Nature Immunology Contents: October 2014 Volume 15 pp 895 - 996

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS October 2014 Volume 15, Issue 10 Commentary News and Views Research Highlights Review Articles Resource Retraction Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement   nature.com webcasts Macmillan Science Communication presents a custom webcast on: Understanding bacterial diversity through metagenomics 16S sequencing Wednesday September 24th, 2014  Time: 8AM PDT, 10AM CDT 11AM EDT, 4PM BST, 5PM CEST Register for the webcast and live Q and A session Sponsored by:     Commentary Top Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges   pp895 - 899 Peter Aaby, Tobias R Kollmann and Christine Stabell Benn doi:10.1038/ni.2961 Neonates represent a challenging group for vaccination. Effective vaccine programs will need to take into account a number of factors including gender and non-specific vaccine effects. News and Views Top Continued mission of ThPOK   pp900 - 902 Takeshi Egawa doi:10.1038/ni.2988 ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the transcription factor Runx3 in mature T cells. See also: Article by Vacchio et al. Neutrophils worm their way into macrophage long-term memory   pp902 - 904 John R Grainger and Richard K Grencis doi:10.1038/ni.2990 Neutrophil function is perhaps best studied in bacterial infection, during which they are directly involved in pathogen killing. After helminth invasion, however, neutrophils acquire an alternative transcriptional profile that allows them to 'train' macrophages to acquire long-term protective features. See also: Article by Chen et al. Bcl-6 gets T cells off the sugar   pp904 - 905 Kevin Man and Axel Kallies doi:10.1038/ni.2993 The transcriptional regulator Bcl-6 represses aerobic glycolysis in CD8+ and CD4+ type 1 helper T cells. See also: Article by Oestreich et al. High endothelial venules through a transcriptomics lens   pp906 - 908 Steven D Rosen and Richard Daneman doi:10.1038/ni.2994 Transcriptional profiling of endothelial cells from diverse secondary lymphoid organs reveals distinctions that underlie their functional specification. See also: Article by Zugasti et al. Immunology JOBS of the week Scientific Director, Global Medical Affairs CLL / Lymphoma Job Celgene Corporation Postdoctoral - Immunology Western New England University Postdoctoral Fellow in Immunology of Human Enteric Infections University of Utah Postdoc in mucosal immunology and microbiome University of Colorado Anschutz Medical Campus Post-doctoral Fellow - Arthritis and Clinical Immunology - (SKovats) Oklahoma Medical Research Foundation (OMRF) More Science jobs from Immunology EVENT IMMUNOLOGY 2015 AAI Annual Meeting 8th - 12th May 2015 New Orleans, USA More science events from Research Highlights Top Chronic infection double-whammy | ChIP to the next level | Receptor for new PAMPs | Antigen-presenting ILCs | Restricting plasma cells | Interferons in the brain Review Top Emerging functions of the unfolded protein response in immunity   pp910 - 919 Sophie Janssens, Bali Pulendran and Bart N Lambrecht doi:10.1038/ni.2991 The ER stress response is a well-characterized process aimed at restoring ER function. Lambrecht et al. explore how ER stress can also intersect with the innate and adaptive immune response at multiple levels. Articles Top Diversification of TAM receptor tyrosine kinase function   pp920 - 928 Anna Zagórska, Paqui G Través, Erin D Lew, Ian Dransfield and Greg Lemke doi:10.1038/ni.2986 The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice   pp929 - 937 Calum C Bain, Alberto Bravo-Blas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann et al. doi:10.1038/ni.2967 Many tissue-resident macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a bone marrow-derived macrophage population that requires continual replenishment. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion   pp938 - 946 Fei Chen, Wenhui Wu, Ariel Millman, Joshua F Craft, Eunice Chen et al. doi:10.1038/ni.2984 The role of neutrophils in helminth infection has been relatively unclear. Gause and colleagues demonstrate that neutrophils are involved in the priming of an M2 macrophage response that mediates long-term protection against helminth infection. A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells   pp947 - 956 Melanie S Vacchio, Lie Wang, Nicolas Bouladoux, Andrea C Carpenter, Yumei Xiong et al. doi:10.1038/ni.2960 The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Bosselut and colleagues show that ThPOK maintains CD4+ T lineage integrity and is required for proper TH1 and TH2 differentiation. See also: News and Views by Egawa Bcl-6 directly represses the gene program of the glycolysis pathway   pp957 - 964 Kenneth J Oestreich, Kaitlin A Read, Sarah E Gilbertson, Kenneth P Hough, Paul W McDonald et al. doi:10.1038/ni.2985 Cellular metabolism seems to dictate immune responses. Weinmann and colleagues show that the transcription factor Bcl-6 opposes the action of c-Myc and Hif-1α to suppress expression of genes encoding key glycolytic enzymes and transporters. See also: News and Views by Man & Kallies The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells   pp965 - 972 Alessio Lanna, Sian M Henson, David Escors and Arne N Akbar doi:10.1038/ni.2981 Senescent T cells have increased activity of the mitogen-activated protein kinase p38. Akbar and colleagues show that such cells lack the canonical and alternative p38-activation pathways and instead induce kinase AMPK-dependent autophosphorylation of p38. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells   pp973 - 981 Viviana Cremasco, Matthew C Woodruff, Lucas Onder, Jovana Cupovic, Janice M Nieves-Bonilla et al. doi:10.1038/ni.2965 Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in B cell zones, where they sustain B cell survival by providing BAFF. Resource Top Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing   pp982 - 995 Mike Lee, Helena Kiefel, Melissa D LaJevic, Matthew S Macauley, Edward O'Hara et al. doi:10.1038/ni.2983 High endothelial vessels (HEVs) provide the conduit for blood-borne leukocytes to enter lymph nodes. Butcher and colleagues report transcriptional profiles of various endothelial cell populations that can explain functional differences of homing-molecule modifications. See also: News and Views by Rosen & Daneman Retraction Top Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways   p996 Jiyeon S Kim, Tammarah Sklarz, Lauren B Banks, Mercy Gohil, Adam T Waickman et al. doi:10.1038/ni0910-996 Top Advertisement Nature Immunology Focus on TCR Signaling The development and effector function of T cells depends on signaling initiated via the T cell antigen receptor (TCR). Nature Immunology presents a Focus on TCR signaling with four specially commissioned Reviews.  Click here to access the Focus.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.