Nature Cell Biology contents: November 2014 Volume 16 Number 11, pp 1029 - 1126

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Advertisement CRISPR/Cas9 monoclonal antibody now available Diagenode now offers the first monoclonal antibody against CRISPR/Cas9 Better performance that tag antibodies Validated for all major applications such as immunoblot, immunoprecipitation, and IF Recognizes Cas9 and dCas9  Learn more TABLE OF CONTENTS November 2014 Volume 16, Issue 11 News and Views Articles Letter Corrigendum Retractions Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Medical Research Masterclass From the basic functions of the cell to cures for HIV and cancer, Nature Outlook: Medical Research Masterclass uses the 2014 Lindau Nobel Laureate Meeting as a basis to explore the latest research in medicine and physiology.  Access the Outlook free online for six months. Supported by Mars, Incorporated     News and Views Top Milk makes lysosomes lethal   pp1029 - 1031 Shefali Krishna and Michael Overholtzer doi:10.1038/ncb3059 Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases. See also: Article by Sargeant et al. Cyclin C surprises in tumour suppression   pp1031 - 1033 Marianna Trakala and Marcos Malumbres doi:10.1038/ncb3055 Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway. See also: Article by Li et al. Cell Biology JOBS of the week Postdoctoral position in Single-Cell Biology of the Nucleus Karolinska Institutet (KI) Postdoctoral Fellow: Gene Regulation in Breast Cancer / Stem Cell Biology UC College of Medicine Chairperson, Department of Cell Biology Rowan University Faculty Position in Mesenchymal Progenitor, Differentiation, or Stem Cell Biology Duke University Assistant Professor- Stem and / or Progenitor Cell Biology Vanderbilt University Medical Center More Science jobs from Cell Biology EVENT Cell Biology of the Heart: Beyond the Myocyte-Centric View 01.03.15 Copper Mountain, USA More science events from Advertisement Validated ChIP antibodies you can TRUST — and try a sample! Partnering with epigenetics experts in the BLUEPRINT epigenome consortium, Diagenode has developed completely validated epigenetics antibodies with the highest specificity and sensitivity available. Achieve unparalleled MeDIP, ChIP, and ChIP-seq results with validated antibodies you can trust.  Learn more and try a sample today.   Articles Top Pri peptides are mediators of ecdysone for the temporal control of development   pp1035 - 1044 Hélène Chanut-Delalande, Yoshiko Hashimoto, Anne Pelissier-Monier, Rebecca Spokony, Azza Dib et al. doi:10.1038/ncb3052 Payre and colleagues identify a gene, GstE14, needed for production of the insect steroid hormone ecdysone and find that this hormone acts through Pri peptides to control the timing of differentiation events. Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells   pp1045 - 1056 Cristina Ottone, Benjamin Krusche, Ariadne Whitby, Melanie Clements, Giorgia Quadrato et al. doi:10.1038/ncb3045 Parrinello and colleagues show that direct interactions with endothelial cells in the subventricular zone maintain the quiescence and identity of neural stem cells, through a process involving both Notch- and Ephrin-mediated signalling pathways. Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization   pp1057 - 1068 Timothy J. Sargeant, Bethan Lloyd-Lewis, Henrike K. Resemann, Antonio Ramos-Montoya, Jeremy Skepper et al. doi:10.1038/ncb3043 Lysosomal membrane permeabilization releases cathepsins to promote cell death and mammary gland involution. Sargeant et al. report that Stat3-driven phagocytic uptake of fatty acids in milk triglycerides permeabilizes lysosomes to induce cell death. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo   pp1069 - 1079 William E. Dowdle, Beat Nyfeler, Jane Nagel, Robert A. Elling, Shanming Liu et al. doi:10.1038/ncb3053 Murphy and colleagues generate an inhibitor of the lipid kinase VPS34, which they use to uncover autophagy substrates. One of their targets, NCOA4, regulates iron homeostasis by binding ferritin heavy chain-1 and targeting ferritin to autolysosomes. Cyclin C is a haploinsufficient tumour suppressor   pp1080 - 1091 Na Li, Anne Fassl, Joel Chick, Hiroyuki Inuzuka, Xiaoyu Li et al. doi:10.1038/ncb3046 Through gene knockout experiments, Sicinski and colleagues reveal a role for cyclin C as a haploinsufficient tumour suppressor in T-cell acute lymphoblastic leukaemia, acting through phosphorylation of intracellular Notch1, mediating its degradation. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1   pp1092 - 1104 Yihua Wang, Fangfang Bu, Christophe Royer, Sébastien Serres, James R. Larkin et al. doi:10.1038/ncb3050 Lu and colleagues report that ASPP2 induces mesenchymal–epithelial transition and inhibits cancer cell invasion and metastasis by preventing the β-catenin-mediated upregulation of ZEB1. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages   pp1105 - 1117 Haihui Lu, Karl R. Clauser, Wai Leong Tam, Julia Fröse, Xin Ye et al. doi:10.1038/ncb3041 Weinberg and colleagues report that monocytes and macrophages interact with stem-like human mammary epithelial cells to create a breast cancer stem cell niche. Advertisement Fluorescence is at your fingertips with ZOE™, a benchtop cell imager you control by touch screen. Features brightfield illumination and three fluorescent channels. Step out of the darkroom, see the light!   Letter Top Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein   pp1118 - 1124 Takayuki Torisawa, Muneyoshi Ichikawa, Akane Furuta, Kei Saito, Kazuhiro Oiwa et al. doi:10.1038/ncb3048 Furuta and colleagues report that single dynein molecules are kept in an autoinhibited state through the stacking of their two head domains. This autoinhibition is relieved when dynein molecules assemble together on cargo. Corrigendum Top Corrigendum: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis   p1125 Valerie S. LeBleu, Joyce T. O'Connell, Karina N. Gonzalez Herrera, Harriet Wikman, Klaus Pantel et al. doi:10.1038/ncb3056 Retractions Top Retraction: DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs   p1126 Toru Fukuda, Kaoru Yamagata, Sally Fujiyama, Takahiro Matsumoto, Iori Koshida et al. doi:10.1038/ncb3061 See also: Letter by Fukuda et al. Retraction: Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade   p1126 Miyuki Suzawa, Ichiro Takada, Junn Yanagisawa, Fumiaki Ohtake, Satoko Ogawa et al. doi:10.1038/ncb3068 See also: Letter by Suzawa et al. Retraction: A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation   p1126 Ichiro Takada, Masatomo Mihara, Miyuki Suzawa, Fumiaki Ohtake, Shinji Kobayashi et al. doi:10.1038/ncb3069 See also: Article by Takada et al. Top Advertisement A picture of health Reporter Lorna Stewart travels to the German island of Lindau to meet 600 of science’s brightest young minds and 37 rock stars – Nobel laureates. In a series of four films, Stewart asks some of the most profound questions in medicine.  Watch the videos online.  Published weekly from 24th Sep- 15th Oct 2014 Supported by Mars, Incorporated     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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