Drug Discovery@nature.com 25 April 2014

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TABLE OF CONTENTS 25 April 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Reviews Neuroscience  FREE POSTER - BDNF function in health and disease   This Poster summarizes the molecular functions of BDNF in the CNS and highlights its therapeutic potential for conditions such as Alzheimer's disease, Parkinson's disease, stroke and spinal cord injury.   This poster is freely available thanks to support from EVER Neuro Pharma    News Top RNA interference rebooted doi:10.1038/508443a Gene-silencing technique yields promising treatments for liver-linked disorders. Full Text Tamiflu report comes under fire doi:10.1038/508439a Conclusions on stockpiling of antiviral drugs challenged. Full Text Regrown nerves boost bionic ears doi:10.1038/nature.2014.15082 Gene therapy aids performance of cochlear impants in guinea pigs. Full Text Start-up investor bets on biotech doi:10.1038/nature.2014.15096 Y Combinator has high hopes for low-cost biotech innovation. Full Text Analysis Top Contaminating cancer genomes doi:10.1038/scibx.2014.418 Two teams have pinpointed a DNA-protective enzyme as a chemically tractable target whose inhibition kills cancer cells by accelerating DNA damage, and are looking to partner with industry. Full Text The COPD pipeline doi:10.1038/nrd4254 Therapeutic approaches to treat chronic obstructive pulmonary disease (COPD) are varied, and recent approvals have diversified treatment options. Full Text Research Highlights Top Antibacterial drugs: Redesigned antibiotic combats drug-resistant tuberculosis doi:10.1038/nrd4287 A novel class of anti-TB agents, called spectinamides, has shown activity against multidrug-resistant TB. Full Text Cancer: Live screening of immunotherapy targets doi:10.1038/nrd4289 A new study has outlined an approach for the in vivo discovery of immunotherapy targets in melanoma using RNA interference technology. Full Text Neurodegenerative disease: Searching for the weak spots doi:10.1038/nrd4284 Matrix metalloproteinase 9 could be a promising therapeutic target for amyotrophic lateral sclerosis. Full Text Research & Reviews Top Aquaporins: important but elusive drug targets doi:10.1038/nrd4226 The authors discuss the therapeutic potential of targeting aquaporin channels as well as associated challenges, such as the suitability of assay methods. Full Text Targeting the pancreatic β-cell to treat diabetes doi:10.1038/nrd4231 Wagner and colleagues discuss strategies to promote β-cell proliferation, survival and function for the treatment of diabetes, and consider ongoing challenges to drug development efforts that are aimed at targeting this cell population. Full Text Advances in targeting cyclic nucleotide phosphodiesterases doi:10.1038/nrd4228 A review of how recent understanding of the roles of individual cyclic nucleotide phosphodiesterases (PDEs) is aiding the development of more sophisticated strategies to target individual PDE variants. Full Text Pathological pain and the neuroimmune interface doi:10.1038/nri3621 The authors explain how the immune and nervous systems interact to initiate and propagate pain, and discuss the immune components that can be targeted for alleviating pathological pain in patients. Full Text Drug Discovery JOBS of the week PhD Scholarship in �Novel nanomedicines for targeted drug delivery to the back of the eye� Technical University of Denmark (DTU) Oncology Cell Bio PhD Scientist, Small Molecule Drug Discovery Novartis Institutes for BioMedical Research (NIBR) Drug Delivery Vehicle / Particle Synthesis Expert MIT Kidscan Children�s Cancer Charity: Call for Experts in Cancer Research and Drug Discovery Kidscan Childrens Cancer Charity Tenure-Track and Postdoctoral Scientists in Molecular Profiling Research Center for Drug Discovery, AIST National Institute Advanced Industrial Science and Technology (AIST) More Science jobs from Drug Discovery EVENT Malaria Drug Development and Resistance Control 03.07.14 London, UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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