Nature Reviews Immunology Contents August 2014 Volume 14 Number 8 pp 515-578

TABLE OF CONTENTS
August 2014 Volume 14 Number 8
Impact Factor 33.129 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Developmental gene networks: a triathlon on the course to T cell identity Mary A. Yui & Ellen V. Rothenberg
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RESEARCH HIGHLIGHTS Top Inflammasomes: Acting out p515 | doi:10.1038/nri3717 NLRP3 inflammasomes can act extracellularly and thereby amplify the inflammatory response. PDF Innate immunity: Peroxisomes pack a distinct punch p516 | doi:10.1038/nri3718 Intracellular infection induces type III interferon production from peroxisomes. PDF Cytokines: Tipping TB off balance p516 | doi:10.1038/nri3722 Interleukin-1 confers resistance to tuberculosis through the induction of eicosanoids that antagonize type I interferons. PDF Memory responses: Fitter, faster, better innate immune cells p517 | doi:10.1038/nri3716 Interferon-γ production by memory T cells drives faster and more effective innate immune cell responses. PDF T cell memory: Metabolic self-reliance p518 | doi:10.1038/nri3721 Memory T cells synthesize the substrates for metabolic reprogramming to fatty acid oxidation in a cell-intrinsic manner. PDF T cell recognition: A hidden heavy metal p518 | doi:10.1038/nri3724 CD4+ T cells detect beryllium hidden within peptide–MHC class II complexes. PDF Mucosal immunology: Two routes to success p519 | doi:10.1038/nri3723 Porphyromonas gingivalis evades immune-mediated killing and promotes inflammation to ensure its survival and drive dysbiosis. PDF Microbiology JOBS of the week Postdoctoral Fellow in Immunology Johns Hopkins University Postdoctoral fellow-Transplantation Immunology Katip Celebi University&Tepecik Education and Research Hospital Associate Investigator Baylor Institute for Immunology Research NIH T32 Postdoctoral Fellowship-Molecular and Tumor Immunology Moffitt Cancer Center & Research Institute Post-doctoral position in molecular Immunology Baylor Research Institute More Science jobs from Microbiology EVENT Conference on Cell and Gene Therapy for HIV Cure 2014 26.08.14 Seattle, USA More science events from
PROGRESS		Top
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Veit Hornung, Rune Hartmann, Andrea Ablasser & Karl-Peter Hopfner p521 | doi:10.1038/nri3719 The presence of nucleic acids in the cytosol alerts the cell to viral infection or damaged self. The oligoadenylate synthase (OAS) proteins and cyclic GMP–AMP synthase (cGAS) are enzymes that detect this danger and promote antiviral immunity. Recent structural studies reveal that these enzymes have a common mechanism of action and probably the same evolutionary origin. Abstract | Full Text | PDF
REVIEWS		Top
Developmental gene networks: a triathlon on the course to T cell identity Mary A. Yui & Ellen V. Rothenberg p529 | doi:10.1038/nri3702 T cell development can be divided into three major regulatory phases by the checkpoints that occur at commitment to the T cell lineage and at β-selection. The three phases are each governed by different gene networks that confer distinct cellular characteristics. The correct developmental programme depends on the sequential operation of these gene networks, and cells that fail to enforce the boundaries between phases may be predisposed to leukaemic transformation. Abstract | Full Text | PDF | Supplementary information
Assembly and localization of Toll-like receptor signalling complexes Nicholas J. Gay, Martyn F. Symmons, Monique Gangloff & Clare E. Bryant p546 | doi:10.1038/nri3713 In this Review, the authors describe how Toll-like receptors (TLRs) assemble with signalling adaptor proteins to form higher-order scaffolds that signal in response to pathogen sensing. Productive TLR signalling involves cooperative assembly, post-translational modification and subcellular localization of the components of the signalling complexes. Abstract | Full Text | PDF | Supplementary information
Immune modulation by butyrophilins Heather A. Arnett & Joanne L. Viney p559 | doi:10.1038/nri3715 The butyrophilins are members of the immunoglobulin superfamily that have previously been poorly understood, however they are now emerging as key modulators of the immune system. Here, the authors describe the diverse ways in which butyrophilins can modify immune cell activity and discuss the potential of targeting this family for therapeutic purposes. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny Martin Guilliams, Florent Ginhoux, Claudia Jakubzick, Shalin H. Naik, Nobuyuki Onai, Barbara U. Schraml, Elodie Segura, Roxane Tussiwand & Simon Yona p571 | doi:10.1038/nri3712 Cells of the mononuclear phagocyte system (MPS) are usually defined by particular functional or phenotypical characteristics. However, this has led to confusion in the field, as many of the criteria that are used to define a particular cell population may actually be shared with other cell types. In this Opinion article, the authors propose that a new nomenclature that is based on cell ontogeny could enable a more robust classification of MPS cells. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Consortium biology in immunology: the perspective from the Immunological Genome Project Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis & The Immunological Genome Project p578 | doi:10.1038/nri3714 Full Text | PDF
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