Nature Reviews Genetics Contents October 2014 Volume 15 Number 10 pp 642-702

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TABLE OF CONTENTS
October 2014 Volume 15 Number 10		Advertisement
Impact Factor 39.794 *	In this issue Research Highlights Reviews Also this month Article series: Applications of next-generation sequencing  Featured article: Context-dependent control of alternative splicing by RNA-binding proteins Xiang-Dong Fu & Manuel Ares, Jr	Order one of the most comprehensive collections for quality control applications! Featuring over 100 applications, the Agilent 2100 Bioanalyzer application compendium describes a vast versatility of RNA, DNA and protein sample QC applications. The 2100 Bioanalyzer system offers unprecedented speed, flexibility, reproducibility and sensitivity.                 Request your compendium copy.
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RESEARCH HIGHLIGHTS Top Human evolution: Making the most of damage p642 | doi:10.1038/nrg3814 PDF Pathogen genetics: Temporary survival of the fittest? p642 | doi:10.1038/nrg3816 PDF Plant genetics: Passing the message — mRNA transfer between plants p643 | doi:10.1038/nrg3818 PDF Population genomics: A new window into the genetics of complex diseases p644 | doi:10.1038/nrg3815 PDF Gene regulation: Yin and Yang of Polycomb/Trithorax response elements p644 | doi:10.1038/nrg3817 PDF Signalling: An air of royalty p644 | doi:10.1038/nrg3820 PDF Pathogen genetics: Exploring gene function and parasite-host protein interactions p646 | doi:10.1038/nrg3819 PDF Technology: Testing all possibilities p646 | doi:10.1038/nrg3822 PDF IN BRIEF Pathogen genetics: Origin and transmission of Ebola virus outbreak | Non-coding RNA: Interrogating miRNA-target interactions in vivo | Population genomics: Determinants of genetic diversity | Signalling: Male exosomes affect female behaviour PDF Genetics JOBS of the week Genome Architecture / Function Biochemistry and Molecular Biology Department, Colorado State University Research Associate (Postdoctoral Position) Great Lakes Bioenergy Research Center (UW-Madison) Postdoctoral Researcher University of California - San Diego Postdoctoral Research Scientist in Genome Engineering Wellcome Trust Centre for Human Genetics Tenure Track Faculty Positions The Department of Genetics Washington University School of Medicine, St. Louis More Science jobs from Genetics EVENT Malaria Experimental Genetics 15.03.15 Bangkok, Thailand More science events from
REVIEWS		Top
Advances in the profiling of DNA modifications: cytosine methylation and beyond Nongluk Plongthongkum, Dinh H. Diep & Kun Zhang p647 | doi:10.1038/nrg3772 Recent developments and refinements to DNA methylation assays have led to the availability of several methods to detect and quantify cytosine modifications. This Review discusses the principles behind the newly developed techniques, compares the strengths and weaknesses of the different methods, and provides guidelines for selecting the most appropriate methods for particular experimental contexts. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Using next-generation sequencing to isolate mutant genes from forward genetic screens Korbinian Schneeberger p662 | doi:10.1038/nrg3745 Forward genetic screens have a long history of uncovering the genetic mutations underlying phenotypes of interest. This Review describes how next-generation sequencing technology can be integrated into forward genetic screens not only to enhance their efficiency but also to allow them to be carried out using expanded repertoires of species, populations and experimental strategies. Abstract | Full Text | PDF
Eusocial insects as emerging models for behavioural epigenetics Hua Yan, Daniel F. Simola, Roberto Bonasio, Jürgen Liebig, Shelley L. Berger & Danny Reinberg p677 | doi:10.1038/nrg3787 This Review provides insights into the use of eusocial insect species as models to study the role of epigenetic processes in regulating behaviour. Abstract | Full Text | PDF
Context-dependent control of alternative splicing by RNA-binding proteins Xiang-Dong Fu & Manuel Ares, Jr p689 | doi:10.1038/nrg3778 RNA-binding proteins (RBPs) influence alternative splicing in a highly context-sensitive and combinatorial manner, and it is therefore difficult to predict their actions on the basis of genomic sequence. However, recent progress in understanding alternative splicing, particularly using global approaches, has revealed new sets of rules for deciphering these patterns. This Review outlines the function of RBPs at different levels and describes the emerging rules of alternative splicing. Abstract | Full Text | PDF
Corrigendum: Identification and consequences of miRNA-target interactions — beyond repression of gene expression Jean Hausser & Mihaela Zavolan p702 | doi:10.1038/nrg3827 Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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