sequencing Quality Control (SEQC) project. This is the second phase of a collaboration between government, academic and industry researchers as part of the MicroArray Quality Control (MAQC) consortium. Produced with support from the FDA's National Center for Toxicological Research (NCTR/FDA)  and the State Key Laboratory of Genetic Engineering (SKLGE) at Fudan University     Editorial Top Outpaced by an outbreak   p1067 doi:10.1038/nbt.3074 The international community's woeful response to the West African Ebola epidemic has been compounded by the lack of vaccines and therapies on the ground. That is why US government cutbacks to biodefense funding should be reevaluated and five-year funding tranches restored. News Top Landmark approvals in idiopathic pulmonary fibrosis   pp1069 - 1070 Mark Ratner doi:10.1038/nbt1114-1069 Takeda's second bet on DARTs   p1070 doi:10.1038/nbt1114-1070a Gilead's interferon-free HCV combo approved   p1070 doi:10.1038/nbt1114-1070b $675 million for MRSA antibiotic   p1070 doi:10.1038/nbt1114-1070c Novo sets sights on obesity market with diabetes drug   pp1071 - 1072 Cormac Sheridan doi:10.1038/nbt1114-1071 Dow's newly approved Enlist fights superweeds   p1073 doi:10.1038/nbt1114-1073b J&J buys antiviral firm Alios   p1073 doi:10.1038/nbt1114-1073c Illumina, Thermo Fisher build consortia to develop 'universal' cancer tests   pp1073 - 1074 Chris Morrison doi:10.1038/nbt1114-1073a Correction Top Correction   p1074 doi:10.1038/nbt1114-1074 News Top Anti-IL-5 biologics carve out severe-asthma niche   pp1075 - 1076 Elie Dolgin doi:10.1038/nbt1114-1075 Mouse mAb patent revoked   p1076 doi:10.1038/nbt1114-1076a EMA adopts transparency policy   p1076 doi:10.1038/nbt1114-1076b Australia upholds BRCA1 gene patent   p1076 doi:10.1038/nbt1114-1076c Big-cap buying bonanza trickles down to small biotech   pp1077 - 1078 Melanie Senior doi:10.1038/nbt1114-1077 Data Page Biotech on the bounce in 3Q14   p1079 Walter Yang doi:10.1038/nbt.3068 Drug pipeline 3Q14   p1080 Laura DeFrancesco doi:10.1038/nbt.3072 News Feature Technology comes to typing   pp1081 - 1084 Jeffrey L Fox doi:10.1038/nbt.3067 As mass spectrometry makes inroads into pathogen identification in the clinical laboratory, deep sequencing[mdash]even nanopore sequencing[mdash]is waiting in the wings. Jeffrey L. Fox investigates. Bioentrepreneur Top Data Page Top US universities and institutes for life sciences in 2013   p1085 Brady Huggett doi:10.1038/nbt.3066 Opinion and Comment Top Correspondence 3D printing for the many, not the few   pp1086 - 1087 James N Fullerton, George C M Frodsham and Richard M Day doi:10.1038/nbt.3056 Genetically engineered crops that fly under the US regulatory radar   pp1087 - 1091 Alex Camacho, Allen Van Deynze, Cecilia Chi-Ham and Alan B Bennett doi:10.1038/nbt.3057 Screening cellular metabolic activity   p1092 Bachir el Debs, Ramesh Utharala and Christoph A Merten doi:10.1038/nbt.3058 Gregory Stephanopoulos and colleagues reply to Screening cellular metabolic activity   pp1092 - 1093 doi:10.1038/nbt.3059 Features Top Patents Antibody claims granted by the European Patent Office   pp1094 - 1098 Hilary van der Hoff doi:10.1038/nbt.3054 A survey of the claims of antibody-related patents granted by the European Patent Office and a review of the type and scope of product claims granted for antibodies. Recent patent applications in neural engineering   p1099 doi:10.1038/nbt.3075 News and Views Top Closing in on pancreatic beta cells   pp1100 - 1102 Neil Hanley doi:10.1038/nbt.3064 Differentiation of human pluripotent stem cells toward pancreatic beta cells yields cells of increased maturity. See also: Research by Rezania et al. Antibacterials for any target   pp1102 - 1104 Lynn L Silver doi:10.1038/nbt.3060 RNA-guided nucleases provide a strategy for killing specific bacterial species in complex populations. See also: Research by Citorik et al. | Research by Bikard et al. Making biology transparent   pp1104 - 1105 Burkhard Hockendorf, Luke D Lavis and Philipp J Keller doi:10.1038/nbt.3061 The molecular and cellular architecture of the organs in a whole mouse is revealed through optical clearing. Biotechnology JOBS of the week Faculty Position in Biomaterials