Nature Reviews Immunology Contents November 2014 Volume 14 Number 11 pp 713-774

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TABLE OF CONTENTS
November 2014 Volume 14 Number 11
Impact Factor 33.836 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: 25-Hydroxycholesterols in innate and adaptive immunity Jason G. Cyster, Eric V. Dang, Andrea Reboldi & Tangsheng Yi
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Dendritic cells and macrophages in the kidney: a spectrum of good and evil   Renal dendritic cells and macrophages are key factors in the initiation and propagation of renal disease and tissue regeneration. This Review discusses the characteristics of dendritic cells and macrophages as well as current understanding of the renal-specific functions of these important phagocytic, antigen-presenting cell types in potentiating or mitigating intrinsic kidney disease.   Read this Review FREE online
RESEARCH HIGHLIGHTS Top Macrophages: Innate memory training p713 | doi:10.1038/nri3759 Epigenetic remodelling and changes in cellular metabolism are required for memory-like responses in innate immune cells. PDF Neonatal immunity: Babies' T cells can fight p714 | doi:10.1038/nri3758 CD4+ T cells in newborn babies show increased production of CXCL8, which could be important for defence against infections. PDF Tolerance: AIREs and graces p714 | doi:10.1038/nri3762 Distinct subsets of thymic antigen-presenting cells contribute to the generation of a diverse and self-tolerant T cell repertoire. PDF Microbiota: Support your friends to resist your enemies p715 | doi:10.1038/nri3765 Fucosylation of intestinal epithelial cells in response to commensal or systemic bacterial stimulation promotes disease resistance and tolerance through the metabolic support of the gut microbiota. PDF Natural killer cells: RAG keeps natural killers fit p716 | doi:10.1038/nri3760 Recombination-activating gene (RAG) proteins determine functional specialization and cellular fitness in natural killer cells. PDF Pattern recognition receptors: Picking LOX to find antibodies p716 | doi:10.1038/nri3764 LOX1 activates dendritic cells and B cells to boost humoral immune responses. PDF Neutrophils: Sizing up pathogens p717 | doi:10.1038/nri3756 Whether neutrophils kill a pathogen by phagocytosis or NETosis is determined by pathogen size. PDF Immunology JOBS of the week Postdoctoral Position in Immunology and Stem Cell Biology Washington University School of Medicine Immuno-Oncology Discovery Research Scientist Johnson & Johnson Pharmaceutical Research & Development One Post-Doc Position Available In The IMMUNE REGULATION Group At DRFZ Berlin Deutsches Rheuma-Forschungszentrum Berlin Postdoctoral Fellow University of Wisconsin - Madison More Science jobs from Immunology EVENT Global summit on Virology 27.08.15 Dubai, Saudi Arabia More science events from
REVIEWS		Top
Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell? Taku Kambayashi & Terri M. Laufer p719 | doi:10.1038/nri3754 Although the MHC class II-mediated modulation of CD4+ T cell responses is typically associated with dendritic cells, macrophages and B cells, other cell populations are also suggested to show such behaviour. The authors discuss these atypical antigen-presenting cells and question their relevance to immune responses in vivo. Abstract | Full Text | PDF
25-Hydroxycholesterols in innate and adaptive immunity Jason G. Cyster, Eric V. Dang, Andrea Reboldi & Tangsheng Yi p731 | doi:10.1038/nri3755 The closely related oxysterols, 25-hydroxycholesterol and 7α,25-dihydroxycholesterol, have important functions in innate and adaptive immune responses, ranging from antiviral and inflammation-regulatory effects to a role as a guidance cue for B cells and dendritic cells. Abstract | Full Text | PDF
Innate sensing of malaria parasites Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald & Douglas T. Golenbock p744 | doi:10.1038/nri3742 Malaria infections can result in deleterious activation of innate immune cells. In this Review, the authors summarize how the Plasmodium parasite is recognized by innate immune receptors, and discuss the role of these receptors in host resistance to infection and in the pathogenesis of malaria. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Regulated cell death and inflammation: an auto-amplification loop causes organ failure Andreas Linkermann, Brent R. Stockwell, Stefan Krautwald & Hans-Joachim Anders p759 | doi:10.1038/nri3743 In this Opinion article, the authors discuss how the induction of regulated cell death and inflammatory pathways may lead to an auto-amplification loop that causes tissue damage and organ failure. They propose that targeting both processes could be useful for treating a broad range of clinical conditions with an inflammatory basis. Abstract | Full Text | PDF | Supplementary information
OPINION T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Daniel E. Speiser, Daniel T. Utzschneider, Susanne G. Oberle, Christian Münz, Pedro Romero & Dietmar Zehn p768 | doi:10.1038/nri3740 Chronic viral infections and malignant tumours are associated with the development of T cells that have an 'exhausted' phenotype and that are thought to be severely functionally impaired. In this Opinion article, the authors propose that the exhausted phenotype is actually a functional adaptation to cause minimal tissue damage while still mediating a critical level of pathogen control. Abstract | Full Text | PDF
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