The EMBO Journal Table of Contents for 16 October 2014; Vol. 33, No. 20

16 October 2014 | Volume 33, Number 20 Submit Table of Contents Have you seen? Review Articles Volume 33, Number 20 Have you seen? Stem cell competition: how speeding mutants beat the rest A new study on clonal tracing in human tissue validates the concept of neutral competition, earlier revealed by genetic manipulation in various model organisms. Edward R Morrissey and Louis Vermeulen Published online 01.09.2014 LRRK2 directing ER‐to‐Golgi transport? (ER)yES! The function of the Parkinson's disease‐associated kinase LRRK2 and the pathogenic mechanisms of LRRK2 genetic mutations remain poorly understood. A novel role for LRRK2 at ER exit sites to regulate COPII‐dependent anterograde trafficking has now been revealed. Bingwei Lu Published online 08.09.2014 Deep diving in the blood stem cell‐ome An integrated ‐omics analysis of hematopoietic stem‐ and progenitor populations offers unprecedented insights into their regulatory networks at the molecular, cellular and epigenetic level. Demetrios Kalaitzidis and David T Scadden Published online 04.09.2014 Review Scaling of immune responses against intracellular bacterial infection Percy Knolle and Zeinab Abdullah discuss how pattern recognition receptors and signaling pathways contribute to the scaling of immune responses against intracellular bacterial infection. Zeinab Abdullah and Percy A Knolle Published online 15.09.2014 Articles Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo By extension of the neutral drift paradigm to Drosophila cytoplast stem cells, the outcome of cellular competition is shown to be determined by proliferative responses downstream of Hedgehog and Hippo signaling. Marc Amoyel, Benjamin D Simons, and Erika A Bach Published online 04.08.2014 Leucine‐rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export Parkinson's disease (PD)‐associated LRRK2 functions by associating with Sec16A at ER exit sites, facilitating COPII‐mediated anterograde vesicle transport; a PD‐associated LRRK2 mutant lacks this function. Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu, and Huaibin Cai Published online 08.09.2014 Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex By recruiting SWI/SNF chromatin remodellers to NF‐κB, the conserved nuclear protein Akirin2 stimulates pro‐inflammatory gene promoters in mouse macrophages during innate immune responses to viral or bacterial infection. Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M Standley, Jules A Hoffmann, Jean‐Marc Reichhart, Shizuo Akira, and Osamu Takeuchi Published online 08.08.2014 Akirin specifies NF‐κB selectivity of Drosophila innate immune response via chromatin remodeling The nuclear factor Akirin orchestrates NF‐κB transcriptional selectivity through the recruitment of the Osa‐containing‐SWI/SNF Brahma complex (BAP), by activating a subset of NF‐κB effector genes. François Bonnay, Xuan‐Hung Nguyen, Eva Cohen‐Berros, Laurent Troxler, Eric Batsche, Jacques Camonis, Osamu Takeuchi, Jean‐Marc Reichhart, and Nicolas Matt Published online 01.09.2014 Discrete Notch signaling requirements in the specification of hematopoietic stem cells This paper dissects the contributions of discrete Notch‐signaling events during HSC generation. Albert D Kim, Chase H Melick, Wilson K Clements, David L Stachura, Martin Distel, Daniela Panáková, Calum MacRae, Lindsey A Mork, J Gage Crump, and David Traver Published online 17.09.2014 HSF1 deficiency and impaired HSP90‐dependent protein folding are hallmarks of aneuploid human cells Altered gene expression and proteostasis in human cells bearing defined aneuploidies derive from decreased heat shock response induction, and can be rescued by overexpression of the master transcription factor HSF1. Neysan Donnelly, Verena Passerini, Milena Dürrbaum, Silvia Stingele, and Zuzana Storchová Published online 09.09.2014 Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death Excitotoxicity leads to mitochondrial fragmentation, altered calcium homeostasis and neuronal death in two phases: a reversible Drp1‐dependent one, followed by the irreversible degradation of MEF2, causing reduced Mfn2 transcription and Bax translocation to mitochondria. Alejandro Martorell‐Riera, Marc Segarra‐Mondejar, Juan P Muñoz, Vanessa Ginet, Jordi Olloquequi, Jeús Pérez‐Clausell, Manuel Palacín, Manuel Reina, Julien Puyal, Antonio Zorzano, and Francesc X Soriano Published online 21.08.2014 Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures X‐ray structures of rhomboid protease GlpG complexed to substrate‐derived peptide inhibitors provide direct insights into substrate binding and mechanism of an intramembrane protease. Sebastian Zoll, Stancho Stanchev, Jakub Began, Jan Škerle, Martin Lepšík, Lucie Peclinovská, Pavel Majer, and Kvido Strisovsky Published online 12.09.2014 DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA Crystal structures reveal the importance of a novel, conserved interface through which the dimeric MRN complex subunit Mre11 binds a single molecule of longer DNA representing its physiological substrate. Sihyun Sung, Fuyang Li, Young Bong Park, Jin Seok Kim, Ae‐Kyoung Kim, Ok‐kyu Song, Jiae Kim, Jun Che, Sang Eun Lee, and Yunje Cho Published online 08.08.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.