Scientific Reports Biology Table of Contents e-alert: 24 June 2014

If you are unable to see the message below, click here to view.

24 June 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Differential responses to thermal variation between fitness metrics ▶     Sabrina Clavijo-Baquet, Francisca Boher, Lucia Ziegler et al.     Temperature is a major factor affecting population abundance and individual performance. Net reproductive rate (R0) and intrinsic rate of increase (r) differ in their response to …             Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma ▶     Bingli Wu, Chunquan Li, Zepeng Du et al.     LCN2 (lipocalin 2) is a member of the lipocalin family of proteins that transport small, hydrophobic ligands. LCN2 is elevated in various cancers including esophageal squamous …             Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells ▶     Yilan Zhang, Xianglian Ge, Fayu Yang et al.     CRISPR/Cas9 -mediated DNA cleavage (CCMDC) is becoming increasingly used for efficient genome engineering. Proto-spacer adjacent motif (PAM) adjacent to target sequence is one of …             3′UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network ▶     Li Li, Duolin Wang, Mengzhu Xue et al.     Competing endogenous RNA (ceRNA) interactions form a multilayered network that regulates gene expression in various biological pathways. Recent studies have demonstrated novel …             Differential requirement of GRP94 and GRP78 in mammary gland development ▶     Genyuan Zhu, Miao Wang, Benjamin Spike et al.     Glucose Regulated Protein (GRP) 94 and GRP78 are critical molecular chaperones and regulators of signaling. Conditional knockout mouse models have revealed tissue specific …             Green strategy from waste to value-added-chemical production: efficient biosynthesis of 6-hydroxy-3-succinoyl-pyridine by an engineered biocatalyst ▶     Hao Yu, Hongzhi Tang, Ping Xu     Value-added intermediates produced by microorganisms during the catabolism of N-heterocycles are potential building blocks for agrochemical synthesis and pharmaceutical …             Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system ▶     Tetsushi Sakuma, Ayami Nishikawa, Satoshi Kume et al.     CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications, not only for single gene targeting, but also for multiple targeted mutagenesis. To …             Professional diversity and the productivity of cities ▶     Luís M. A. Bettencourt, Horacio Samaniego, Hyejin Youn     Attempts to understand the relationship between diversity, productivity and scale have remained limited due to the scheme-dependent nature of the taxonomies describing complex …             Three-dimensional super-resolution and localization of dense clusters of single molecules ▶     Anthony Barsic, Ginni Grover, Rafael Piestun     When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes …             Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems ▶     Takashi Nakano, Catherine Chin, David Mo Aung Myint et al.     Existing nanoscale chemical delivery systems target diseased cells over long, sustained periods of time, typically through one-time, destructive triggering. Future directions lie …             Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique ▶     Wanjuan Chen, Jingxin Liu, Longmei Zhang et al.     Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement …             Rational design and validation of a Tip60 histone acetyltransferase inhibitor ▶     Chunxia Gao, Emer Bourke, Martin Scobie et al.     Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including …             Tyrosinase-catalyzed site-specific immobilization of engineered C-phycocyanin to surface ▶     Greta Faccio, Michael M. Kämpf, Chiara Piatti et al.     Enzymatic crosslinking of proteins is often limited by the steric availability of the target residues, as of tyrosyl side chains in the case of tyrosinase. Carrying an N-terminal …             Visual tracking combined with hand-tracking improves time perception of moving stimuli ▶     Alessandro Carlini, Robert French     A number of studies have shown that performing a secondary task while executing a time-judgment task impairs performance on the latter task. However, this turns out not to be the …             Epigenetic Regulation by Chromatin Activation Mark H3K4me3 in Primate Progenitor Cells within Adult Neurogenic Niche ▶     Richard S. Sandstrom, Michael R. Foret, Douglas A. Grow et al.     Histone 3 lysine 4 trimethylation (H3K4me3) is known to be associated with transcriptionally active or poised genes and required for postnatal neurogenesis within the …             Analysis of phytoplasma-responsive sRNAs provide insight into the pathogenic mechanisms of mulberry yellow dwarf disease ▶     Ying-Ping Gai, Yi-Qun Li, Fang-Yue Guo et al.     The yellow dwarf disease associated with phytoplasmas is one of the most devastating diseases of mulberry and the pathogenesis involved in the disease is poorly understood. To …             Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions ▶     Stefania Corvaglia, Barbara Sanavio, Rolando P. Hong Enriquez et al.     Intrinsically Disordered Proteins (IDPs) are characterized by the lack of well-defined 3-D structure and show high conformational plasticity. For this reason, they are a strong …             Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells ▶     Yan Zhou, Kai Sun, Yi Ma et al.     The tumor microenvironment, including ischemia, has been increasingly recognized as a critical factor in the process of tumor development. Hypoxia and nutrient deficiency …             Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma ▶     Changsong Wang, Bo Sun, Lei Guo et al.     The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic …             Quantifying the impact of exogenous abscisic acid and gibberellins on pre-maturity α-amylase formation in developing wheat grains ▶     Kirtikumar R. Kondhare, Peter Hedden, Peter S. Kettlewell et al.     To study the role of abscisic acid (ABA) and gibberellins (GA) in pre-maturity α-amylase (PMA) formation in developing wheat grain, two glasshouse experiments were conducted under …             Light-induced rapid Ca2+ response and MAPK phosphorylation in the cells heterologously expressing human OPN5 ▶     Takashi Sugiyama, Hirobumi Suzuki, Takeo Takahashi     Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here …             Luminescent threat: toxicity of light stick attractors used in pelagic fishery ▶     Tiago Franco de Oliveira, Amanda Lucila Medeiros da Silva, Rafaela Alves de Moura et al.     