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|  | | | |  | TABLE OF CONTENTS
| September 2014 Volume 46, Issue 9 |  | | |  |  Editorial
News and Views
Research Highlights
Commentary
Analysis
Articles
Letters
Corrigenda | | | | | |
Advertisement | | | The 2014 IMB Conference on Nuclear RNA in Gene Regulation & Chromatin Structure will focus on the emerging roles of RNA molecules in regulating gene expression and in affecting chromatin structure in the nucleus. The meeting aims on bringing together the latest concepts and findings in the field. Keynote speakers will be Ruth Lehmann and Steven E. Jacobsen. |  | | | | | | | Advertisement | | Frontiers Research Topics are collections of articles around a subject area at the cutting edge of knowledge and organized by leading researchers.
Gene interactions in pharmacogenomics
In recent years, research in pharmacogenomics has evolved from a candidate-gene approach to genome-wide association studies. This topic, hosted in the open-access journal Frontiers in Genetics, focuses on gene-gene and gene-environment interactions, and on interactions among pharmacogene regulatory elements. |  | | | | | | Editorial |  Top | |  | | Check but verify p927
doi:10.1038/ng.3088
Data sharing provides research with an essential opportunity for error correction by collaborators and disinterested parties alike. Public deposition ensures the useful formatting and recording of essential metadata. | | News and Views | Top | | | | | | Research Highlights | Top | | | | Pathogenic variants and secondary results | STING-mediated autoinflammatory disease | Loss-of-function variants in the Finnish population | NF-κβ signaling disrupted in neurodevelopmental disorders | Transcriptional cross-talk between tumor and stromal cells | Commentary | Top | | | | Data use under the NIH GWAS Data Sharing Policy and future directions OPEN pp934 - 938
Dina N Paltoo, Laura Lyman Rodriguez, Michael Feolo, Elizabeth Gillanders, Erin M Ramos, Joni L Rutter, Stephen Sherry, Vivian Ota Wang, Alice Bailey, Rebecca Baker, Mark Caulder, Emily L Harris, Kristofor Langlais, Hilary Leeds, Erin Luetkemeier, Taunton Paine, Tamar Roomian, Kimberly Tryka, Amy Patterson & Eric D Green for the National Institutes of Health Genomic Data Sharing Governance Committees
doi:10.1038/ng.3062
Dina Paltoo, Laura Lyman Rodriguez, Michael Feolo and colleagues present their analysis of the usefulness and impact of the first seven years of data sharing via the dbGaP repository and announce the extension of data-sharing provisions to other types of research funded by the NIH. | | Analysis | Top | | | | Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss pp939 - 943
Andrew M Gross, Ryan K Orosco, John P Shen, Ann Marie Egloff, Hannah Carter, Matan Hofree, Michel Choueiri, Charles S Coffey, Scott M Lippman, D Neil Hayes, Ezra E Cohen, Jennifer R Grandis, Quyen T Nguyen & Trey Ideker
doi:10.1038/ng.3051
Trey Ideker and colleagues report a comprehensive genome-wide analysis of head and neck squamous cell carcinoma, reporting that TP53 mutations are frequently accompanied by loss of chromosome 3p. Their data indicate that the combination of these two events has a stronger negative effect on survival rate than either event alone. | | Articles | Top | | | | A framework for the interpretation of de novo mutation in human disease pp944 - 950
Kaitlin E Samocha, Elise B Robinson, Stephan J Sanders, Christine Stevens, Aniko Sabo, Lauren M McGrath, Jack A Kosmicki, Karola Rehnström, Swapan Mallick, Andrew Kirby, Dennis P Wall, Daniel G MacArthur, Stacey B Gabriel, Mark DePristo, Shaun M Purcell, Aarno Palotie, Eric Boerwinkle, Joseph D Buxbaum, Edwin H Cook Jr, Richard A Gibbs, Gerard D Schellenberg, James S Sutcliffe, Bernie Devlin, Kathryn Roeder, Benjamin M Neale & Mark J Daly
