Laboratory Investigation - Table of Contents alert Volume 94 Issue 11

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TABLE OF CONTENTS Volume 94, Issue 11 (November 2014) In this issue Inside the USCAP Journals Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2014 94: 1186-1187; 10.1038/labinvest.2014.127 Full Text Research Articles Top BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Lactoferrin suppresses the Epstein–Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9 Epstein-Barr virus (EBV) triggers innate immune and inflammatory responses partly through toll-like receptor (TLR) signaling. This study shows that lactoferrin can interfere with the activation of TLR2 and TLR9 by EBV and thereby reduce the synthesis of interleukin-8 and monocyte chemoattractant protein-1. Thus, lactoferrin may be a preventive treatment for diseases related to EBV-infection. Ying Zheng, Zailong Qin, Qiurong Ye, Pan Chen, Zhen Wang, Qun Yan, Zhaohui Luo, Xiaoping Liu, Yanhong Zhou, Wei Xiong, Jian Ma and Guiyuan Li 2014 94: 1188-1199; advance online publication, July 28, 2014; 10.1038/labinvest.2014.105 Abstract | Full Text Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction This paper reveals the role of the Tim-3/galectin-9 system in the regulation of inflammatory bone destruction mediated by osteoclasts. Galectin-9 directly suppress osteoclastogenesis through its receptor, Tim-3, which is expressed on the cell surface of osteoclast precursors. The inflammatory bone destruction seen in rheumatoid arthritis might be ameliorated by controlling the Tim-3/galectin-9 system. Kanako Moriyama, Akiko Kukita, Yin-Ji Li, Norihisa Uehara, Jing-Qi Zhang, Ichiro Takahashi and Toshio Kukita 2014 94: 1200-1211; advance online publication, September 29, 2014; 10.1038/labinvest.2014.107 Abstract | Full Text CXCL12+ stromal cells as bone marrow niche for CD34+ hematopoietic cells and their association with disease progression in myelodysplastic syndromes Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell diseases that eventually result in leukemic transformation. This study shows that CXCL12+ cells constitute a niche in the bone marrow for CD34+ hematopoietic progenitor cells, and may be associated with the survival of CD34+ cells and disease progression in MDS. CXCL12+ cells may therefore represent a novel MDS therapeutic target. Shiho Abe-Suzuki, Morito Kurata, Shinya Abe, Iichiroh Onishi, Susumu Kirimura, Manami Nashimoto, Toshihiko Murayama, Michihiro Hidaka and Masanobu Kitagawa 2014 94: 1212-1223; advance online publication, September 8, 2014; 10.1038/labinvest.2014.110 Abstract | Full Text Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice Frontotemporal dementia (FTD) is a neurodegenerative disease caused by mutations in the progranulin gene (GRN), resulting in reduced progranulin expression in neurons and microglia. The authors demonstrate that wild-type bone marrow transplant (BMT) delivers progranulin into brain tissue and partially reverses neuroinflammation in progranulin-deficient mice. BMT shows promise as a stem cell-based approach to prevent or to treat neurodegenerative diseases. Yue Yang, Macarena S Aloi, Eiron Cudaback, Samuel R Josephsen, Samantha J Rice, Nikolas L Jorstad, C Dirk Keene and Thomas J Montine 2014 94: 1224-1236; advance online publication, September 8, 2014; 10.1038/labinvest.2014.113 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression An imbalance in protease and antiprotease activities is a cornerstone of idiopathic pulmonary fibrosis (IPF) pathogenesis. This paper shows that protease nexin-1 (PN-1) is overexpressed in lungs and bronchoalveolar lavage fluids of patients with IPF, which leads to inhibition of thrombin and upregulation of fibronectin. Uncovering the role of PN-1 in IPF lung remodeling may be helpful in the design of new therapeutic approaches. Déborah François, Laurence Venisse, Joëlle Marchal-Somme, Martine Jandrot-Perrus, Bruno Crestani, Véronique