Scientific Reports Biology Table of Contents e-alert: 2 September 2014

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02 September 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies ▶     Bing Liu, Divesh Bhatt, Zoltán N. Oltvai et al.     Developing pharmacological strategies for controlling ionizing radiation (IR)-induced cell death is important for both mitigating radiation damage and alleviating the side effects …             MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8 ▶     Minyu Wang, Jilin Wang, Xuan Kong et al.     In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation …             Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies ▶     Francisco J. Sánchez-Luque, Michael Stich, Susanna Manrubia et al.     The human immunodeficiency virus type-1 (HIV-1) genome contains multiple, highly conserved structural RNA domains that play key roles in essential viral processes. Interference …             Brain Mass and Cranial Nerve Size in Shrews and Moles ▶     Duncan B. Leitch, Diana K. Sarko, Kenneth C. Catania     We investigated the relationship between body size, brain size, and fibers in selected cranial nerves in shrews and moles. Species include tiny masked shrews (S. cinereus) …             Effective connectivity during animacy perception – dynamic causal modelling of Human Connectome Project data ▶     Hauke Hillebrandt, Karl J. Friston, Sarah-Jayne Blakemore     Biological agents are the most complex systems humans have to model and predict. In predictive coding, high-level cortical areas inform sensory cortex about incoming sensory …             Association between the IL1B, IL1RN polymorphisms and COPD risk: A meta-analysis ▶     Zi-Kang Xie, Qiu-Pin Huang, Jian Huang et al.     The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a …             ERRATUM: Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation ▶     Munerah Hamed, Saadia Khilji, Jihong Chen et al.                 Co-option of the polarity gene network shapes filament morphology in angiosperms ▶     Ana Maria Rocha de Almeida, Roxana Yockteng, James Schnable et al.     The molecular genetic mechanisms underlying abaxial-adaxial polarity in plants have been studied as a property of lateral and flattened organs, such as leaves. In leaves, laminar …             Quantification of surface tension and internal pressure generated by single mitotic cells ▶     Elisabeth Fischer-Friedrich, Anthony A. Hyman, Frank Jülicher et al.     During mitosis, adherent cells round up, by increasing the tension of the contractile actomyosin cortex while increasing the internal hydrostatic pressure. In the simple scenario …             ERRATUM: Using sociometers to quantify social interaction patterns ▶     Jukka-Pekka Onnela, Benjamin N. Waber, Alex Pentland et al.                 The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications ▶     Gérrard Eddy Jai Poinern, Ravi Krishna Brundavanam, Xuan Thi Le et al.     Hydroxyapatite (HAP) is a biocompatible ceramic that is currently used in a number of current biomedical applications. Recently, nanometre scale forms of HAP have attracted …             Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes ▶     Koji Ueda, Nobuhisa Ishikawa, Ayako Tatsuguchi et al.     Exosome-mediated signal transportation plays a variety of critical roles in cancer progression and metastasis. From the aspect of cancer diagnosis, circulating exosomes are ideal …             Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis ▶     Li Li, Liyan Wang, Zhiqin Wu et al.     Edible berries have a broad spectrum of biomedical functions, including improving immune responses and reducing risk for chronic diseases. In this study, the anti-inflammatory …             Local Nash Equilibrium in Social Networks ▶     Yichao Zhang, M. A. Aziz-Alaoui, Cyrille Bertelle et al.     Nash equilibrium is widely present in various social disputes. As of now, in structured static populations, such as social networks, regular, and random graphs, the discussions on …             Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice ▶     M. H. Dijkstra, E. Pirinen, J. Huusko et al.     Vascular endothelial growth factor-B (VEGF-B) has been implicated to play a significant role in coronary vessel growth and endothelial uptake and transport of fatty acids in heart …             Body height affects the strength of immune response in young men, but not young women ▶     Indrikis A. Krams, Ilona Skrinda, Sanita Kecko et al.     Body height and other body attributes of humans may be associated with a diverse range of social outcomes such as attractiveness to potential mates. Despite evidence that each …             Stiff substrates enhance cultured neuronal network activity ▶     Quan-You Zhang, Yan-Yan Zhang, Jing Xie et al.     The mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that …             Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability ▶     Jia Li, Fei Liu, Qi Wang et al.     The emergence and rapid spread of New Delhi Metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae strains has caused a great concern worldwide. To better understand the …             A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment ▶     Haixu Chen, Sihan Wang, Jing Zhang et al.     Critical limb ischaemia is the most severe clinical manifestation of peripheral arterial disease. The circulating endothelial progenitor cells (EPCs) play important roles in …             Network Science and the Effects of Music Preference on Functional Brain Connectivity: From Beethoven to Eminem ▶     R. W. Wilkins, D. A. Hodges, P. J. Laurienti et al.     Most people choose to listen to music that they prefer or ‘like’ such as classical, country or rock. Previous research has focused on how different characteristics of music (i.e., …             Personalized Metabolomics for Predicting Glucose Tolerance Changes in Sedentary Women After High-Intensity Interval Training ▶     Naomi L. Kuehnbaum, Jenna B. Gillen, Martin J. Gibala et al.     High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet …             LASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma ▶     Tsair-Fwu Lee, Ming-Hsiang Liou, Yu-Jie Huang et al.     To predict the incidence of moderate-to-severe patient-reported xerostomia among head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC) patients treated …             Microbial communities evolve faster in extreme environments ▶     Sheng-Jin Li, Zheng-Shuang Hua, Li-Nan Huang et al.     