EMBO reports Table of Contents for September 2014; Vol. 15, No. 9

September 2014 | Volume 15, Number 9 Submit Table of Contents Editorial Hot off the Press Science & Society Review Scientific Reports Corrigendum Volume 15, Number 9 Editorial A piece of cake Databases are a vital tool for all molecular biologists. But entries are often hard to parse. We need more high‐level editorial input to make information accessible and reliable. Howy Jacobs Published online 03.09.2014 Hot off the Press p38 links RAS to GATA2 A study in this issue shows that oncogenic Ras increases GATA‐2 transcriptional activity by inducing p38‐mediated GATA‐2 phosphorylation, which provides a potential molecular explanation for the cooperative promotion of cancer development by Ras and GATA‐2. Christian Baumgartner and Manuela Baccarini Published online 03.08.2014 Science & Society Co‐author responsibility: Distinguishing between the moral and epistemic aspects of trust Should co‐authors be held responsible for research misconduct? A distinction between the moral and epistemic aspects of trust could help to distinguish between responsibility for poor science and responsibility for misconduct and improve current collaborative practices. Hanne Andersen Published online 11.08.2014 The most important application of science: As scientists have to justify research funding with potential social benefits, they may well add education to the list Science is increasingly expected to deliver economic benefits, sustainable development and human welfare. Embedding real science into education can address these expectations and the grand challenges facing humanity in the 21st century. Valentí Rull Published online 18.08.2014 Pulling teeth from history: DNA from ancient teeth can help to yield information about our ancestors' health, diet and diseases Teeth have proven to be an excellence source of ancient DNA. New analytical tools are helping to exploit this treasure trove to address questions about the link between diet and health, and the impact of historical epidemics with clear relevance for human health today. Philip Hunter Published online 22.08.2014 Review Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa Defects in left/right body asymmetry lead to severe pathologies in human. This review discusses divergent and common mechanisms of how and when symmetry is broken during embryogenesis in vertebrates and invertebrates, both at the cellular and organism level. Jean‐Baptiste Coutelis, Nicanor González‐Morales, Charles Géminard, and Stéphane Noselli Published online 22.08.2014 Scientific Reports Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA‐2 This study shows that p38α increases GATA‐2 activity at endogenous target genes by inducing GATA‐2 multi‐site phosphorylation. Oncogenic Ras is found to amplify this mechanism, which provides a potential molecular explanation for the cooperative promotion of cancer development by Ras and GATA‐2. Koichi R Katsumura, Chenxi Yang, Meghan E Boyer, Lingjun Li, and Emery H Bresnick Published online 23.07.2014 Sororin pre‐mRNA splicing is required for proper sister chromatid cohesion in human cells Sororin expression is shown to be critically sensitive to perturbations of the splicing machinery, which therefore result in defects in sister chromatid cohesion and genome instability. Erwan Watrin, Maria Demidova, Tanguy Watrin, Zheng Hu, and Claude Prigent Published online 04.08.2014 UBL5 is essential for pre‐mRNA splicing and sister chromatid cohesion in human cells The ubiquitin‐like protein UBL5 is shown to be required for pre‐mRNA splicing. Its absence leads to aberrant Sororin mRNA intron retention, low Sororin protein levels, and thus defective sister chromatid cohesion. Yasuyoshi Oka, Hanne Varmark, Kristoffer Vitting‐Seerup, Petra Beli, Johannes Waage, Anna Hakobyan, Martin Mistrik, Chunaram Choudhary, Mikkel Rohde, Simon Bekker‐Jensen, and Niels Mailand Published online 04.08.2014 Sumoylation controls host anti‐bacterial response to the gut invasive pathogen Shigella flexneri This study shows that the SUMO pathway is essential in the host response to Shigella invasion by regulating the interplay between intestinal permeability and transcriptional immune response. Sabrina Fritah, Nouara Lhocine, Filip Golebiowski, Joëlle Mounier, Alexandra Andrieux, Grégory Jouvion, Ronald T Hay, Philippe Sansonetti, and Anne Dejean Published online 05.08.2014 PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation The PI3P phosphatase MTM‐3 is required for autophagosome maturation and autolysosome formation in C. elegans, highlighting the importance of reducing PI3P levels at the autophagosomal membrane during these late steps of autophagy. Yanwei Wu, Shiya Cheng, Hongyu Zhao, Wei Zou, Sawako Yoshina, Shohei Mitani, Hong Zhang, and Xiaochen Wang Published online 14.08.2014 Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming Mitochondria are believed to have an important role in NLRP3 activation. Using 14 strains of knockout mice, this study finds no evidence for the involvement of mitochondrial damage in NLRP3 function, but shows that caspase‐8 is needed for inflammasome priming. Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi‐Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, and James E Vince Published online 02.07.2014 Regulatory T cells suppress CD4+ T cells through NFAT‐dependent transcriptional mechanisms Regulatory T cells are shown to induce the activation of NFAT1‐dependent gene expression in stimulated T‐helper cells, including the transcription of Ikaros, which is required for optimal T‐helper cell suppression in vitro and in vivo. Daniel S Shin, Ayana Jordan, Samik Basu, Rajan M Thomas, Sanmay Bandyopadhyay, Edwin F de Zoeten, Andrew D Wells, and Fernando Macian Published online 29.07.2014 Corrigendum AKT‐dependent phosphorylation of Niban regulates nucleophosmin‐ and MDM2‐mediated p53 stability and cell apoptosis Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing‐Hua Jiang, Gordon B Mills, and Zhimin Lu Published online 03.09.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.