Scientific Reports Biology Table of Contents e-alert: 15 April 2014

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15 April 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Designing of promiscuous inhibitors against pancreatic cancer cell lines ▶     Rahul Kumar, Kumardeep Chaudhary, Deepak Singla et al.     Pancreatic cancer remains the most devastating disease with worst prognosis. There is a pressing need to accelerate the drug discovery process to identify new effective drug …             Whole-genome sequencing of Berkshire (European native pig) provides insights into its origin and domestication ▶     Mingzhou Li, Shilin Tian, Carol K. L. Yeung et al.     Domesticated organisms have experienced strong selective pressures directed at genes or genomic regions controlling traits of biological, agricultural or medical importance. The …             Mechanosensitive physiology of chlamydomonas reinhardtii under direct membrane distortion ▶     Seul Ki Min, Gwang Heum Yoon, Jung Hyun Joo et al.     Cellular membrane distortion invokes variations in cellular physiology. However, lack of an appropriate system to control the stress and facilitate molecular analyses has hampered …             Biochar and Glomus caledonium Influence Cd Accumulation of Upland Kangkong (Ipomoea aquatica Forsk.) Intercropped with Alfred Stonecrop (Sedum alfredii Hance) ▶     Junli Hu, Fuyong Wu, Shengchun Wu et al.     Both biochar application and mycorrhizal inoculation have been proposed to improve plant growth and alter bioaccumulation of toxic metals. A greenhouse pot trial was conducted to …             Ultra Q-bodies: quench-based antibody probes that utilize dye-dye interactions with enhanced antigen-dependent fluorescence ▶     Ryoji Abe, Hee-Jin Jeong, Dai Arakawa et al.     Recently, we described a novel reagentless fluorescent biosensor strategy named Quenchbody, which functions via the antigen-dependent removal of the quenching effect on a …             A simple, inexpensive method for preparing cell lysates suitable for downstream reverse transcription quantitative PCR ▶     Kenneth Shatzkes, Belete Teferedegne, Haruhiko Murata     Sample nucleic acid purification can often be rate-limiting for conventional quantitative PCR (qPCR) workflows. We recently developed high-throughput virus microneutralization …             TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli ▶     Pauliina M. Munne, Yuexi Gu, Manuela Tumiati et al.     Multiple observations suggest a cell type-specific role for TP53 in mammary epithelia. We developed an in vitro assay, in which primary mouse mammary epithelial cells (mMECs) …             Functional Genomics Evidence Unearths New Moonlighting Roles of Outer Ring Coat Nucleoporins ▶     Katerina R. Katsani, Manuel Irimia, Christos Karapiperis et al.     There is growing evidence for the involvement of Y-complex nucleoporins (Y-Nups) in cellular processes beyond the inner core of nuclear pores of eukaryotes. To comprehensively …             Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery ▶     Sylwia Bobis-Wozowicz, Melanie Galla, Jamal Alzubi et al.     Designer nucleases, like zinc-finger nucleases (ZFNs), represent valuable tools for targeted genome editing. Here, we took advantage of the gamma-retroviral life cycle and …             Weaker signals induce more precise temporal-integration ▶     Yoshiaki Tsushima     It is well known that our perceptual system integrates local information to generate global percepts. Although events in the real world occur over time, it is still unclear how we …             A comparative analysis of spatial Prisoner's Dilemma experiments: Conditional cooperation and payoff irrelevance ▶     Jelena Gruji, Carlos Gracia-Lzaro, Manfred Milinski et al.     We have carried out a comparative analysis of data collected in three experiments on Prisoner's Dilemmas on lattices available in the literature. We focus on the different ways in …             Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients ▶     En-Zhi Jia, Zhao-Hong Chen, Feng-Hui An et al.     We performed a large, long-term cohort study to evaluate the association of renin-angiotensin-aldosterone system gene polymorphisms and baseline phenotypes to all-cause mortality …             Enzyme-free Passage of Human Pluripotent Stem Cells by Controlling Divalent Cations ▶     Kiyoshi Ohnuma, Ayaka Fujiki, Kana Yanagihara et al.     Enzymes used for passaging human pluripotent stem cells (hPSCs) digest cell surface proteins, resulting in cell damage. Moreover, cell dissociation using divalent cation-free …             Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque ▶     Yue-Mei Fan, Jussi Hernesniemi, Niku Oksala et al.     Upstream transcription factor 1 (USF1) allelic variants significantly influence future risk of cardiovascular disease and overall mortality in females. We investigated …             Regeneration of Aplysia Bag Cell Neurons is Synergistically Enhanced by Substrate-Bound Hemolymph Proteins and Laminin ▶     Callen Hyland, Eric R. Dufrense, Paul Forscher     We have investigated Aplysia hemolymph as a source of endogenous factors to promote regeneration of bag cell neurons. We describe a novel synergistic effect between …             Archaeal amoA and ureC genes and their transcriptional activity in the Arctic Ocean ▶     Estelle Pedneault, Pierre E. Galand, Marianne Potvin et al.     Thaumarchaeota and the gene encoding for a subunit of ammonia monooxygenase (amoA) are ubiquitous in Polar Seas, and some Thaumarchaeota also have a gene coding for ureC, …             Enhanced Antibacterial Activity of Silver Nanoparticles/Halloysite Nanotubes/Graphene Nanocomposites with Sandwich-Like Structure ▶     Liang Yu, Yatao Zhang, Bing Zhang et al.     