The EMBO Journal Table of Contents for 1 September 2014; Vol. 33, No. 17

1 September 2014 | Volume 33, Number 17 Submit Table of Contents Have you seen? Articles Resource Corrigendum Retraction Volume 33, Number 17 Have you seen? Traffic control: adaptor proteins guide dynein–cargo takeoff Two papers published in The EMBO Journal and Science show that reconstituted human microtubule motor protein dynein is highly processive in the presence of its activator dynactin as well as adaptor proteins. Michael A Cianfrocco and Andres E Leschziner Published online 24.07.2014 Sharpening rhomboid specificity by dimerisation and allostery The finding that allosteric cooperation between rhomboid protease dimers aids specific recognition of physiological substrates offers new concepts in the understanding of intramembrane proteolysis. Kvido Strisovsky and Matthew Freeman Published online 15.07.2014 Stop competing, start talking! A screen revealing coupling of apoptosis and checkpoint adaptation pathways calls for reevaluation of the competing network model for explaining the fate of cells upon extended mitotic arrest. Luca L Fava and Andreas Villunger Published online 25.07.2014 Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia KIF7 is a conserved kinesin involved in Hh signaling that associates with microtubule plus‐ends in cilia to regulate axonemal stability and length, and to generate a cilia‐tip compartment where Gli proteins processing is regulated. Ganesh V Pusapati and Rajat Rohatgi Published online 17.07.2014 Articles In vitro reconstitution of a highly processive recombinant human dynein complex Cargo adaptor BICD2 converts dynein from a non‐processive to a highly processive motor in presence of dynactin. This might coordinate long‐distance movement with cargo availability. Max A Schlager, Ha Thi Hoang, Linas Urnavicius, Simon L Bullock, and Andrew P Carter Published online 01.07.2014 Allosteric regulation of rhomboid intramembrane proteolysis Homotropic allosteric communication between rhomboid dimers controls efficient cleavage of cognate transmembrane substrate while being dispensable for proteolysis of generic soluble substrates. Elena Arutyunova, Pankaj Panwar, Pauline M Skiba, Nicola Gale, Michelle W Mak, and M Joanne Lemieux Published online 09.07.2014 TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis Immunologic tolerance to intestinal microbiota depends on Rab11 endosome‐mediated control of pathogen pattern recognition receptor TLR9 processing and signaling. Shiyan Yu, Yingchao Nie, Byron Knowles, Ryotaro Sakamori, Ewa Stypulkowski, Chirag Patel, Soumyashree Das, Veronique Douard, Ronaldo P Ferraris, Edward M Bonder, James R Goldenring, Yicktung Tony Ip, and Nan Gao Published online 24.07.2014 A virus capsid‐like nanocompartment that stores iron and protects bacteria from oxidative stress Bacteria compartmentalize by sequestering components into protein shells. Here, such a nanocompartment is shown to structurally resemble virus capsids and to store large amounts of iron for protection under starvation conditions. Colleen A McHugh, Juan Fontana, Daniel Nemecek, Naiqian Cheng, Anastasia A Aksyuk, J Bernard Heymann, Dennis C Winkler, Alan S Lam, Joseph S Wall, Alasdair C Steven, and Egbert Hoiczyk Published online 14.07.2014 K‐Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation The histone acetyltransferase KAT2A emerges as a novel key regulator of hippocampal memory consolidation in mice, controlling gene expression linked to neuroactive ligand–receptor signaling in association with NF‐κB. Roman M Stilling, Raik Rönicke, Eva Benito, Hendrik Urbanke, Vincenzo Capece, Susanne Burkhardt, Sanaz Bahari‐Javan, Jonas Barth, Farahnaz Sananbenesi, Anna L Schütz, Jerzy Dyczkowski, Ana Martinez‐Hernandez, Cemil Kerimoglu, Sharon YR Dent, Stefan Bonn, Klaus G Reymann, and Andre Fischer Published online 14.07.2014 Dok1 and Dok2 proteins regulate natural killer cell development and function The adaptor proteins Dok1 and Dok2 regulate natural killer‐cell activation and maturation. Javier Celis‐Gutierrez, Marilyn Boyron, Thierry Walzer, Pier Paolo Pandolfi, Stipan Jonjić, Daniel Olive, Marc Dalod, Eric Vivier, and Jacques A Nunès Published online 24.06.2014 The NB‐LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance Plant microbial resistance is mediated by a pair of interacting immune sensors, RGA4 and RGA5. RGA4 mediates cell death but is repressed by RGA5. The repressor is neutralized by binding of pathogen‐derived proteins to the dimer. Stella Césari, Hiroyuki Kanzaki, Tadashi Fujiwara, Maud Bernoux, Véronique Chalvon, Yoji Kawano, Ko Shimamoto, Peter Dodds, Ryohei Terauchi, and Thomas Kroj Published online 14.07.2014 Resource Genome‐wide siRNA screen reveals coupling between mitotic apoptosis and adaptation An RNAi screen offers new insights into the regulatory networks governing the fate of cancer cells undergoing prolonged drug‐induced mitotic checkpoint arrest. Laura A Díaz‐Martínez, Zemfira N Karamysheva, Ross Warrington, Bing Li, Shuguang Wei, Xian‐Jin Xie, Michael G Roth, and Hongtao Yu Published online 14.07.2014 Corrigendum Natural IgG antibodies provide innate protection against ficolin‐opsonized bacteria Saswati Panda, Jing Zhang, Nguan Soon Tan, Bow Ho, and Jeak Ling Ding Published online 01.09.2014 Retraction Retraction: ‘A cell cycle regulatory network controlling NF‐κB subunit activity and function’ Benjamin Barré and Neil D Perkins Published online 28.07.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.