Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 95 Issue 5

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Download the Autoimmune Application Notes TABLE OF CONTENTS Volume 95, Issue 5 (May 2014) In this issue In This Issue Editorial News & Views Perspectives Discovery & Development CPIC Update State of the Art Research Also new AOP Sign up for CPT: Pharmacometrics & Systems Pharmacology e-alerts Sign up for e-alerts Recommend to your library Web feed Subscribe In This Issue Top In This Issue Clin Pharmacol Ther 2014 95: 453; 10.1038/clpt.2014.58 Full Text Editorial Top Intelligent Pharmaceuticals: Beyond the Tipping Point P Honig and S-M Huang Clin Pharmacol Ther 2014 95: 455-459; 10.1038/clpt.2014.32 Abstract | Full Text News & Views Top HIGHLIGHTS Clin Pharmacol Ther 2014 95: 460-461; 10.1038/clpt.2014.57 Full Text ASCPT NEWS Clin Pharmacol Ther 2014 95: 462-465; 10.1038/clpt.2014.53 Full Text Perspectives Top COMMENTARIES Recent Trends and Success Factors in Reducing the Lag Time to Approval of New Drugs in Japan P K Honig Clin Pharmacol Ther 2014 95: 467-469; 10.1038/clpt.2013.256 Abstract | Full Text Promise and Challenges With the Use of Mobile Applications to Support and Improve Patient Care: An Industry Perspective K W Bucklen and B M Abbott Clin Pharmacol Ther 2014 95: 469-471; 10.1038/clpt.2014.34 Abstract | Full Text The Role of Academic Medical Centers in Advancing Regulatory Science R J Meyer Clin Pharmacol Ther 2014 95: 471-473; 10.1038/clpt.2014.33 Full Text Itraconazole and Clarithromycin as Ketoconazole Alternatives for Clinical CYP3A Inhibition Studies A B Ke, M J Zamek-Gliszczynski, J W Higgins and S D Hall Clin Pharmacol Ther 2014 95: 473-476; 10.1038/clpt.2014.41 Abstract | Full Text Mobile Medical Applications: Old Wine in New Bottles? R S Epstein Clin Pharmacol Ther 2014 95: 476-478; 10.1038/clpt.2014.35 Abstract | Full Text Physiologically Based Pharmacokinetic Modeling: From Regulatory Science to Regulatory Policy V Sinha, P Zhao, S M Huang and I Zineh Clin Pharmacol Ther 2014 95: 478-480; 10.1038/clpt.2014.46 Abstract | Full Text Modeling and Simulation of Biopharmaceutical Performance X Zhang and R A Lionberger Clin Pharmacol Ther 2014 95: 480-482; 10.1038/clpt.2014.40 Full Text Drug Development in Serious Diseases: The New “Breakthrough Therapy” Designation J Woodcock Clin Pharmacol Ther 2014 95: 483-485; 10.1038/clpt.2014.23 Abstract | Full Text The FDA’s Role in the Development of Medical Mobile Applications J Shuren Clin Pharmacol Ther 2014 95: 485-488; 10.1038/clpt.2014.45 Abstract | Full Text LETTERS TO THE EDITOR Can CYP3A Activity Be Evaluated for Drug Interaction Using a Nanogram Dose of Probe Drug? C Oo and K L Duchin Clin Pharmacol Ther 2014 95: 489; advance online publication, January 10, 2014; 10.1038/clpt.2014.6 Full Text Response to “Can CYP3A Activity Be Evaluated for Drug Interaction Using a Nanogram Dose of Probe Drug?”: Evaluation of CYP3A Activity With Microdoses of Midazolam N Hohmann, B Halama, N Siller, G Mikus and W E Haefeli Clin Pharmacol Ther 2014 95: 490-491; advance online publication, February 6, 2014; 10.1038/clpt.2014.28 Full Text Discovery & Development Top DEVELOPMENT The Role of Big Data and Advanced Analytics in Drug Discovery, Development, and Commercialization N Szlezák, M Evers, J Wang and L Pérez Clin Pharmacol Ther 2014 95: 492-495; advance online publication, February 20, 2014; 10.1038/clpt.2014.29 