Evolutionary analysis of microbes at the community level represents a new research avenue linking ecological patterns to evolutionary processes, but remains insufficiently …             Critical limitations of consensus clustering in class discovery ▶     Yasin Șenbabaoğlu, George Michailidis, Jun Z. Li     Consensus clustering (CC) has been adopted for unsupervised class discovery in many genomic studies. It calculates how frequently two samples are grouped together in repeated …             Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies ▶     Yasuhiro Kazuki, Yuwna Yakura, Satoshi Abe et al.     Infants with Down syndrome (DS) are at a high risk of developing transient abnormal myelopoiesis (TAM). A GATA1 mutation leading to the production of N-terminally truncated GATA1 …             Alternating images of congruent and incongruent movement creates the illusion of agency ▶     Takumi Yokosaka, Hiroyuki Iizuka, Tomoko Yonemura et al.     We report a novel illusion whereby people perceive both congruent and incongruent hand motions as a united, single, and continuous motion of one's own hand (i.e. a sense of …             Tear proteomic analysis of Sjögren syndrome patients with dry eye syndrome by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry ▶     Bing Li, Minjie Sheng, Jianhua Li et al.     We examined the tear film proteome of patients with Sjögren's syndrome (SS) and dry eye syndrome (group A), patients with dry eye symptoms (group B) and normal volunteers (group …             Axon Injury and Regeneration in the Adult Drosophila ▶     Lorena Soares, Michael Parisi, Nancy M. Bonini     Neural regeneration is a fascinating process with profound impact on human health, such that defining biological and genetic pathways is of interest. Here we describe an in vivo …             A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs ▶     Tian Liu, Peng Guo, Yong Zhou et al.     Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously …             CORRIGENDUM: Fluorescence-based visualization of autophagic activity predicts mouse embryo viability ▶     Satoshi Tsukamoto, Taichi Hara, Atsushi Yamamoto et al.                 GluCl a target of indole alkaloid okaramines: a 25 year enigma solved ▶     Shogo Furutani, Yuri Nakatani, Yuka Miura et al.     In 1989, indole alkaloid okaramines isolated from the fermentation products of Penicillium simplicissimum were shown to be insecticidal, yet the mechanism of their toxicity to …             Novel 3D Microscopic Analysis of Human Placental Villous Trees Reveals Unexpected Significance of Branching Angles ▶     Eva Haeussner, Antonia Buehlmeyer, Christoph Schmitz et al.     The villous trees of human placentas delineate the fetomaternal border and are complex three-dimensional (3D) structures. Thus far, they have primarily been analyzed as thin, …             Spatial heterogeneity of gut microbiota reveals multiple bacterial communities with distinct characteristics ▶     Hsiao-Pei Lu, Yung-Chih Lai, Shiao-Wei Huang et al.     We analyzed bacterial communities of six distinct gut sites (the food bolus and mucus layer of the proximal small intestine, cecum and distal large intestine), using wild …             Mis-splicing of the ABCC2 gene linked with Bt toxin resistance in Helicoverpa armigera ▶     Yutao Xiao, Tao Zhang, Chenxi Liu et al.     Toxins from the bacterium Bacillus thuringiensis (Bt) are used widely for insect control in sprays and transgenic plants, but their efficacy is reduced when pests evolve …             Nanoscale Label-free Bioprobes to Detect Intracellular Proteins in Single Living Cells ▶     Wooyoung Hong, Feng Liang, Diane Schaak et al.     Fluorescent labeling techniques have been widely used in live cell studies; however, the labeling processes can be laborious and challenging for use in non-transfectable cells, …             Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process ▶     Dorota Sikora, Lynda Rocheleau, Earl G. Brown et al.     The influenza A virus RNA polymerase cleaves the 5′ end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of …             Processing and characterisation of a novel electropolymerized silk fibroin hydrogel membrane ▶     Hai-Yan Wang, Yu-Qing Zhang     Silk fibroin can be made into various forms of biocompatible medical materials, including hydrogel due to its excellent properties. Here, we report a novel method for the …             The primary transcriptome of the marine diazotroph Trichodesmium erythraeum IMS101 ▶     Ulrike Pfreundt, Matthias Kopf, Natalia Belkin et al.     Blooms of the dinitrogen-fixing marine cyanobacterium Trichodesmium considerably contribute to new nitrogen inputs into tropical oceans. Intriguingly, only 60% of the …                 Nature Biotechnology ANIMATION: ANTIBODY-DRUG CONJUGATES   The challenges facing targeted delivery of antibody-drug conjugates to a tumor are presented in a 3D animation that describes some of the mechanisms by which these agents target cells.   Animation by Nucleus Inc.   Produced with support from Daiichi Sankyo and Takeda Pharmaceuticals         • Careers & Jobs           naturejobs.com Science jobs of the week       Postdoctoral Research Associate in Cellular / Molecular Biology of the B-MYB Transcription Factor     King's College London            Metabolic modeller (5064)     VTT Technical Research Centre of Finland            University Assistant (prae doc) at the Department of Biological Chemistry     University of Vienna (Universitaet Wien)            Postdoctoral Research Assistant in Organic Chemistry     University of Oxford            PhD Fellowship: Mathematical Modelling of Measures Supporting Eelgrass Recovery     University of Southern Denmark            Electrophysiologist to Study Ion Channel Dysfunction in Neurological Disorders     Institute of Organic Chemistry and Biochemistry AS CR            PhD in Pharmacy and Pharmaceutical Science     Cardiff University            Postdoctoral Fellow     Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital            Postdoctoral Associate     Baylor College of Medicine (BCM)            Postdoctoral Position in Bacterial Microcompartment Engineering     Michigan State University          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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