Drug Discovery@nature.com 17 April 2014

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View the Animation for FREE at: www.nature.com/ni/multimedia/skin Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson    News Top Metabolic quirks yield tumour hope doi:10.1038/508158a Early clinical-trial results show promise for targeting cancer-related biochemical pathways. Full Text Hepatitis C drugs not reaching poor doi:10.1038/508295a Treatment guidelines for the virus highlight challenge of paying for expensive drugs in low-income countries. Full Text Immune-checkpoint inhibitors march on, now in combinations doi:10.1038/nbt0414-297 The pace of deal-making in cancer immunotherapy has picked up sharply, and shows big pharma’s interest in combining this approach with other therapies such as vaccines and small-molecule drugs. Full Text Adaptive methods help drug sponsors find best treatment dose doi:10.1038/nm0414-321 A new effort is underway to facilitate adaptive dose finding in clinical trials. Full Text Analysis Top Pre-EMP-tive strike against GBM doi:10.1038/scibx.2014.389 Researchers have treated glioblastoma in mice by inhibiting epithelial membrane protein 2 (EMP2), opening up a new indication for an EMP2-targeted antibody in development for breast cancer. Full Text The COPD pipeline doi:10.1038/nrd4254 Therapeutic approaches to treat chronic obstructive pulmonary disease (COPD) are varied, and recent approvals have diversified treatment options. Full Text Research Highlights Top Antibacterial drugs: Redesigned antibiotic combats drug-resistant tuberculosis doi:10.1038/nrd4287 A novel class of anti-TB agents, called spectinamides, has shown activity against multidrug-resistant TB. Full Text Cancer: Live screening of immunotherapy targets doi:10.1038/nrd4289 A new study has outlined an approach for the in vivo discovery of immunotherapy targets in melanoma using RNA interference technology. Full Text Neurodegenerative disease: Searching for the weak spots doi:10.1038/nrd4284 Matrix metalloproteinase 9 could be a promising therapeutic target for amyotrophic lateral sclerosis. Full Text Research & Reviews Top Aquaporins: important but elusive drug targets doi:10.1038/nrd4226 The authors discuss the therapeutic potential of targeting aquaporin channels as well as associated challenges, such as the suitability of assay methods. Full Text Targeting the pancreatic β-cell to treat diabetes doi:10.1038/nrd4231 Wagner and colleagues discuss strategies to promote β-cell proliferation, survival and function for the treatment of diabetes, and consider ongoing challenges to drug development efforts that are aimed at targeting this cell population. Full Text Advances in targeting cyclic nucleotide phosphodiesterases doi:10.1038/nrd4228 A review of how recent understanding of the roles of individual cyclic nucleotide phosphodiesterases (PDEs) is aiding the development of more sophisticated strategies to target individual PDE variants. Full Text Pathological pain and the neuroimmune interface doi:10.1038/nri3621 The authors explain how the immune and nervous systems interact to initiate and propagate pain, and discuss the immune components that can be targeted for alleviating pathological pain in patients. Full Text Drug Discovery JOBS of the week Kidscan Children’s Cancer Charity: Call for Experts in Cancer Research and Drug Discovery Kidscan Childrens Cancer Charity Post-Doctoral Research Fellow, Drug Discovery / Project Violet - Optide Fred Hutchinson Cancer Research Center Postdoc in Cancer Drug Delivery University of Tartu PhD Position on Bionanotechnology for Sensing, Drug Delivery and Cell Culture Universitat Rovira i Virgili-DEEEA Staff Scientist - Aerosol Drug Delivery Wyss Institute for Biologically Inspired Engineering More Science jobs from Drug Discovery EVENT 15th International Conference on Alzheimer’s Drug Discovery 08.09.14 New Jersey, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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