Nature Biotechnology Contents: Volume 32 pp 961 - 1066

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Advertisement Coming soon: The CPN Challenge.  The mission of Conquer Paralysis Now is to find a cure. We're so serious about this, we're about to launch a major series of grants and cash prizes to the researchers and teams who can get us there. Take your place as a solver history will remember. Watch for CPN Challenge details at conquerparalysisnow.org. TABLE OF CONTENTS October 2014 Volume 32, Issue 10 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   NEW WHITE PAPER: An Overview of Humanized Mouse Models for Experimental Medicine This paper provides an overview of mouse model humanization, genetically humanized mice, and the impact to the study of human genes. Download this paper to learn: Principles of mouse model humanization How to generate genetically humanized mice Application areas for humanized mice >>Download Now Japanese table of contents Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Complete Genome Editing Solutions GeneCopoeia provides complete genome editing solutions, including CRISPR products and services TALEN & TALE-TF construction services Donor construction service and cloning vectors Stable cell line services Transgenic mouse services  Register our FREE webinar to learn more.   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Communications soon to be fully open access   From 20th October Nature Communications, will become fully open access for all new submissions. If an author has a manuscript they wish to submit to the journal via the subscription route, they must submit before 20th October. After this date all new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For any questions on the switch, open access or advice on policies and funding, visit our website, read the press release or contact our dedicated support team at openaccess@nature.com.   Editorial Top Time to deliver   p961 doi:10.1038/nbt.3045 Drug delivery research requires an injection of new thinking. Fostering closer ties with cell biologists seeking to unravel membrane trafficking is a good place to start. News Top First PI3k inhibitor launches into crowded hematology markets   pp963 - 964 Chris Morrison doi:10.1038/nbt1014-963 Electric Grand Prix cars to be powered by algae-based generators   p965 doi:10.1038/nbt1014-965b Student-led startup Covagen snapped up by J&J   p965 doi:10.1038/nbt1014-965c Actionable Genome Consortium to guide NGS in cancer   p965 doi:10.1038/nbt1014-965d Apple moves on health, drug developers shift into smart gear   pp965 - 966 Cormac Sheridan doi:10.1038/nbt1014-965a NIH issues genomic data sharing policy   p966 doi:10.1038/nbt1014-966a Vertex buries Incivek   p966 doi:10.1038/nbt1014-966b Exelixis slashes 70% of staff   p966 doi:10.1038/nbt1014-966c Pharma partners with efforts to pool patient genotype and phenotype data   p967 Mark Ratner doi:10.1038/nbt1014-967 Insomniacs get new mechanism sleep drug Belsomra   p968 Cormac Sheridan doi:10.1038/nbt1014-968 NRC revisits GE crop risks   p969 Lisa Melton doi:10.1038/nbt1014-969a BGI, Imperial and Waters   p969 doi:10.1038/nbt1014-969b Beat beer spoilers   p969 doi:10.1038/nbt1014-969c First stem cell—derived islets in humans   p969 doi:10.1038/nbt1014-969d Novartis wades into stem cell therapies   p969 doi:10.1038/nbt1014-969e Gaucher's disease oral therapy gets nod from FDA   pp970 - 971 Gunjan Sinha doi:10.1038/nbt1014-970 Second MRSA antibiotic reaches the market   p972 Jeffrey L Fox doi:10.1038/nbt1014-972 The price of priority review: $67.5 million   p973 Melanie Senior doi:10.1038/nbt1014-973 Around the world in a month   p974 doi:10.1038/nbt1014-974 Bioentrepreneur Top Building a business Corporate venture capital and Cambridge   pp975 - 978 Margaret G McCammon, Edwina Pio, Shima Barakat and Shailendra Vyakarnam doi:10.1038/nbt.3029 Podcast First Rounders Podcast: Mary Tanner   p978 doi:10.1038/nbt.3032 Opinion and Comment Top Correspondence Nature's contribution to today's pharmacopeia   pp979 - 980 Lin Tao, Feng Zhu, Chu Qin, Cheng Zhang, Feng Xu et al. doi:10.1038/nbt.3034 Development of the clinical next-generation sequencing industry in a shifting policy climate   pp980 - 982 Margaret A Curnutte, Karen L Frumovitz, Juli M Bollinger, Amy L McGuire and David J Kaufman doi:10.1038/nbt.3030 Commentary Restoring the pharmaceutical industry's reputation   pp983 - 990 Mark Kessel doi:10.1038/nbt.3036 Big pharma's storehouse of trouble has fostered consumer mistrust and a negative view of the industry. How does the industry go about restoring its flagging reputation? Features Top Biopharmaceutical benchmarks 2014   pp992 - 1000 Gary Walsh doi:10.1038/nbt.3040 Monoclonal antibodies continue their march on the markets, optimized so-called biobetter versions of existing biologics are also gaining ground, but the rate of biosimilar approvals has seen a dramatic slowdown in recent