doi:10.1038/ng.3050
Mark Daly and colleagues present a statistical framework to evaluate the role of de novo mutations in human disease by calibrating a model of de novo mutation rates at the individual gene level. The mutation probabilities defined by their model and list of constrained genes can be used to help identify genetic variants that have a significant role in disease. | | | | A genetic mechanism for Tibetan high-altitude adaptation pp951 - 956
Felipe R Lorenzo, Chad Huff, Mikko Myllymäki, Benjamin Olenchock, Sabina Swierczek, Tsewang Tashi, Victor Gordeuk, Tana Wuren, Ge Ri-Li, Donald A McClain, Tahsin M Khan, Parvaiz A Koul, Prasenjit Guchhait, Mohamed E Salama, Jinchuan Xing, Gregg L Semenza, Ella Liberzon, Andrew Wilson, Tatum S Simonson, Lynn B Jorde, William G Kaelin Jr, Peppi Koivunen & Josef T Prchal
doi:10.1038/ng.3067
Josef Prchal and colleagues identify a mutation in EGLN1 associated with adaptation to high altitude in Tibetan individuals. Their functional studies suggest a mechanism acting to reduce the erythropoietic response to hypoxia. | | | | Genome-wide association analyses identify variants in developmental genes associated with hypospadias pp957 - 963
Frank Geller, Bjarke Feenstra, Lisbeth Carstensen, Tune H Pers, Iris A L M van Rooij, Izabella Baranowska Körberg, Shweta Choudhry, Juha M Karjalainen, Tine H Schnack, Mads V Hollegaard, Wout F J Feitz, Nel Roeleveld, David M Hougaard, Joel N Hirschhorn, Lude Franke, Laurence S Baskin, Agneta Nordenskjöld, Loes F M van der Zanden & Mads Melbye
doi:10.1038/ng.3063
Frank Geller and colleagues report the results of a large genome-wide association study of hypospadias. They identify 18 susceptibility regions for this common congenital condition, many of which harbor genes important for embryonic development. | | | | Human somatic cell mutagenesis creates genetically tractable sarcomas pp964 - 972
Sam D Molyneux, Paul D Waterhouse, Dawne Shelton, Yang W Shao, Christopher M Watling, Qing-Lian Tang, Isaac S Harris, Brendan C Dickson, Pirashaanthy Tharmapalan, Geir K Sandve, Xiaoyang Zhang, Swneke D Bailey, Hal Berman, Jay S Wunder, Zsuzsanna Iszvak, Mathieu Lupien, Tak W Mak & Rama Khokha
doi:10.1038/ng.3065
Rama Khokha and colleagues report a new mutagenesis method, called Lentihop, for creating spontaneous, genetically tractable tumors from normal human cells. Through genetic analysis of Lentihop-derived tumors, they find known drivers of sarcomas and identify new candidate tumor suppressor genes, including HDLBP and ADARB2.
See also: News and Views by van der Weyden et al. | | | | A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element pp973 - 981
Veronika A Herzog, Adelheid Lempradl, Johanna Trupke, Helena Okulski, Christina Altmutter, Frank Ruge, Bernd Boidol, Stefan Kubicek, Gerald Schmauss, Karin Aumayr, Marius Ruf, Andrew Pospisilik, Andrew Dimond, Hasene Basak Senergin, Marcus L Vargas, Jeffrey A Simon & Leonie Ringrose
doi:10.1038/ng.3058
Leonie Ringrose and colleagues show that a switch between forward and reverse noncoding transcription at the Drosophila melanogaster vestigial Polycomb/Trithorax response element switches the status of the element between silencing and activation. They further show that strand switching of noncoding RNAs occurs at several hundred PcG-binding sites in flies and vertebrates, suggesting that this regulatory mechanism could be widespread.
