Nature Reviews Molecular Cell Biology contents October 2014 Volume 15 Number 10 pp 629-698

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TABLE OF CONTENTS
October 2014 Volume 15 Number 10
Impact Factor 36.458 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Technologies and techniques  Featured article: Mitochondrial dynamics and inheritance during cell division, development and disease Prashant Mishra & David C. Chan
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RESEARCH HIGHLIGHTS Top Cell death: RIPK1 protects epithelial cells p629 | doi:10.1038/nrm3876 RIPK1 can inhibit apoptosis and necroptosis through a kinase-independent scaffolding function, which is important for maintaining epithelial homeostasis. PDF Gene regulation: Yin and Yang of Polycomb/Trithorax response elements p630 | doi:10.1038/nrm3868 A PRE/TRE is shown to alter gene expression by transcribing two mutually exclusive ncRNAs from opposing DNA strands in different tissues during development. The transcription activating ncRNA was shown to bind PcG in vivo and to inhibit its function. PDF Protein folding: Structure-function analysis of KDM2A p630 | doi:10.1038/nrm3870 The substrate specificity of the histone Lys demethylase KDM2A was elucidated by solving its crystal structure in complex with methylated peptides. Follow-up structure-guided mutant analyses substantiated its roles in suppressing cellular transformation. PDF Chromatin: Interplay of PTEN with histone H1 p630 | doi:10.1038/nrm3883 PTEN maintains chromosome condensation by interacting with histone H1. PDF Cell migration: Putting pressure on the lead p631 | doi:10.1038/nrm3882 Lobopodial migration is driven by increased hydrostatic pressure in the cell anterior as a result of forward motion of the nucleus. PDF Cell signalling: Tyrosine kinases in extracellular space p632 | doi:10.1038/nrm3881 VLK is identified as the first extracellular Tyr kinase. It targets extracellular proteins and those in the secretory pathway. PDF Development: Honey, I shrunk the nucleus p633 | doi:10.1038/nrm3872 The size reduction of Xenopus laevis nuclei during development is controlled by increased nuclear localization and activity of conventional protein kinase C (cPKC). PDF JOURNAL CLUB The physiological relevance of death receptor-mediated apoptosis p633 | doi:10.1038/nrm3875 Andreas Strasser describes the first paper to outline a physiological role for apoptosis downstream of the death receptor FAS in lpr mice. PDF IN BRIEF Recombination: mRNAs repair double-strand breaks | Plant cell biology: SUMOylation mediates brassinosteroid effects | RNA metabolism: The fates of mRNAs in P bodies PDF Molecular Cell Biology JOBS of the week Asst / Assoc / Full Professor - Biology of Cancer - Department of Molecular Cell Biology University of California - Berkeley Postdoctoral Position in Molecular and Cell Biology University of Missouri Post-doctoral Research Fellow in Neural Stem Cell Biology Research Plymouth University Post Doctoral Fellow Istanbul University Institute of Experimental Medicine Group Leader - Developmental Biology European Molecular Biology Laboratory (EMBL) - Developmental Biology Unit More Science jobs from Molecular Cell Biology EVENT Plant Receptor Kinases: From Molecules to Environment 08.02.15 Taos, USA More science events from
REVIEWS		Top
Mitochondrial dynamics and inheritance during cell division, development and disease Prashant Mishra & David C. Chan p634 | doi:10.1038/nrm3877 Mitochondria contain a genome that is inherited maternally; this complicates their segregation during cell division, oogenesis and development. Mechanisms that ensure mitochondrial integrity include fusion and fission processes, organelle transport, mitophagy and genetic selection. Defects in these processes can lead to cell and tissue pathologies. Abstract | Full Text | PDF
Article series: Technologies and techniques Three-dimensional organotypic culture: experimental models of mammalian biology and disease Eliah R. Shamir & Andrew J. Ewald p647 | doi:10.1038/nrm3873 Recent advances in three-dimensional (3D) culture techniques have increased our understanding of the cellular mechanisms that drive epithelial tissue development, the genetic regulation of cell behaviours in epithelial tissues and the role of microenvironmental factors in normal development and disease. 3D culture can be used to build complex organs and to advance therapeutic approaches. Abstract | Full Text | PDF
Molecular mechanisms of de novo lumen formation Sara Sigurbjörnsdóttir, Renjith Mathew & Maria Leptin p665 | doi:10.1038/nrm3871 Recent studies suggest that mechanisms of de novo lumen formation in different systems — such as the zebrafish vasculature, C. elegans excretory cells, the D. melanogaster trachea and three-dimensional cultures of endothelial and MDCK cells — share some common features. They all involve expansion of the apical plasma membrane, vesicle transport and regulation of the microtubule and actin cytoskeletons. Abstract | Full Text | PDF
Capping protein regulators fine-tune actin assembly dynamics Marc Edwards et al. p677 | doi:10.1038/nrm3869 The actin capping activity of capping protein (CP) is indirectly regulated by competing with other factors for filament binding, or directly by factors that bind CP and sterically inhibit its interactions with filaments. Other proteins interact with CP through their 'capping protein interaction' (CPI) motif and modulate its activity via allosteric effects. Abstract | Full Text | PDF
PERSPECTIVES		Top
ESSAY Article series: Technologies and techniques A guide to the visual analysis and communication of biomolecular structural data Graham T. Johnson & Samuel Hertig p690 | doi:10.1038/nrm3874 To achieve effective visual communication of complex data, it is important that biologists identify the needs of their audience — whether they are peers or an outreach audience. This guide to the available wealth of resources, ranging from software tools to professional illustrators, should help researchers to generate better figures and presentations tailored to the needs of any audience. Abstract | Full Text | PDF | Supplementary information
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