The EMBO Journal Table of Contents for 1 April 2014; Vol. 33, No. 7

1 April 2014 | Volume 33, Number 7 Submit Table of Contents Have you seen? Articles Corrigendum Volume 33, Number 7 Have you seen? Fetal cannabinoid receptors and the “dis‐joint‐ed” brain The psychoactive ingredient of marijuana, THC, disrupts cortical circuitry development by targeting the microtubule‐binding protein SCG10/stathmin‐2. Luigia Cristino and Vincenzo Di Marzo Published online 14.03.2014 Articles Miswiring the brain: Δ9‐tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin‐2 degradation pathway The microtubule binding protein SCG10/stathmin‐2 represents the first molecular effector of cannabis' major psychoactive substance in the developing cerebellum, with consequences for axonal morphology and cortical circuitry development in mammals. Giuseppe Tortoriello, Claudia V Morris, Alan Alpar, Janos Fuzik, Sally L Shirran, Daniela Calvigioni, Erik Keimpema, Catherine H Botting, Kirstin Reinecke, Thomas Herdegen, Michael Courtney, Yasmin L Hurd, and Tibor Harkany Published online 27.01.2014 Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries Actomyosin cables form mechanical barriers in the hindbrain of zebrafish embryos to sort rhombomeric cells into compartments, preventing their cross‐boundary mixing and ensuring proper pattern formation. Simone Calzolari, Javier Terriente, and Cristina Pujades Published online 25.02.2014 A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures Wnt and EGF signals jointly induce the small GTP‐binding protein Arl4c in epithelial cells, which form tubules. Arl4c regulates actin cytoskeleton dynamics through RhoGTPases, and the resulting cell shape changes activate the transcription factor YAP/TAZ, promoting cell proliferation. Shinji Matsumoto, Shinsuke Fujii, Akira Sato, Souji Ibuka, Yoshinori Kagawa, Masaru Ishii, and Akira Kikuchi Published online 20.02.2014 Molecular functions of the TLE tetramerization domain in Wnt target gene repression Bill Weis and colleagues present an unusual tetramer fold for the N‐terminal domain of the Groucho/TLE1 repressor. Their functional results propose chromatin binding, rather than competition for TCF as mechanism for Wnt‐target gene repression. Jayanth V Chodaparambil, Kira T Pate, Margretta R D Hepler, Becky P Tsai, Uma M Muthurajan, Karolin Luger, Marian L Waterman, and William I Weis Published online 03.03.2014 G4 motifs affect origin positioning and efficiency in two vertebrate replicators Genetic manipulation of DNA G‐quadruplex‐forming potential in chicken cell lines provides first evidence for the requirement of G4 structures in vertebrate replication initiation. Anne‐Laure Valton, Vahideh Hassan‐Zadeh, Ingrid Lema, Nicole Boggetto, Patrizia Alberti, Carole Saintomé, Jean‐François Riou, and Marie‐Noëlle Prioleau Published online 12.02.2014 Opposing roles of Ubp3‐dependent deubiquitination regulate replicative life span and heat resistance A conserved deubiquitinase serves dual roles in removal of damaged proteins, feeding them either into a rescue pathway or aiding their proteasome‐mediated degradation. David Öling, Frederik Eisele, Kristian Kvint, and Thomas Nyström Published online 04.03.2014 In vivo inhibition of the mitochondrial H+‐ATP synthase in neurons promotes metabolic preconditioning The mitochondrial F0F1‐ATPase not only functions as the cell's power plant, but also as a pivotal in vivo cell death regulator, emphasizing its potential as a target for therapy. Laura Formentini, Marta P Pereira, Laura Sánchez‐Cenizo, Fulvio Santacatterina, José J Lucas, Carmen Navarro, Alberto Martínez‐Serrano, and José M Cuezva Published online 12.02.2014 Corrigendum Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants Pontus Klein, Anne Kathrin Müller‐Rischart, Elisa Motori, Cornelia Schönbauer, Frank Schnorrer, Konstanze F Winklhofer, and Rüdiger Klein Published online 01.04.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.