Abstract | Full Text Exploring the FDA Adverse Event Reporting System to Generate Hypotheses for Monitoring of Disease Characteristics H Fang, Z Su, Y Wang, A Miller, Z Liu, P C Howard, W Tong and S M Lin Clin Pharmacol Ther 2014 95: 496-498; advance online publication, January 21, 2014; 10.1038/clpt.2014.17 Abstract | Full Text CPIC Update Top Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 Update M A Martin, J M Hoffman, R R Freimuth, T E Klein, B J Dong, M Pirmohamed, J K Hicks, M R Wilkinson, D W Haas and D L Kroetz Clin Pharmacol Ther 2014 95: 499-500; advance online publication, February 21, 2014; 10.1038/clpt.2014.38 Abstract | Full Text State of the Art Top Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science L Johannesen, J Vicente, R A Gray, L Galeotti, Z Loring, C E Garnett, J Florian, M Ugander, N Stockbridge and D G Strauss Clin Pharmacol Ther 2014 95: 501-508; advance online publication, December 12, 2013; 10.1038/clpt.2013.238 Abstract | Full Text Advances in Inhaled Technologies: Understanding the Therapeutic Challenge, Predicting Clinical Performance, and Designing the Optimal Inhaled Product P Bäckman, H Adelmann, G Petersson and C B Jones Clin Pharmacol Ther 2014 95: 509-520; advance online publication, February 6, 2014; 10.1038/clpt.2014.27 Abstract | Full Text The Paradox of Scientific Excellence and the Search for Productivity in Pharmaceutical Research and Development T H Grasela and R Slusser Clin Pharmacol Ther 2014 95: 521-527; advance online publication, January 23, 2014; 10.1038/clpt.2013.242 Abstract | Full Text The Biotechnology Innovation Machine: A Source of Intelligent Biopharmaceuticals for the Pharma Industry—Mapping Biotechnology’s Success R P Evens and K I Kaitin Clin Pharmacol Ther 2014 95: 528-532; advance online publication, January 21, 2014; 10.1038/clpt.2014.14 Abstract | Full Text Research Top ARTICLES Significant Differences in Drug Lag in Clinical Development Among Various Strategies Used for Regulatory Submissions in Japan T Ueno, Y Asahina, A Tanaka, H Yamada, M Nakamura and Y Uyama Clin Pharmacol Ther 2014 95: 533-541; advance online publication, November 8, 2013; 10.1038/clpt.2013.223 Abstract | Full Text Assessment of Factors Associated With Dose Differences Between Japan and the United States F L Arnold, S Fukunaga, M Kusama, N Matsuki and S Ono Clin Pharmacol Ther 2014 95: 542-549; advance online publication, November 26, 2013; 10.1038/clpt.2013.231 Abstract | Full Text PBPK Model Describes the Effects of Comedication and Genetic Polymorphism on Systemic Exposure of Drugs That Undergo Multiple Clearance Pathways M d L T Vieira, M-J Kim, S Apparaju, V Sinha, I Zineh, S-M Huang and P Zhao Clin Pharmacol Ther 2014 95: 550-557; advance online publication, February 20, 2014; 10.1038/clpt.2014.43 Abstract | Full Text Exposure–Response Relationship of T-DM1: Insight Into Dose Optimization for Patients With HER2-Positive Metastatic Breast Cancer J Wang, P Song, S Schrieber, Q Liu, Q Xu, G Blumenthal, L Amiri Kordestani, P Cortazar, A Ibrahim, R Justice, Y Wang, S Tang, B Booth, N Mehrotra and A Rahman Clin Pharmacol Ther 2014 95: 558-564; advance online publication, January 31, 2014; 10.1038/clpt.2014.24 Abstract | Full Text Please note that you need to be a subscriber or site-license holder to enjoy full-text access to Clinical Pharmacology & Therapeutics. 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