Light sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an …             Brain signatures of moral sensitivity in adolescents with early social deprivation ▶     María Josefina Escobar, David Huepe, Jean Decety et al.     The present study examined neural responses associated with moral sensitivity in adolescents with a background of early social deprivation. Using high-density …             Survey of the Japanese Coast Reveals Abundant Placozoan Populations in the Northern Pacific Ocean ▶     Hiroaki Nakano     Placozoans are the simplest extant free-living animals consisting of only five cell types and lacking neurons and muscle cells. Their phylogenetic position implies they are …             Analysis of interactions between SNARE proteins using imaging ellipsometer coupled with microfluidic array ▶     Cai Qi, Hong Zhang, Li Liu et al.     The soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins are small and abundant membrane-bound proteins, whose specific interactions mediate membrane …             Elevated O3 enhances the attraction of whitefly-infested tomato plants to Encarsia formosa ▶     Hongying Cui, Jianwei Su, Jianing Wei et al.     We experimentally examined the effects of elevated O3 and whitefly herbivory on tomato volatiles, feeding and oviposition preferences of whiteflies and behavioural responses of …             Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses ▶     Mart Krupovic, Eugene V. Koonin     Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small …             Phase-contrast X-ray CT Imaging of Esophagus and Esophageal Carcinoma ▶     Jianfa Zhang, Dongping Tian, Runhua Lin et al.     The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which …             Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus ▶     Mya Myat Ngwe Tun, Kotaro Aoki, Masachika Senba et al.     Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice …             All-optical regulation of gene expression in targeted cells ▶     Yisen Wang, Hao He, Shiyang Li et al.     Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on …             Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis ▶     Amiq Gazdhar, Dirk Lebrecht, Michael Roth et al.     Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired …             Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins ▶     Hiroaki Miyashita, Miho Chikazawa, Natsuki Otaki et al.     Covalent modification of proteins exerts significant effects on their chemical properties and has important functional and regulatory consequences. We now report the …             Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population ▶     Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda et al.     The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk …             Multifunctional Photosensitizer-Based Contrast Agents for Photoacoustic Imaging ▶     Chris Jun Hui Ho, Ghayathri Balasundaram, Wouter Driessen et al.     Photoacoustic imaging is a novel hybrid imaging modality combining the high spatial resolution of optical imaging with the high penetration depth of ultrasound imaging. Here, for …             Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex vivo ▶     Marianne Månsson, Inge Kalies, Göran Bergström et al.     Lipoprotein (a) [Lp(a)] is a low density lipoprotein (LDL) with one apolipoprotein (a) molecule bound to the apolipoprotein B-100 of LDL. Lp(a) is an independent risk factor for …             Short-term effects of different genetically modified maize varieties on arthropod food web properties: an experimental field assessment ▶     Ágnes Szénási, Zoltán Pálinkás, Mihály Zalai et al.     There is concern that genetically modified (GM) plants may have adverse affects on the arthropod biodiversity comprising agricultural landscapes. The present study report on a two …             Chromosome Instability in mouse Embryonic Stem Cells ▶     Nerea Gaztelumendi, Carme Nogués     Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell …             Prioritising in situ conservation of crop resources: A case study of African cowpea (Vigna unguiculata) ▶     C. Moray, E. T. Game, N. Maxted     Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even …             Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology ▶     Feng Li, Dale O. Cowley, Debra Banner et al.     Humanized mouse models have become increasingly important and widely used in modeling human diseases in biomedical research. Immunodeficient mice such as NOD-Rag1-/-IL2RgammaC-null…             Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors ▶     Robert J. Paproski, Andrew Heinmiller, Keith Wachowicz et al.     Photoacoustic imaging is an emerging hybrid imaging technology capable of breaking through resolution limits of pure optical imaging technologies imposed by optical-scattering to …             Parity and pancreatic cancer risk: evidence from a meta-analysis of twenty epidemiologic studies ▶     Beibei Zhu, Li Zou, Juan Han et al.     Multiple studies have hypothesized parity is associated with pancreatic cancer risk but obtained conflicting results. We conducted a meta-analysis (including a dose-response …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Research Technician     University of Sussex            Postdoctoral Fellow     Mayo Clinic            Marie Curie Post-doctoral Fellowships     Human Genetics Foundation            Research Assistant     King's College London            Postdoctoral Fellow     Welcome Trust Sanger Institue            Research Fellow x 2     University of Aberdeen            Bioinformatician     University of Luxembourg            Post Doctoral Fellow     Emory University            Research Fellow     The University of Warwick            Junior Researcher / Assistant Professor position     Umeå University          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events Directory featured events           natureevents directory featured events         International Study Group for Systems Biology 2014: From Cell to Organism     2 September 2014 Durham, UK         Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.                 Your email address is in the Scientific Reports: Biology mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th floor | New York | NY 10013-1917 | USA Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.