See also: News and Views by Quinn & Chang | | | | The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication OPEN pp982 - 988
Muhua Wang, Yeisoo Yu, Georg Haberer, Pradeep Reddy Marri, Chuanzhu Fan, Jose Luis Goicoechea, Andrea Zuccolo, Xiang Song, Dave Kudrna, Jetty S S Ammiraju, Rosa Maria Cossu, Carlos Maldonado, Jinfeng Chen, Seunghee Lee, Nick Sisneros, Kristi de Baynast, Wolfgang Golser, Marina Wissotski, Woojin Kim, Paul Sanchez, Marie-Noelle Ndjiondjop, Kayode Sanni, Manyuan Long, Judith Carney, Olivier Panaud, Thomas Wicker, Carlos A Machado, Mingsheng Chen, Klaus F X Mayer, Steve Rounsley & Rod A Wing
doi:10.1038/ng.3044
Mingsheng Chen, Klaus Mayer, Steve Rounsley, Rod Wing and colleagues report the genome sequence of African rice (Oryza glaberrima), a different species than Asian rice. The authors resequenced 20 O. glaberrima accessions and 94 Oryza barthii accessions (the putative progenitor species of O. glaberrima), and their analyses support the hypothesis that O. glaberrima was domesticated in a single region along the upper Niger river.
See also: News and Views by Purugganan | | Letters | Top | | | | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease pp989 - 993
Mike A Nalls, Nathan Pankratz, Christina M Lill, Chuong B Do, Dena G Hernandez, Mohamad Saad, Anita L DeStefano, Eleanna Kara, Jose Bras, Manu Sharma, Claudia Schulte, Margaux F Keller, Sampath Arepalli, Christopher Letson, Connor Edsall, Hreinn Stefansson, Xinmin Liu, Hannah Pliner, Joseph H Lee, Rong Cheng, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), The Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, M Arfan Ikram, John P A Ioannidis, Georgios M Hadjigeorgiou, Joshua C Bis, Maria Martinez, Joel S Perlmutter, Alison Goate, Karen Marder, Brian Fiske, Margaret Sutherland, Georgia Xiromerisiou, Richard H Myers, Lorraine N Clark, Kari Stefansson, John A Hardy, Peter Heutink, Honglei Chen, Nicholas W Wood, Henry Houlden, Haydeh Payami, Alexis Brice, William K Scott, Thomas Gasser, Lars Bertram, Nicholas Eriksson, Tatiana Foroud & Andrew B Singleton
doi:10.1038/ng.3043
Andrew Singleton and colleagues report a large-scale meta-analysis of genome-wide association data in Parkinson's disease using over 13,000 cases and 95,000 controls plus additional samples for replication. They identify 6 new risk loci and replicate 28 independent risk variants for Parkinson's disease across 24 loci. | | | | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer pp994 - 1000
Brian M Wolpin, Cosmeri Rizzato, Peter Kraft, Charles Kooperberg, Gloria M Petersen, Zhaoming Wang, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Julie Buring, Federico Canzian, Eric J Duell, Steven Gallinger, Graham G Giles, Gary E Goodman, Phyllis J Goodman, Eric J Jacobs, Aruna Kamineni, Alison P Klein, Laurence N Kolonel, Matthew H Kulke, Donghui Li, Núria Malats, Sara H Olson, Harvey A Risch, Howard D Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C