years. Patents The scope of patent protection for gene technology in China   pp1001 - 1003 Wei Li and LiSheng Cai doi:10.1038/nbt.3031 The scope of protection for gene technology patents in China is still narrow compared with that of Europe and the United States. Recent patent applications in three-dimensional cell culture   p1004 doi:10.1038/nbt.3047 News and Views Top How deep is enough in single-cell RNA-seq?   pp1005 - 1006 Aaron M Streets and Yanyi Huang doi:10.1038/nbt.3039 Guidelines for determining sequencing depth facilitate transcriptome profiling of single cells in heterogeneous populations. See also: Research by Pollen et al. A blueprint of cell identity   pp1007 - 1008 Avi Ma'ayan and Qiaonan Duan doi:10.1038/nbt.3035 Research on converting one cell type to another will be aided by systematic mapping of the gene-regulatory networks in mammalian cells. Miniaturizing wireless implants   pp1008 - 1010 Henry Mei and Pedro P Irazoqui doi:10.1038/nbt.3038 A breakthrough in wireless power transfer enables smaller implantable devices, opening the door to new applications. Research Highlights   p1010 doi:10.1038/nbt.3042 Biotechnology JOBS of the week Postdoctoral Researcher in Biochemistry & Biophysics Ludwig-Maximilians Universitaet Muenchen, Germany PhD Position in Biochemistry / Functional Proteomics Universität Freiburg University Professor of Biochemistry University of Innsbruck, Austria Assistant Professor of Biochemistry University of Washington Institute for Protein Design Bioinformatics Analyst Cancer Research UK Cambridge Institute More Science jobs from Biotechnology EVENT FT Global Pharmaceutical and Biotechnology Conference 2014 November 17, 2014 London, UK More science events from Computational Biology Top Analysis Enzyme clustering accelerates processing of intermediates through metabolic channeling   pp1011 - 1018 Michele Castellana, Maxwell Z Wilson, Yifan Xu, Preeti Joshi, Ileana M Cristea et al. doi:10.1038/nbt.3018 An elegant mathematical model supported by experiments in Escherichia coli demonstrates how clustering enzymes can efficiently channel intermediates from one enzyme to the next, facilitating rational engineering of metabolism. Research Top Articles Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping   pp1019 - 1025 Paula J P de Vree, Elzo de Wit, Mehmet Yilmaz, Monique van de Heijning, Petra Klous et al. doi:10.1038/nbt.2959 Chromatin crosslinking facilitates the detection in selected genomic regions of structural variants missed by existing approaches Generation of the epicardial lineage from human pluripotent stem cells   pp1026 - 1035 Alec D Witty, Anton Mihic, Roger Y Tam, Stephanie A Fisher, Alexander Mikryukov et al. doi:10.1038/nbt.3002 The ability to generate epicardial cells from human pluripotent stem cells will facilitate studies of heart regeneration. Global analysis of protein structural changes in complex proteomes   pp1036 - 1044 Yuehan Feng, Giorgia De Franceschi, Abdullah Kahraman, Martin Soste, Andre Melnik et al. doi:10.1038/nbt.2999 Coupling limited proteolysis and a proteomics workflow enables measurement of both subtle and wholesale protein conformational changes in a eukaryotic proteome. De novo assembly of soybean wild relatives for pan-genome analysis of diversity and agronomic traits OPEN   pp1045 - 1052 Ying-hui Li, Guangyu Zhou, Jianxin Ma, Wenkai Jiang, Long-guo Jin et al. doi:10.1038/nbt.2979 Sequencing and de novo assembly of seven wild relatives of soybean yields insights relevant to crop domestication and improvement. Letters Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex   pp1053 - 1058 Alex A Pollen, Tomasz J Nowakowski, Joe Shuga, Xiaohui Wang, Anne A Leyrat et al. doi:10.1038/nbt.2967 Pollen et al. show that low-coverage RNA sequencing of single cells is a powerful approach for characterizing heterogeneous cell populations. See also: News and Views by Streets & Huang Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates   pp1059 - 1062 Robert P Lyon, Jocelyn R Setter, Tim D Bovee, Svetlana O Doronina, Joshua H Hunter et al. doi:10.1038/nbt.2968 A new method for linking antibodies to drugs produces conjugates with improved stability and efficacy. Careers and Recruitment Top Bridging the gap between invention and commercialization in medical devices   pp1063 - 1065 Avik Som, Tauseef Charanya, Stephen W Linderman and Joshua S Siegel doi:10.1038/nbt.3041 At Washington University, students and faculty have addressed challenges surrounding biomedical innovation and training through a novel and low-cost platform. People People   p1066 doi:10.1038/nbt.3046 Top Advertisement Call for Papers Nature Plants: From Bench to Biosphere Nature Plants is now open for submissions and welcomes manuscripts from all areas of plant research. Submit your research online today! View the complete Guide to Authors     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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