Molecular Systems Biology - New articles published - 1 May 2014

April 2014 | Volume 10, Number 4 Submit Table of Contents News & Views Review Addendum Articles News & Views Volume 10, Number 4 News & Views The three most important things about origins: location, location, location The reasons why some DNA replication origins fire earlier than others have remained elusive. New work by Gindin et al suggests that the distribution of replication origins, not their timing, per se, is the major determinant of genome replication timing in human cells. Nicholas Rhind Published online 04.04.2014 Review The functional diversity of protein lysine methylation Lysine methylation is a functionally diverse post‐translational modification found in all living organisms. A comprehensive review of the ~1,000 methylation sites reported to date highlights the involvement of lysine methylation in multiple regulatory networks. Sylvain Lanouette, Vanessa Mongeon, Daniel Figeys, and Jean‐François Couture Published online 08.04.2014 Addendum Periodic mRNA synthesis and degradation co‐operate during cell cycle gene expression Philipp Eser, Carina Demel, Kerstin C Maier, Björn Schwalb, Nicole Pirkl, Dietmar E Martin, Patrick Cramer, and Achim Tresch Published online 25.04.2014 Articles Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean Modern cells possess a sophisticated metabolic network, but its origins remain largely unknown. Reconstructing scenarios of the Archean ocean, we observe chemical reactions reminiscent of modern metabolic sequences, indicating that metabolism could be of prebiotic origin. Markus A Keller, Alexandra V Turchyn, and Markus Ralser Published online 25.04.2014 News & Views Prebiotic metabolic networks? A prebiotic origin of metabolism has been proposed as one of several scenarios for the origin of life. In their recent work, Ralser and colleagues (2014) observe an enzyme‐free, metabolism‐like reaction network under conditions reproducing a possible prebiotic environment. Pier Luigi Luisi Published online 25.04.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.