Abnet, Demetrius Albanes, Gabriella Andreotti, Melissa A Austin, Richard Barfield, Daniela Basso, Sonja I Berndt, Marie-Christine Boutron-Ruault, Michelle Brotzman, Markus W Büchler, H Bas Bueno-de-Mesquita, Peter Bugert, Laurie Burdette, Daniele Campa, Neil E Caporaso, Gabriele Capurso, Charles Chung, Michelle Cotterchio, Eithne Costello, Joanne Elena, Niccola Funel, J Michael Gaziano, Nathalia A Giese, Edward L Giovannucci, Michael Goggins, Megan J Gorman, Myron Gross, Christopher A Haiman, Manal Hassan, Kathy J Helzlsouer, Brian E Henderson, Elizabeth A Holly, Nan Hu, David J Hunter, Federico Innocenti, Mazda Jenab, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C Kurtz, Andrea LaCroix, Maria T Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L Milne, Yusuke Nakamura, Ann L Oberg, Kouros Owzar, Alpa V Patel, Petra H M Peeters, Ulrike Peters, Raffaele Pezzilli, Ada Piepoli, Miquel Porta, Francisco X Real, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Xiao-Ou Shu, Debra T Silverman, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Philip R Taylor, George E Theodoropoulos, Mark Thornquist, Anne Tjønneland, Geoffrey S Tobias, Dimitrios Trichopoulos, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Chen Wu, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Robert Hoover, Patricia Hartge, Charles Fuchs, Stephen J Chanock, Rachael S Stolzenberg-Solomon & Laufey T Amundadottir
doi:10.1038/ng.3052
Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci. | | | | Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations pp1001 - 1006
Chen Wu, Zhaoming Wang, Xin Song, Xiao-Shan Feng, Christian C Abnet, Jie He, Nan Hu, Xian-Bo Zuo, Wen Tan, Qimin Zhan, Zhibin Hu, Zhonghu He, Weihua Jia, Yifeng Zhou, Kai Yu, Xiao-Ou Shu, Jian-Min Yuan, Wei Zheng, Xue-Ke Zhao, She-Gan Gao, Zhi-Qing Yuan, Fu-You Zhou, Zong-Min Fan, Ji-Li Cui, Hong-Li Lin, Xue-Na Han, Bei Li, Xi Chen, Sanford M Dawsey, Linda Liao, Maxwell P Lee, Ti Ding, You-Lin Qiao, Zhihua Liu, Yu Liu, Dianke Yu, Jiang Chang, Lixuan Wei, Yu-Tang Gao, Woon-Puay Koh, Yong-Bing Xiang, Ze-Zhong Tang, Jin-Hu Fan, Jing-Jing Han, Sheng-Li Zhou, Peng Zhang, Dong-Yun Zhang, Yuan Yuan, Ying Huang, Chunling Liu, Kan Zhai, Yan Qiao, Guangfu Jin, Chuanhai Guo, Jianhua Fu, Xiaoping Miao, Changdong Lu, Haijun Yang, Chaoyu Wang, William A Wheeler, Mitchell Gail, Meredith Yeager, Jeff Yuenger, Er-Tao Guo, Ai-Li Li, Wei Zhang, Xue-Min Li, Liang-Dan Sun, Bao-Gen Ma, Yan Li, Sa Tang, Xiu-Qing Peng, Jing Liu, Amy Hutchinson, Kevin Jacobs, Carol Giffen, Laurie Burdette, Joseph F Fraumeni Jr, Hongbing Shen, Yang Ke, Yixin Zeng, Tangchun Wu, Peter Kraft, Charles C Chung, Margaret A Tucker, Zhi-Chao Hou, Ya-Li Liu, Yan-Long Hu, Yu Liu, Li Wang, Guo Yuan, Li-Sha Chen, Xiao Liu, Teng Ma, Hui Meng, Li Sun, Xin-Min Li, Xiu-Min Li, Jian-Wei Ku, Ying-Fa Zhou, Liu-Qin Yang, Zhou Wang, Yin Li, Qirenwang Qige, Wen-Jun Yang, Guang-Yan Lei, Long-Qi Chen, En-Min Li, Ling Yuan, Wen-Bin Yue, Ran