Drug Discovery@nature.com 2 May 2014

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TABLE OF CONTENTS 2 May 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Immunology & Arkitek Scientific ANIMATION: IMMUNOLOGY IN THE SKIN   Nature Immunology and Arkitek Scientific presents an exciting animated video that describes the environmental and cellular participants in the regulation of barrier function in the healthy and psoriatic skin.   View the Animation for FREE at: www.nature.com/ni/multimedia/skin   Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson    News Top Cancer charity sees success re-prioritizing industry's shelved compounds doi:10.1038/nrd4315 The first two projects of Cancer Research UK's scheme to give second chances to industry's de-prioritized compounds have now run their course, with varying degrees of success. Full Text Zinc-finger nucleases make the cut in HIV doi:10.1038/nrd4316 Sangamo's lead zinc-finger therapeutic supports the potential of gene-editing technology, but CRISPR-based gene-editing therapeutics are close behind. Full Text Trial watch: Personalized medicines in late-stage development doi:10.1038/nrd4325 A recent study has examined the numbers and characteristics of personalized medicines in the late-stage pipeline. Full Text 18 months sliced off Celebrex's patent protection doi:10.1038/nrd4328 Invalidation of a patent covering Pfizer’s anti-inflammatory Celebrex (celecoxib) could allow generics manufacturers to muscle in 18 months earlier than originally anticipated. Full Text Analysis Top R&D productivity: on the comeback trail doi:10.1038/nrd4320 Analysis of the value of new drug approvals over the past two decades, together with spending on R&D, indicates that R&D productivity for industry overall has moved back towards a sustainable level. Full Text CRISPR in the liver doi:10.1038/scibx.2014.447 Venture dollars are flowing into the development of CRISPR-based therapeutics, and proof of concept may come faster than expected as new findings show that the approach can correct a mutation in mice with genetic liver disease. Full Text Research Highlights Top Target identification: Stopping β-cell death in diabetes doi:10.1038/nrd4313 A recently identified regulator of β-cell apoptosis, mammalian STE20-like protein kinase 1 (MST1), could be a new target for the treatment of diabetes. Full Text Anti-inflammatory drugs: 'Fish'ing for regulators of inflammation doi:10.1038/nrd4312 A natural product known as tanshinone IIA can promote the resolution of inflammation by inducing neutrophil apoptosis and reverse migration. Full Text Anticancer drugs: A new weapon against metastatic melanoma doi:10.1038/nrd4314 A recent study in mice has shown that activators of liver X receptor (LXR) can suppress melanoma progression and metastasis. Full Text Research & Reviews Top Targeting bromodomains: epigenetic readers of lysine acetylation doi:10.1038/nrd4286 Inhibiting bromodomains could be a way to alter the expression of disease-promoting genes, and might be used to treat cancer, inflammation and viral infection. Full Text Therapeutic modulation of Notch signalling — are we there yet? doi:10.1038/nrd4252 This article discusses how to intervene therapeutically in the Notch signalling pathway, and highlights current achievements and remaining obstacles. Full Text Interleukin-21: a double-edged sword with therapeutic potential doi:10.1038/nrd4296 The authors describe our current understanding of IL-21 biology, and discuss progress in harnessing this knowledge therapeutically. Full Text Nuclear and cytosolic JNK signalling in neurons doi:10.1038/nrn3729 A review of the neuronal functions of JUN amino-terminal kinases and the therapeutic potential of targeting these molecules in various diseases of the nervous system. Full Text Drug Discovery JOBS of the week Oncology Cell Bio PhD Scientist, Small Molecule Drug Discovery Novartis Institutes for BioMedical Research (NIBR) Drug Delivery Vehicle / Particle Synthesis Expert MIT Kidscan Children�s Cancer Charity: Call for Experts in Cancer Research and Drug Discovery Kidscan Childrens Cancer Charity 4-Year Fully Funded Studentship in "Computation of Allosteric Interactions in Biomolecular Drug Targets�� University of Edinburgh Staff Scientist - Aerosol Drug Delivery Wyss Institute for Biologically Inspired Engineering More Science jobs from Drug Discovery EVENT Malaria Drug Development and Resistance Control 03.07.14 London, UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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