Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The September 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with Kymab Ltd.
Biopharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The September 2014 issue of Biopharma Dealmakers showcases companies with partnering opportunities. This week, find out about how you can collaborate with PlantForm Corporation
Redistributing BRD4 in inflammation Kai-Jye Lou doi:10.1038/scibx.2014.1223 A new link between inflammation and atherosclerosis centers on the BET bromodomain protein BRD4 and could provide new targets for intervention. Full Text | PDF
The ALS bucket brigade Benjamin Boettner doi:10.1038/scibx.2014.1224 The ALS Association is allocating the first funds from its ice bucket challenge to create four new research alliances that focus on genetics and biomarkers for the disease. Full Text | PDF
Bayer's Bay Area formula Stephen Parmley doi:10.1038/scibx.2014.1225 Bayer is emphasizing alliances rather than money to tap into Bay Area innovation. Full Text | PDF
Sex matters at the NIH Lauren Martz doi:10.1038/scibx.2014.1226 The NIH is taking steps to make the inclusion of both sexes in preclinical studies a standard practice. Full Text | PDF
HER2 (EGFR2; ErbB2; neu); Erbb2 interacting protein (ERBB2IP; ERBIN) doi:10.1038/scibx.2014.1227 Cell-based, primary tumor and mouse studies suggest inhibiting ERBIN could help treat HER2-driven luminal breast cancers. Full Text | PDF
Mdm2 p53 binding protein homolog (MDM2; HDM2); p53 doi:10.1038/scibx.2014.1228 Mouse and in vitro studies have identified an MDM2 inhibitor that could help treat breast cancers regardless of p53 status. Full Text | PDF
MicroRNA-100 (miR-100) doi:10.1038/scibx.2014.1229 Cell-based, primary tumor and mouse studies suggest promoting miR-100 expression could help treat breast cancer. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1230 In vitro studies suggest an osmium(VI) nitrido complex targeting cancer stem cells (CSCs) could help treat breast cancer. Full Text | PDF
AXL receptor tyrosine kinase (AXL; UFO); growth arrest–specific 6 (GAS6) doi:10.1038/scibx.2014.1231 In vitro and mouse studies suggest an AXL-Fc fusion protein could help prevent cancer metastasis. Full Text | PDF
Programmed cell death 1 (PDCD1; PD-1; CD279); programmed cell death 1 ligand 1 (PD-L1; B7-H1; CD274) doi:10.1038/scibx.2014.1232 Mouse studies suggest combining radiotherapy with inhibitors of PD-1 or PD-L1 could help treat cancer. Full Text | PDF
Zinc finger CCCH-type antiviral 1 (ZC3HAV1; ZAP) doi:10.1038/scibx.2014.1233 In vitro and mouse studies suggest an oncolytic alphavirus could help treat cancers expressing low levels of ZAP. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1235 Mouse studies suggest the mitochondria-targeted coenzyme Q10 analog mitoquinone could help treat obesity. Full Text | PDF
Enterococcus faecalis endocarditis and biofilm-associated pilus subunit A (ebpA) doi:10.1038/scibx.2014.1236 In vitro and mouse studies suggest an ebpA-based vaccine could help prevent catheter-associated urinary tract infection (CAUTI) caused by E. faecalis. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1237 Cell culture and mouse studies suggest Streptococcus pneumoniae capsular polysaccharides conjugated to the lipid antigen α-galactosylceramide (αGC) could help protect against S. pneumoniae infection. Full Text | PDF
CXC chemokine receptor 1 (CXCR1); CXCR2 (IL8RB) doi:10.1038/scibx.2014.1238 In vitro and mouse studies suggest a new class of dual CXCR1 and CXCR2 inhibitors could help treat inflammatory diseases. Full Text | PDF
SMAD family member 1 (MADH1; SMAD1) MADH5 (SMAD5); MADH9 (SMAD9; SMAD8) doi:10.1038/scibx.2014.1239 Mouse studies suggest promoting ATP hydrolysis or inhibiting SMAD1, SMAD5 and SMAD8 could help treat injury-associated heterotopic ossification (HO). Full Text | PDF
Wingless-type MMTV integration site family member 16B (WNT16B) doi:10.1038/scibx.2014.1240 Rodent studies suggest WNT16B could help prevent bone loss and consequent bone fractures. Full Text | PDF
Legumain (LGMN; AEP); microtubule-associated protein-τ (MAPT; tau; FTDP-17) doi:10.1038/scibx.2014.1241 In vitro, patient sample and mouse studies suggest inhibiting AEP could help treat AD. Full Text | PDF
Progranulin (PGRN; PCDGF) doi:10.1038/scibx.2014.1242 Mouse studies suggest increasing PGRN levels in the brain could help treat AD. Full Text | PDF
Not applicable doi:10.1038/scibx.2014.1243 In vitro and rodent studies suggest analogs of octanoic acid could help treat epilepsy. Full Text | PDF
High mobility group box 1 (HMGB1); HMGB2 doi:10.1038/scibx.2014.1244 Cell culture and mouse studies have identified a small molecule called inflachromene that could help treat neuroinflammation. Full Text | PDF
κ-opioid receptor (OPRK1; KOR) doi:10.1038/scibx.2014.1245 Mouse studies suggest the G protein–biased KOR agonists could help treat pain with fewer side effects than other classes of KOR agonists. Full Text | PDF
Unknown doi:10.1038/scibx.2014.1246 Mouse and flatworm studies have identified sulfido-conjugated compounds in human milk that could help promote tissue repair following infection or ischemia. Full Text | PDF
Aptamer-mediated detection of low-epitope targets using organic receptor derivatization agents doi:10.1038/scibx.2014.1247 In vitro studies suggest aptamer-mediated detection of low-epitope molecules such as monosaccharides could help diagnostics development. Full Text | PDF
Cellular thermal shift assay (CETSA) to identify drug targets doi:10.1038/scibx.2014.1248 A CETSA that detects ligand binding could help check for off-target binding and identify biomarkers during drug development. Full Text | PDF
Genome-scale modulation of transcription with clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing doi:10.1038/scibx.2014.1249 Genome-scale modulation of transcription with CRISPR-Cas9 genome editing could help identify gene and gene transcript functions. Full Text | PDF
Disease models generated by clustered, regularly interspaced short palindromic repeats (CRISPR) genome editing in transgenic Cas9–expressing mice doi:10.1038/scibx.2014.1250 CRISPR-Cas9 genome editing could be used to generate mouse models of cancer and other diseases. Full Text | PDF
In vitro generation of insulin-producing cells from human pluripotent stem cells to treat type 1 diabetes doi:10.1038/scibx.2014.1251 An in vitro protocol to generate insulin-producing cells from human pluripotent stem cells could be useful for developing cellular therapies to treat type 1 diabetes. Full Text | PDF
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant)
Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA
Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston
Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.
No comments:
Post a Comment