Wang, Lu-Wen Wang, Xue-Ping Fan, Fang-Heng Zhu, Wei-Xing Zhao, Yi-Min Mao, Mei Zhang, Guo-Lan Xing, Ji-Lin Li, Min Han, Jing-Li Ren, Bin Liu, Shu-Wei Ren, Qing-Peng Kong, Feng Li, Ilyar Sheyhidin, Wu Wei, Yan-Rui Zhang, Chang-Wei Feng, Jin Wang, Yu-Hua Yang, Hong-Zhang Hao, Qi-De Bao, Bao-Chi Liu, Ai-Qun Wu, Dong Xie, Wan-Cai Yang, Liang Wang, Xiao-Hang Zhao, Shu-Qing Chen, Jun-Yan Hong, Xue-Jun Zhang, Neal D Freedman, Alisa M Goldstein, Dongxin Lin, Philip R Taylor, Li-Dong Wang & Stephen J Chanock
doi:10.1038/ng.3064
Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci. | | | | Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3 pp1007 - 1011
Shengping Hou, Liping Du, Bo Lei, Chi Pui Pang, Meifen Zhang, Wenjuan Zhuang, Minglian Zhang, Lulin Huang, Bo Gong, Meilin Wang, Qi Zhang, Ke Hu, Qingyun Zhou, Jian Qi, Chaokui Wang, Yuan Tian, Zi Ye, Liang Liang, Hongsong Yu, Hong Li, Yan Zhou, Qingfeng Cao, Yunjia Liu, Lin Bai, Dan Liao, Aize Kijlstra, Jianfeng Xu, Zhenglin Yang & Peizeng Yang
doi:10.1038/ng.3061
Peizeng Yang, Zhenglin Yang and colleagues report results of a genome-wide association study of Vogt-Koyanagi-Harada syndrome. They confirm strong association with the HLA region and identify two new susceptibility loci, including variants near IL23R. | | | | A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine pp1012 - 1016
Masahiro Nakajima, Atsushi Takahashi, Takashi Tsuji, Tatsuki Karasugi, Hisatoshi Baba, Kenzo Uchida, Shigenori Kawabata, Atsushi Okawa, Shigeo Shindo, Kazuhiro Takeuchi, Yuki Taniguchi, Shingo Maeda, Masafumi Kashii, Atsushi Seichi, Hideaki Nakajima, Yoshiharu Kawaguchi, Shunsuke Fujibayashi, Masahiko Takahata, Toshihiro Tanaka, Kei Watanabe, Kazunobu Kida, Tsukasa Kanchiku, Zenya Ito, Kanji Mori, Takashi Kaito, Sho Kobayashi, Kei Yamada, Masahito Takahashi, Kazuhiro Chiba, Morio Matsumoto, Ken-Ichi Furukawa, Michiaki Kubo, Yoshiaki Toyama, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments & Shiro Ikegawa
doi:10.1038/ng.3045
Shiro Ikegawa and colleagues report the results of a genome-wide association study for ossification of the posterior longitudinal ligament of the spine in a Japanese cohort. They identify six new loci, three of which showed decreased expression in a mouse model of endochondral ossification. | | | | A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia pp1017 - 1020
Suk-Kyun Yang, Myunghee Hong, Jiwon Baek, Hyunchul Choi, Wanting Zhao, Yusun Jung, Talin Haritunians, Byong Duk Ye, Kyung-Jo Kim, Sang Hyoung Park, Soo-Kyung Park, Dong-Hoon Yang, Marla Dubinsky, Inchul Lee, Dermot P B McGovern, Jianjun Liu & Kyuyoung Song
doi:10.1038/ng.3060
Kyuyoung Song and colleagues report the results of a two-stage association study of thiopurine-induced early leukopenia in individuals undergoing treatment for Crohn's disease. They find a missense variant in NUDT15 associated with substantially higher risk of developing this life-threatening complication to thiopurine therapy. | | | | JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia pp1021 - 1027
