Nature Reviews Cancer contents Month May Volume 14 Number 5 pp 291-380

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TABLE OF CONTENTS
May 2014 Volume 14 Number 5		Advertisement
Impact Factor 35*	In this issue Comment Research Highlights Reviews Perspectives Also this month Featured article: Clinical insights  Featured article: Unravelling mechanisms of p53-mediated tumour suppression Kathryn T. Bieging, Stephano Spano Mello & Laura D. Attardi	Speed. Resolution. Clarity. Accuracy. The Hamamatsu NanoZoomer Series delivers all of this and more. The ultimate digital whole-slide scanner and virtual microscopy tool, the NanoZoomer delivers reliable, robust scanning 24/7/365. Features include high sensitivity, fast scanning, flexible fluorescence capabilities, and a Z-stack feature to accommodate thicker tissue samples.
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Article series: Clinical insights Comment: Mining the genomes of exceptional responders David K. Chang, Sean M. Grimmond, T. R. Jeffry Evans & Andrew V. Biankin Published online: 27 March 2014 p291 | doi:10.1038/nrc3723 We now have immensely powerful tools to begin to discern even subtle differences that might explain why certain cancer patients have exceptional responses to therapy. What can we expect to learn from these exceptional responders and how do we approach studying them? Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Tumour heterogeneity: A cooperative tumour cell community Published online: 17 April 2014 p294 | doi:10.1038/nrc3732 Functional cooperation occurs between unique subclones within an individual tumour in a mouse mammary tumour virus (MMTV)-WNT1 mouse model of breast cancer. PDF Breast cancer: Hypoxia and XBP1S Published online: 10 April 2014 p295 | doi:10.1038/nrc3731 This paper reports that the spliced form of X-box-binding protein 1, which is activated as part of the unfolded protein response, regulates a hypoxia-inducible factor 1α-dependent transcriptional network in triple-negative breast cancer cells. PDF Tumour suppressors: Master weaver regulates guardian Published online: 17 April 2014 p295 | doi:10.1038/nrc3733 CCCTC-binding factor (CTCF) is involved in the regulation of the tumour suppressor p53 through binding to the TP53 antisense transcript WRAP53. PDF Microenvironment: Tumour-promoting tissue mechanics Published online: 04 April 2014 p296 | doi:10.1038/nrc3727 Mouw et al. show that increased extracellular matrix stiffness induces tumorigenic signalling circuits. PDF DNA damage: De-sanitizing tumour cells Published online: 17 April 2014 p296 | doi:10.1038/nrc3734 Two papers find that targeting MTH1, an enzyme that prevents the incorporation of oxidized purine nucleotides into DNA, causes lethality in various tumour cell lines. PDF Microenvironment: Endothelial cells create a niche Published online: 10 April 2014 p298 | doi:10.1038/nrc3730 Shahin Rafii, Bi-Sen Ding and colleagues show that crosstalk between endothelial cells and lymphoma cells promotes lymphomagenesis and resistance to chemotherapy. PDF IN BRIEF Colorectal cancer: Editing an invasion | Dedifferentiation: A point of return | Lung cancer: Overcoming crizotinib resistance | Immunotherapy: Understanding side effects | Therapeutic resistance: Like colon, like melanoma | Signalling: A mevalonate pathway-Hippo pathway connection | Tumour immunology: Characterizing the tumour microenvironment PDF Cancer JOBS of the week Postdoctoral Position in Liver Cancer Biology Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai Faculty Positions in Cancer Biology University of Cincinnati Postdoctoral Researcher OHSU / Knight Cancer Institute Oregon Health & Science University (OHSU) Postdoctoral Position in Hypoxia Signaling in Cancer ETH Zurich Cancer Computational Biology Princess Margaret Cancer Centre More Science jobs from Cancer EVENT 2nd Breast Cancer in Young Women Conference (BCY2) 06.11.14 Tel Aviv, Israel More science events from
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REVIEWS		Top
Principles and methods of integrative genomic analyses in cancer Vessela N. Kristensen, Ole Christian Lingjærde, Hege G. Russnes, Hans Kristian M. Vollan, Arnoldo Frigessi & Anne-Lise Børresen-Dale Published online: 24 April 2014 p299 | doi:10.1038/nrc3721 Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and protein expression, point to biological functions and molecular pathways being deregulated in multiple cancers. The integrative genomics methodologies that are used to interpret these data can seem daunting, but are discussed in this Review in simplistic terms and in the context of their use in cancer research. Abstract | Full Text | PDF
Developments in preclinical cancer imaging: innovating the discovery of therapeutics James R. W. Conway, Neil O. Carragher & Paul Timpson Published online: 17 April 2014 p314 | doi:10.1038/nrc3724 Conway and colleagues provide a comprehensive overview of imaging techniques as pertaining to their use in identifying new drugs for cancer therapy. Abstract | Full Text | PDF
IGF binding proteins in cancer: mechanistic and clinical insights Robert C. Baxter Published online: 10 April 2014 p329 | doi:10.1038/nrc3720 The family of insulin-like growth factor (IGF) binding proteins (IGFBPs) have many actions beyond their endocrine role in IGF transport. IGFBPs regulate cell growth and survival, gene transcription, induction of apoptosis and DNA damage repair. These findings point to the intimate involvement of IGFBPs in tumour development, progression and resistance to treatment. Abstract | Full Text | PDF | Supplementary information
The role of vitamin D in reducing cancer risk and progression David Feldman, Aruna V. Krishnan, Srilatha Swami, Edward Giovannucci & Brian J. Feldman Published online: 04 April 2014 p342 | doi:10.1038/nrc3691 Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, this Review assesses the evidence that vitamin D is important in cancer prevention. Abstract | Full Text | PDF | Supplementary information
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PERSPECTIVES		Top
OPINION Unravelling mechanisms of p53-mediated tumour suppression Kathryn T. Bieging, Stephano Spano Mello & Laura D. Attardi Published online: 17 April 2014 p359 | doi:10.1038/nrc3711 There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour suppression has remained challenging. As new roles for p53 emerge, this Opinion dissects the role of p53 in tumour suppression. Abstract | Full Text | PDF
OPINION Turning ecology and evolution against cancer Kirill S. Korolev, Joao B. Xavier & Jeff Gore Published online: 17 April 2014 p371 | doi:10.1038/nrc3712 This Opinion article discusses how principles that are applied to the study of ecology might be relevant to the study of cancer. Focusing on population dynamics, this article provides suggestions and ideas for understanding tumour growth and how this might provide strategies for eradication. Abstract | Full Text | PDF
CORRIGENDUM Maintaining and reprogramming genomic androgen receptor activity in prostate cancer Ian G. Mills Published online: 20 March 2014 p380 | doi:10.1038/nrc3722 Full Text | PDF
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