Nature Reviews Microbiology contents October 2014 Volume 12 Number 10 pp 655-722

TABLE OF CONTENTS
October 2014 Volume 12 Number 10
Impact Factor 23.317 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article Series: Vector-borne diseases  Featured article: The gut microbiota, bacterial metabolites and colorectal cancer Petra Louis, Georgina L. Hold & Harry J. Flint
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RESEARCH HIGHLIGHTS Top Parasite physiology: Linking virulence and transmission in malaria p655 | doi:10.1038/nrmicro3354 Two studies identify two chromatin-associated proteins that regulate antigenic variation and sexual differentiation in Plasmodium falciparum. PDF Antimicrobials: Fungal fear of commitment p656 | doi:10.1038/nrmicro3348 A fungal pathogen evolves transient resistance to an antimicrobial drug using a novel RNAi-mediated pathway that generates reversible epimutations. PDF Bacterial pathogenesis: Unattractive S. Typhi p656 | doi:10.1038/nrmicro3350 Salmonella enterica subsp. enterica serovar Typhi escapes host defences by inhibiting complement activation and neutrophil chemotaxis. PDF DISEASE WATCH Ebola update p656 | doi:10.1038/nrmicro3355 PDF Host response: New LPS receptors discovered p658 | doi:10.1038/nrmicro3345 A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation. PDF Bacterial pathogenesis: In-house dining for phage p658 | doi:10.1038/nrmicro3359 Andrew Camilli and colleagues provide the first evidence that phage predation drives genomic diversification of V. cholerae in vivo. PDF IN BRIEF Bacterial transcription: Turning the switch on gene expression | Microbiome: Clostridia spp. combat food allergy in mice | Bacterial pathogenesis: Entry through a lipid zipper PDF Microbiology JOBS of the week Professor in Microbiology Univesity of Gothenburg Lecturer / Senior Lecturer (Infectious Disease / Medical Microbiology) University of New South Wales Assistant Professor in Microbiology (Applied Environmental Microbiology) University of Alaska Anchorage Lecturer in Environmental Microbiology University of Portsmouth Graduate student, PhD Clemson University More Science jobs from Microbiology EVENT Pharmaceutical Microbiology 21.01.15 London, UK More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Buzz off, that's my bee! Gemma Langridge p659 | doi:10.1038/nrmicro3353 This month's Genome Watch explores the interactions of bee bacterial symbionts with each other and with their apian hosts. PDF
REVIEWS		Top
The gut microbiota, bacterial metabolites and colorectal cancer Petra Louis, Georgina L. Hold & Harry J. Flint p661 | doi:10.1038/nrmicro3344 Accumulating evidence suggests that the gut microbiota has a role in the aetiology of colorectal cancer (CRC). In this Review, Flint and colleagues discuss the complex interplay between diet, the microbiota and microbial metabolites and argue that the combined metabolome of the microbiota has both protective and detrimental effects on inflammation and the progression of CRC. Abstract | Full Text | PDF
Article series: Vector-borne diseases Orthobunyaviruses: recent genetic and structural insights Richard M. Elliott p673 | doi:10.1038/nrmicro3332 Orthobunyaviruses are transmitted by arthropod vectors and can infect humans, animals and crops. In this Review, Elliott describes recent genetic and structural advances that have revealed important insights into the composition of orthobunyavirus virions, viral transcription and replication, and viral interactions with the host innate immune response. Abstract | Full Text | PDF
Master recyclers: features and functions of bacteria associated with phytoplankton blooms Alison Buchan, Gary R. LeCleir, Christopher A. Gulvik & José M. González p686 | doi:10.1038/nrmicro3326 Marine phytoplankton blooms are annual spring events that are accompanied by a surge in heterotrophic bacteria, primarily roseobacters, flavobacteria and members of the Gammaproteobacteria, which recycle most of the carbon that is fixed by the primary producers. In this Review, Buchan et al. describe the emerging physiological features and functions of these bacterial communities and their interactions with phytoplankton. Abstract | Full Text | PDF
Microbial oceanography and the Hawaii Ocean Time-series programme David M. Karl & Matthew J. Church p699 | doi:10.1038/nrmicro3333 The Hawaii Ocean Time-series programme recently completed 25 years of continuous operation. Matthew Church and David Karl look back on some of the major discoveries that have come from this long-term programme and its contribution to our evolving understanding of microbial oceanography. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Discovery of modulators of HIV-1 infection from the human peptidome Jan Münch, Ludger Ständker, Wolf-Georg Forssmann & Frank Kirchhoff p715 | doi:10.1038/nrmicro3312 Kirchhoff and colleagues discuss the discovery of novel antimicrobial peptides by systematic screening of complex peptide and protein libraries that have been derived from human bodily fluids and tissues, with a focus on the isolation of endogenous agents that affect HIV-1 infection. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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