Kaan Boztug, Päivi M Järvinen, Elisabeth Salzer, Tomas Racek, Sebastian Mönch, Wojciech Garncarz, E Michael Gertz, Alejandro A Schäffer, Aristotelis Antonopoulos, Stuart M Haslam, Lena Schieck, Jacek Puchałka, Jana Diestelhorst, Giridharan Appaswamy, Brigitte Lescoeur, Roberto Giambruno, Johannes W Bigenzahn, Ulrich Elling, Dietmar Pfeifer, Cecilia Domínguez Conde, Michael H Albert, Karl Welte, Gudrun Brandes, Roya Sherkat, Jutte van der Werff ten Bosch, Nima Rezaei, Amos Etzioni, Christine Bellanné-Chantelot, Giulio Superti-Furga, Josef M Penninger, Keiryn L Bennett, Julia von Blume, Anne Dell, Jean Donadieu & Christoph Klein
doi:10.1038/ng.3069
Christoph Klein and colleagues identify homozygous mutations in the JAGN1 gene in families and individuals with severe congenital neutropenia. They show that JAGN1 is necessary for the differentiation and survival of neutrophil granulocytes. | | | | Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense pp1028 - 1033
Gerald Wirnsberger, Florian Zwolanek, Johannes Stadlmann, Luigi Tortola, Shang Wan Liu, Thomas Perlot, Päivi Järvinen, Gerhard Dürnberger, Ivona Kozieradzki, Renu Sarao, Alba De Martino, Kaan Boztug, Karl Mechtler, Karl Kuchler, Christoph Klein, Ulrich Elling & Josef M Penninger
doi:10.1038/ng.3070
Josef Penninger and colleagues generate mice with conditional knockout of Jagn1 in hematopoietic cells. They show that the mice have a defective neutrophil-mediated immune response to Candida albicans, and GM-CSF treatment restored the defective fungicidal activity. | | | | The genome of the stress-tolerant wild tomato species Solanum pennellii OPEN pp1034 - 1038
Anthony Bolger, Federico Scossa, Marie E Bolger, Christa Lanz, Florian Maumus, Takayuki Tohge, Hadi Quesneville, Saleh Alseekh, Iben Sørensen, Gabriel Lichtenstein, Eric A Fich, Mariana Conte, Heike Keller, Korbinian Schneeberger, Rainer Schwacke, Itai Ofner, Julia Vrebalov, Yimin Xu, Sonia Osorio, Saulo Alves Aflitos, Elio Schijlen, José M Jiménez-Goméz, Malgorzata Ryngajllo, Seisuke Kimura, Ravi Kumar, Daniel Koenig, Lauren R Headland, Julin N Maloof, Neelima Sinha, Roeland C H J van Ham, René Klein Lankhorst, Linyong Mao, Alexander Vogel, Borjana Arsova, Ralph Panstruga, Zhangjun Fei, Jocelyn K C Rose, Dani Zamir, Fernando Carrari, James J Giovannoni, Detlef Weigel, Björn Usadel & Alisdair R Fernie
doi:10.1038/ng.3046
Björn Usadel and colleagues report the genome sequence of the wild tomato species Solanum pennellii. The authors identify genes important for stress tolerance, metabolism and fruit maturation and suggest that transposable elements have had an important role in the evolution of the S. penellii stress response. | | Corrigenda | Top | | | | Corrigendum: Genome-wide genetic changes during modern breeding of maize pp1039 - 1040
Yinping Jiao, Hainan Zhao, Longhui Ren, Weibin Song, Biao Zeng, Jinjie Guo, Baobao Wang, Zhipeng Liu, Jing Chen, Wei Li, Mei Zhang, Shaojun Xie & Jingsheng Lai