A sandwich-like antibacterial reagent (Ag/HNTs/rGO) was constructed through the direct growth of silver nanoparticles on the surface graphene-based HNTs nanosheets. Herein, …             Mast cell-derived serine proteinase regulates T helper 2 polarization ▶     Zhi-Qiang Liu, Jiang-Ping Song, Xiaoyu Liu et al.     Although mast cells play a critical role in allergic reactions, the cells are also involved in the protective immunity in the body. This study aims to investigate the role of mast …             Palpitomonas bilix represents a basal cryptist lineage: insight into the character evolution in Cryptista ▶     Akinori Yabuki, Ryoma Kamikawa, Sohta A. Ishikawa et al.     Phylogenetic position of the marine biflagellate Palpitomonas bilix is intriguing, since several ultrastructural characteristics implied its evolutionary connection to …             Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis ▶     Simin Zhang, Qiuqin Tang, Wei Wu et al.     Several studies have investigated the association between polymorphisms in the Deleted in AZoospermia-Like (DAZL) gene and male infertility risk, but with inconsistent results. We …             Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice ▶     Yosuke Nakayama, Tomohiro Moriya, Fumihiko Sakai et al.     The Lactobacillus gasseri SBT2055 (LG2055) is a probiotic lactic acid bacterium with properties such as bile tolerance and ability to improve the intestinal environment. In this …             Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids ▶     James A. Ankrum, Riddhi G. Dastidar, Joon Faii Ong et al.     Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of …             Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism ▶     Qingyu Zhang, Jie Liu, Bin Liu et al.     The development of antitumor chemotherapy drugs remains a key goal for oncologists, and natural products provide a vast resource for anti-cancer drug discovery. In the current …             Articulated Wiwaxia from the Cambrian Stage 3 Xiaoshiba Lagerstätte ▶     Jie Yang, Martin R. Smith, Tian Lan et al.     Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed …             Body size as a predictor of species loss effect on ecosystem functioning ▶     Annie Sguin, ric Harvey, Philippe Archambault et al.     There is an urgent need to develop predictive indicators of the effect of species loss on ecosystem functioning. Body size is often considered as a good indicator because of its …             Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation ▶     Mingxi Yao, Benjamin T. Goult, Hu Chen et al.     The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the …             The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion ▶     Yuan Liang, Yu Sun, Xiaolei Li et al.     10-Hydroxycamptothecin could reduce intraarticular adhesion by inhibiting fibroblasts proliferation after knee surgery. However, the ideal concentration of hydroxycamptothecin …             Reduced growth and proliferation dynamics of nasal epithelial stem/progenitor cells in nasal polyps in vitro ▶     Xue Min Yu, Chun Wei Li, Siew Shuen Chao et al.     Basal cells in nasal epithelium have stemness/progenitor characters and play essential roles in the epithelial remodeling in nasal polyps (NP). We investigate whether the human …             A color-tunable molecular beacon to sense miRNA-9 expression during neurogenesis ▶     Hae Young Ko, Jonghwan Lee, Jin Young Joo et al.     A typical molecular beacon (MB) composing of a fluorophore and a quencher has been used to sense various intracellular biomolecules including microRNAs (miRNA, miR). However, the …             Pharmacological targeting of the -amyloid precursor protein intracellular domain ▶     Caterina Branca, Ilenia Sarnico, Roberta Ruotolo et al.     Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression causes various …             Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations ▶     Josep Sardanys, Carles Sim, Regina Martnez et al.     The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a …             Combined Volatolomics for Monitoring of Human Body Chemistry ▶     Yoav Y. Broza, Liat Zuri, Hossam Haick     Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for …             In vitro model suggests oxidative stress involved in keratoconus disease ▶     D. Karamichos, A. E. K. Hutcheon, C. B. Rich et al.     Keratoconus (KC) affects 1:2000 people and is a disorder where cornea thins and assumes a conical shape. Advanced KC requires surgery to maintain vision. The role of oxidative …             Increased apomixis expression concurrent with genetic and epigenetic variation in a newly synthesized Eragrostis curvula polyploid ▶     Diego C. Zappacosta, Ana C. Ochogava, Juan M. Rodrigo et al.     Eragrostis curvula includes biotypes reproducing through obligate and facultative apomixis or, rarely, full sexuality. We previously generated a tetraploid-dihaploid-tetraploid …             Derivation of human decidua-like cells from amnion and menstrual blood ▶     Kana Sugawara, Toshio Hamatani, Mitsutoshi Yamada et al.     We induced differentiation of human amnion-derived mesenchymal stem cells (AMCs) and menstrual blood-derived mesenchymal stem cells (MMCs) into endometrial stroma-like cells, …             Non-site-specific allosteric effect of oxygen on human hemoglobin under high oxygen partial pressure ▶     Masayoshi Takayanagi, Ikuo Kurisaki, Masataka Nagaoka     Protein allostery is essential for vital activities. Allosteric regulation of human hemoglobin (HbA) with two quaternary states T and R has been a paradigm of allosteric …             From Commodity Polymers to Functional Polymers ▶     Tao Xiang, Ling-Ren Wang, Lang Ma et al.     Functional polymers bear specified chemical groups, and have specified physical, chemical, biological, pharmacological, or other uses. 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