EMBO reports Table of Contents for November 2014; Vol. 15, No. 11

November 2014 | Volume 15, Number 11 Submit Table of Contents Editorial Correspondence Opinion Science & Society Reviews Scientific Reports Corrigenda Volume 15, Number 11 Editorial No more Mr Nasty Howy is stepping down as Chief Editor of EMBO Reports in the new year and takes the opportunity to reflect on the editorial process and future opportunities. Howy Jacobs Published online 05.11.2014 Correspondence Beyond the IF boycott: Let's think about counter‐incentives against illegitimate co‐authorship A comment on “The porisoners' dilemmas”. Péter Kakuk Published online 13.10.2014 Authorship inflation is unethical The response by David Shaw. David Shaw Published online 13.10.2014 Opinion The steps from translatable to translational research A scheme to better classify the steps from basic research to translational research would help to avoid confusion and enable administrators and funders to describe an institute's research profile. Frank Gannon Published online 08.10.2014 Science & Society Networking in academia: Generating and enhancing relationships with your acquaintances and colleagues will create a diverse network of sponsors eager to help you succeed Building a network to give you an edge is as important for scientists in academia as it is for those in industry. So how do you make it a mutually beneficial experience? Jennifer Streeter Published online 15.10.2014 Reawakening anaesthesia research: Anaesthesia—one of the greatest achievements of medicine—remains unexplained, but a slew of new studies may help to solve the mystery An explosion of studies on the molecular mechanism of anaesthetics and their effect on neural circuits is bringing us closer to solving the long‐standing scientific puzzle of how anaesthesia actually works. Andrea Rinaldi Published online 13.10.2014 Rules of engagement: Restricting security‐sensitive research data—a European view The recent debate about gain‐of‐function experiments with pathogens has raised the issue of how the legal system should weigh biosecurity concerns against academic freedom. Johannes Rath Published online 14.10.2014 Turning nature's inspiration into a production line: Exploits of natural designs have become a systematic research field to create new materials and designs for architecture, medicinal devices and other products Our fascination with the ingenuity of nature has led to its own field of research, and scientists are bringing new products and materials inspired by the natural world to market. Philip Hunter Published online 13.10.2014 Reviews Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human The Notch pathway regulates normal and malignant hematopoiesis. This review discusses recent developments in understanding the role of Notch in the human hematopoietic system with special emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Rahul Kushwah, Borhane Guezguez, Jung Bok Lee, Claudia I Hopkins, and Mickie Bhatia Published online 24.09.2014 Senescence and apoptosis: dueling or complementary cell fates? In contrast to apoptosis, senescent cells are viable and can affect other cells through secreted factors. They could thus be the preferred cell fate for tumor suppression, wound healing and, intriguingly, during development. Bennett G Childs, Darren J Baker, James L Kirkland, Judith Campisi, and Jan M van Deursen Published online 13.10.2014 Scientific Reports Direct interaction of actin filaments with F‐BAR protein pacsin2 Actin polymerization together with proteins that directly deform membranes, such as BAR domain‐containing proteins, have been implicated in regulation of membrane shape. This study shows that the F‐BAR domain of pacsin2 binds actin filaments using the same concave surface employed to bind to membranes. Julius Kostan, Ulrich Salzer, Albina Orlova, Imre Törö, Vesna Hodnik, Yosuke Senju, Juan Zou, Claudia Schreiner, Julia Steiner, Jari Meriläinen, Marko Nikki, Ismo Virtanen, Oliviero Carugo, Juri Rappsilber, Pekka Lappalainen, Veli‐Pekka Lehto, Gregor Anderluh, Edward H Egelman, and Kristina Djinović‐Carugo Published online 12.09.2014 SET8 methyltransferase activity during the DNA double‐strand break response is required for recruitment of 53BP1 This study demonstrates that SET8 is actively recruited to DNA double‐strand breaks and that its methyltransferase activity is needed to recruit 53BP1. These activities are required for double strand break repair, primarily via the NHEJ pathway. Stanimir Dulev, Johnny Tkach, Sichun Lin, and Nizar N Batada Published online 24.09.2014 HDAC4 promotes Pax7‐dependent satellite cell activation and muscle regeneration HDAC4 is shown to promote damage‐induced satellite cell (SC) proliferation and muscle regeneration in vivo by stimulating Pax7 expression. It also prevents aberrant lipid accumulation and induction of the brown fat transcription factor Prdm16 in regenerating muscle. Moon‐Chang Choi, Soyoung Ryu, Rui Hao, Bin Wang, Meghan Kapur, Chen‐Ming Fan, and Tso‐Pang Yao Published online 09.09.2014 Ack kinase regulates CTP synthase filaments during Drosophila oogenesis DAck kinase is shown to localize to CTP synthase (CTPS) filaments in germ cells of the Drosophila ovary. DAck catalytic activity is required for normal CTPS filament morphology and CTP‐dependent processes such as RNA production, plasma membrane integrity and fertility. Todd I Strochlic, Kevin P Stavrides, Sam V Thomas, Emmanuelle Nicolas, Alana M O'Reilly, and Jeffrey R Peterson Published online 15.09.2014 Gcn5 and PCAF negatively regulate interferon‐β production through HAT‐independent inhibition of TBK1 This study shows that, contrary to the current model and despite their recruitment to the IFNB promoter, Gcn5 and PCAF negatively regulate IFN‐β production. They do so in a histone acetyltransferase‐independent manner, through the inhibition of TBK1. Qihuang Jin, Lenan Zhuang, Binbin Lai, Chaochen Wang, Wenqian Li, Brian Dolan, Yue Lu, Zhibin Wang, Keji Zhao, Weiqun Peng, Sharon YR Dent, and Kai Ge Published online 30.09.2014 Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis This study shows that heterotrimeric G proteins modulate stem cell proliferation in the plant shoot apical meristem via CLAVATA signaling pathway and provides evidence that that CLV3 peptide receptor RPK2 is a novel G protein‐coupled receptor. Takashi Ishida, Ryo Tabata, Masashi Yamada, Mitsuhiro Aida, Kanako Mitsumasu, Masayuki Fujiwara, Katsushi Yamaguchi, Shuji Shigenobu, Masayuki Higuchi, Hiroyuki Tsuji, Ko Shimamoto, Mitsuyasu Hasebe, Hiroo Fukuda, and Shinichiro Sawa Published online 26.09.2014 Iro/IRX transcription factors negatively regulate Dpp/TGF‐β pathway activity during intestinal tumorigenesis Iro/Irx transcription factors are shown to suppress the TGF‐β pathway, reducing its tumor suppressor activity in flies and human cells. They could thus enable tumor growth in the presence of TGF‐β, before mutations in this pathway occur. Òscar Martorell, Francisco M Barriga, Anna Merlos‐Suárez, Camille Stephan‐Otto Attolini, Jordi Casanova, Eduard Batlle, Elena Sancho, and Andreu Casali Published online 08.10.2014 Corrigenda Peer review: rigor? Or rigor mortis? Vytas A Bankaitis Published online 05.11.2014 Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo Hanneke Vlaming, Tibor van Welsem, Erik L de Graaf, David Ontoso, AF Maarten Altelaar, Pedro A San‐Segundo, Albert JR Heck, and Fred van Leeuwen Published online 05.11.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.