doi:10.1038/ng0914-1039 | |  | | Corrigendum: A copy number variation morbidity map of developmental delay p1040
Gregory M Cooper, Bradley P Coe, Santhosh Girirajan, Jill A Rosenfeld, Tiffany H Vu, Carl Baker, Charles Williams, Heather Stalker, Rizwan Hamid, Vickie Hannig, Hoda Abdel-Hamid, Patricia Bader, Elizabeth McCracken, Dmitriy Niyazov, Kathleen Leppig, Heidi Thiese, Marybeth Hummel, Nora Alexander, Jerome Gorski, Jennifer Kussmann, Vandana Shashi, Krys Johnson, Catherine Rehder, Blake C Ballif, Lisa G Shaffer & Evan E Eichler
doi:10.1038/ng0914-1040a | | | | Corrigendum: Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions pp1040 - 1041
Chen Wu, Peter Kraft, Kan Zhai, Jiang Chang, Zhaoming Wang, Yun Li, Zhibin Hu, Zhonghu He, Weihua Jia, Christian C Abnet, Liming Liang, Nan Hu, Xiaoping Miao, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Yan Qiao, Yuling Zhou, Guangfu Jin, Chuanhai Guo, Changdong Lu, Haijun Yang, Jianhua Fu, Dianke Yu, Neal D Freedman, Ti Ding, Wen Tan, Alisa M Goldstein, Tangchun Wu, Hongbing Shen, Yang Ke, Yixin Zeng, Stephen J Chanock, Philip R Taylor & Dongxin Lin
doi:10.1038/ng0914-1040b | | | | Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54 p1041
Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, Xin Song, Yan Jin, Jiang-Man Li, Guo-Qiang Kong, Hong Qi, Juan Cui, Lian-Qun Zhang, Jie-Zhi Yang, Ji-Lin Li, Xing-Chuan Li, Jing-Li Ren, Zhi-Cai Liu, Wen-Jun Gao, Ling Yuan, Wu Wei, Yan-Rui Zhang, Wei-Peng Wang, Ilyar Sheyhidin, Feng Li, Bao-Ping Chen, Shu-Wei Ren, Bin Liu, Dan Li, Jian-Wei Ku, Zong-Min Fan, Sheng-Li Zhou, Zhi-Gang Guo, Xue-Ke Zhao, Na Liu, Yong-Hong Ai, Fang-Fang Shen, Wen-Yan Cui, Shuang Song, Tao Guo, Jing Huang, Chao Yuan, Jia Huang, Yue Wu, Wen-Bin Yue, Chang-Wei Feng, Hong-Lei Li, Yan Wang, Jin-Ya Tian, Yue Lu, Yi Yuan, Wen-Liang Zhu, Min Liu, Wen-Jing Fu, Xia Yang, Han-Jing Wang, Suo-Li Han, Jie Chen, Min Han, Hai-Yan Wang, Peng Zhang, Xiu-Min Li, Jin-Cheng Dong, Guo-Lan Xing, Ran Wang, Ming Guo, Zhi-Wei Chang, Hai-Lin Liu, Li Guo, Zhi-Qing Yuan, Hai Liu, Qin Lu, Liu-Qin Yang, Fu-Guo Zhu, Xiu-Feng Yang, Xiao-Shan Feng, Zhou Wang, Yin Li, She-Gan Gao, Qirenwang Qige, Long-Tang Bai, Wen-Jun Yang, Guang-Yan Lei, Zhong-Ying Shen, Long-Qi Chen, En-Min Li, Li-Yan Xu, Zhi-Yong Wu, Wei-Ke Cao, Jian-Po Wang, Zhi-Qin Bao, Ji-Li Chen, Guang-Cheng Ding, Xiang Zhuang, Ying-Fa Zhou, Hou-Feng Zheng, Zheng Zhang, Xian-Bo Zuo, Zi-Ming Dong, Dong-Mei Fan, Xin He, Jin Wang, Qi Zhou, Qin-Xian Zhang, Xin-Ying Jiao, Shi-Yong Lian, Ai-Fang Ji, Xiao-Mei Lu, Jin-Sheng Wang, Fu-Bao Chang, Chang-Dong Lu, Zhi-Guo Chen, Jian-Jun Miao, Zeng-Lin Fan, Ruo-Bai Lin, Tai-Jiang Liu, Jin-Chang Wei, Qing-Peng Kong, Yu Lan, Yu-Jing Fan, Fu-Sheng Gao, Tian-Yun Wang, Dong Xie, Shu-Qing Chen, Wan-Cai Yang, Jun-Yan Hong, Liang Wang, Song-Liang Qiu, Zhi-Ming Cai & Xue-Jun Zhang
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