Arocas and Marie-Christine Bouton 2014 94: 1237-1246; advance online publication, September 8, 2014; 10.1038/labinvest.2014.111 Abstract | Full Text Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis This paper describes the classification of a new cell population derived from the lung, called “lung mixed culture-derived epithelial cells” (LMDEC). LMDEC have a unique profile of cell lineage markers and the capacity to differentiate into type I alveolar epithelial cells. The study also shows that engraftment of LMDEC delivers a protective effect against chemically induced lung injury in mice. Kensuke Tanaka, Tetsuo Fujita, Hiroki Umezawa, Kana Namiki, Kento Yoshioka, Masahiko Hagihara, Tatsuhiko Sudo, Sadao Kimura, Koichiro Tatsumi and Yoshitoshi Kasuya 2014 94: 1247-1259; advance online publication, September 8, 2014; 10.1038/labinvest.2014.109 Abstract | Full Text ORAL, GASTROINTESTINAL AND HEPATIC SYSTEMS MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells MFG-E8 promotes clearance of apoptotic cells by bridging phosphatidylserine on apoptotic cells and integrin αvβ3/5 on phagocytes. Because MFG-E8 is overexpressed in several types of cancer, the authors examined its role in oral squamous cell carcinoma (SCC). They found that MFG-E8 appears to be involved in the clearance of apoptotic SCC cells by living SCC cells, and also promotes tumor progression. Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Ahmed Essa, Hamzah Babkair, Jun Cheng and Takashi Saku 2014 94: 1260-1272; advance online publication, September 29, 2014; 10.1038/labinvest.2014.108 Abstract | Full Text Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis This paper characterizes a novel mouse model that combines atherosclerosis and nonalcoholic fatty liver disease in order to study liver tumorogenesis. The authors show that the NF-κB, Stat3, JNK, and AKT signaling pathways, in combination with enhanced inflammation, appear to be crucial for tumor development. Marian Kampschulte, Christiane Stöckl, Alexander C Langheinrich, Ulrike Althöhn, Rainer M Bohle, Gabriele A Krombach, Philipp Stieger, Yuri Churin, Sandra Kremer, Christian Dierkes, Timo Rath, Elke Roeb and Martin Roderfeld 2014 94: 1273-1282; advance online publication, September 8, 2014; 10.1038/labinvest.2014.112 Abstract | Full Text Expression and distribution of immunoglobulin G in the normal liver, hepatocarcinoma and postpartial hepatectomy liver This paper reveals that IgG is expressed in the cytoplasm of normal adult human hepatocytes, rat hepatocytes, normal and neoplastic liver cell lines, and the hepatocytes of immunodeficient mice. The authors propose that IgG expression is related to hepatocyte growth and proliferation, which may have profound clinical implications. Yu Lei, Tao Huang, Meng Su, Jin Luo, Christine Korteweg, Jing Li, Zhengshan Chen, Yamei Qiu, Xingmu Liu, Meiling Yan, Yun Wang and Jiang Gu 2014 94: 1283-1295; advance online publication, September 29, 2014; 10.1038/labinvest.2014.114 Abstract | Full Text MODELS AND TECHNIQUES Antagonism of Ang-Tie2 and Dll4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method Controlling tumor angiogenesis is a promising anti-cancer strategy. The authors describe a new flow cytometry approach that precisely measures tumorassociated endothelial cell (TAEC) proliferation from xenograft tissues. The method's usefulness was demonstrated by blocking Ang-Tie2 and Dll4-Nocth signaling pathways with two distinct antiangiogenic agents, which shows opposing effects on TAEC proliferation. Marc Payton, Toni Jun, William Wayne, Dongyin Yu, Raffi Manoukian, Grace Chung, Nancy Zhang, Ji-Rong Sun, Paula Kaplan-Lefko, Sheila Scully, Gwyneth Van, Robert Radinsky, Richard Kendall, Jonathan Oliner and Angela Coxon 2014 94: 1296-1308; advance online publication, September 22, 2014; 10.1038/labinvest.2014.116 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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