Nature Reviews Genetics Contents November 2014 Volume 15 Number 11 pp 703-776

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TABLE OF CONTENTS
November 2014 Volume 15 Number 11
Impact Factor 39.794 *	In this issue Research Highlights Reviews Analysis Also this month Article series: Study designs Modes of transcriptional regulation Applications of next-generation sequencing  Featured article: Evolutionary dynamics of coding and non-coding transcriptomes Anamaria Necsulea & Henrik Kaessmann
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RESEARCH HIGHLIGHTS Top Epigenetics: H3K27 methylation in transgenerational epigenetic memory p703 | doi:10.1038/nrg3848 PDF Evolution: A fishy tale of adaptive radiation p704 | doi:10.1038/nrg3835 PDF Non-coding RNA: A match made by crosslinking p704 | doi:10.1038/nrg3842 PDF RNA: Pseudouridylation of mRNAs — not so pseudo p705 | doi:10.1038/nrg3834 PDF Disease genetics: Searching large and small p706 | doi:10.1038/nrg3840 PDF Plant genetics: Following the early root of plastome degradation p706 | doi:10.1038/nrg3843 PDF Alternative splicing: Characterizing cell fate p706 | doi:10.1038/nrg3847 PDF IN BRIEF Plant genomics: The wild side of soybeans | Human evolution: Who do you think you are? | Translation: To each their own — use of distinct tRNA pools | Development: Daddy issues — paternal contribution in plants | Alternative splicing: Retaining introns to sculpt gene expression | Cancer: Up and down for DNA methylation inhibitors | RNA: Dissecting circular RNA biogenesis PDF Genetics JOBS of the week Assistant Professor in Human Genetics University of Texas Southwestern Medical Center Lecturer or Senior Lecturer in Quantitative Genetics University of Otago Scientist Position in Human Molecular Genetics University of Toronto Tenure-Track Faculty Positions (Assistant / Associate / Full Professor)Yale University, Department of Genetics Yale University School of Medicine Research Associate - Gene Therapy Center University of Massachusetts More Science jobs from Genetics EVENT Malaria Experimental Genetics 15.03.15 Bangkok, Thailand More science events from
REVIEWS		Top
Article series: Study designs Identifying and mitigating bias in next-generation sequencing methods for chromatin biology Clifford A. Meyer & X. Shirley Liu p709 | doi:10.1038/nrg3788 Next-generation sequencing methods can be used to examine features of chromatin biology, although the outputs of these methods can be subject to various potential biases. This Review describes the ways in which biases can be introduced to such experiments and outlines methods to detect and mitigate their effect. Abstract | Full Text | PDF
Detecting epistasis in human complex traits Wen-Hua Wei, Gibran Hemani & Chris S. Haley p722 | doi:10.1038/nrg3747 Genome-wide association studies have been extensively used to uncover genetic variants that independently influence complex traits, including diseases. This Review describes advances in computational approaches to detect interactions (epistasis) between genetic variants underlying complex traits, including the different promises and pitfalls of the methods. Additionally, the authors summarize current empirical evidence on how pervasive epistasis is in complex traits and its wider biological implications. Abstract | Full Text | PDF | Supplementary information
Article series: Modes of transcriptional regulation Evolutionary dynamics of coding and non-coding transcriptomes Anamaria Necsulea & Henrik Kaessmann p734 | doi:10.1038/nrg3802 This Review provides insights obtained from comparative transcriptomic studies of mammalian species. The dynamics of gene expression evolution in coding and non-coding genes, as well as the regulatory basis of transcriptome evolution and future research avenues, are discussed. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Sequencing pools of individuals [mdash] mining genome-wide polymorphism data without big funding Christian Schlötterer, Raymond Tobler, Robert Kofler & Viola Nolte p749 | doi:10.1038/nrg3803 This Review describes how whole-genome sequencing of pooled DNA from many individuals (Pool-seq) is an economical alternative to sequencing the genomes of individuals separately. The authors outline the strengths and pitfalls of Pool-seq, and provide example applications across diverse species and biological questions. Abstract | Full Text | PDF
ANALYSIS		Top
The contribution of genetic variants to disease depends on the ruler John S. Witte, Peter M. Visscher & Naomi R. Wray p765 | doi:10.1038/nrg3786 There are various measures to quantify the contribution of genetic variants to disease risk, but differing terminology and assumptions obfuscate their use and interpretation. In this Analysis, the authors consider and contrast six commonly used measures that assess disease risk of individual variants, and provide numerical examples in breast cancer, Crohn's disease, rheumatoid arthritis and schizophrenia. Abstract | Full Text | PDF | Supplementary information
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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