Ecole Polytechnique Fédérale de Lausanne (EPFL) Postdoctoral Scientist Seattle Biomedical Research Institute Data Science - Canada Research Chair Tier I University of British Columbia (UBC) Assistant Professor Arizona State University Postdoctoral opportunities in Bioinformatics La Jolla Institute for Allergy & Immunology More Science jobs from Biotechnology EVENT ICBB'15 - International Conference on Bioengineering and Biotechnology July 15, 2015 Barcelona, Spain More science events from Computational Biology Top Analysis Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads   pp1106 - 1112 Valenti Moncunill, Santi Gonzalez, Silvia Bea, Lise O Andrieux, Itziar Salaverria et al. doi:10.1038/nbt.3027 A new approach overcomes the hurdles of identifying large, complex structural variants in cancer genomes by directly comparing tumor and normal genome sequencing reads. Research Top Perspective Allosteric targeting of receptor tyrosine kinases   pp1113 - 1120 Frederik De Smet, Arthur Christopoulos and Peter Carmeliet doi:10.1038/nbt.3028 Articles Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells   pp1121 - 1133 Alireza Rezania, Jennifer E Bruin, Payal Arora, Allison Rubin, Irina Batushansky et al. doi:10.1038/nbt.3033 A seven-stage protocol enables differentiation of human embryonic stem cells into cells similar to pancreatic beta cells. See also: News and Views by Hanley A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling   pp1134 - 1140 Daniel C Leslie, Anna Waterhouse, Julia B Berthet, Thomas M Valentin, Alexander L Watters et al. doi:10.1038/nbt.3020 A non-stick surface coating makes medical devices anti-thrombogenic and resistant to biofilm growth. Letters Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases   pp1141 - 1145 Robert J Citorik, Mark Mimee and Timothy K Lu doi:10.1038/nbt.3011 Delivery of CRISPR-Cas nucleases using bacteriophage enables targeted killing of microbes in a population See also: News and Views by Silver Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials   pp1146 - 1150 David Bikard, Chad W Euler, Wenyan Jiang, Philip M Nussenzweig, Gregory W Goldberg et al. doi:10.1038/nbt.3043 Coupling the specificity of CRISPR-Cas nucleases and bacteriophage delivery enables exquisitely precise bacterial killing. See also: News and Views by Silver Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells   pp1151 - 1157 Nutan Prasain, Man Ryul Lee, Sasidhar Vemula, Jonathan Luke Meador, Momoko Yoshimoto et al. doi:10.1038/nbt.3048 Endothelial cells with properties of cord-blood endothelial colony-forming cells are generated from human pluripotent stem cells. Resources Comparative analyses of C4 and C3 photosynthesis in developing leaves of maize and rice   pp1158 - 1165 Lin Wang, Angelika Czedik-Eysenberg, Rachel A Mertz, Yaqing Si, Takayuki Tohge et al. doi:10.1038/nbt.3019 Efforts to improve the efficiency of photosynthesis in crop plants will benefit from a resource of transcriptomic and metabolomic data on maize and rice. Errata Erratum: Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study   p1166 Sheng Li, Scott W Tighe, Charles M Nicolet, Deborah Grove, Shawn Levy et al. doi:10.1038/nbt1114-1166a Erratum: High-resolution metagenomics   p1166 Eran Mick and Rotem Sorek doi:10.1038/nbt1114-1166b Erratum: Public biotech 2013[mdash]the numbers   p1166 Stacy Lawrence and Riku Lahteenmaki doi:10.1038/nbt1114-1166c Corrigendum Corrigendum: Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells   p1166 Peter W Andrews, Joy Cavanagro, Robert Deans, Ellen Feigel, Ed Horowitz et al. doi:10.1038/nbt1114-1166d Careers and Recruitment Top Third-quarter biotech job picture   p1167 Michael Francisco doi:10.1038/nbt.3065 People People   p1168 doi:10.1038/nbt.3076 Top Advertisement Poster & Webcast on CRISPR-Cas technology from Nature Publishing Group Nature Reviews Microbiology  FREE POSTER CRISPR-Cas: extraordinary editing  Presented by Nature Biotechnology  Webcast and live Q&A: A practical guide to CRISPR technology Date: November 25, 2014 Poster and Webcast produced with support from  OriGene, Your Gene Company      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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