Nature Reviews Neuroscience contents April 2014 Volume 15 Number 4 pp 203-278

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TABLE OF CONTENTS
April 2014 Volume 15 Number 4
Impact Factor 31.673 *	In this issue Research Highlights Progress Reviews Also this month  Featured article: The log-dynamic brain: how skewed distributions affect network operations György Buzsáki & Kenji Mizuseki
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RESEARCH HIGHLIGHTS Top Neurogenesis: A striatal supply of new neurons p203 | doi:10.1038/nrn3714 Adult neurogenesis occurs in the human striatum. PDF Sensory systems: The hungry sense p204 | doi:10.1038/nrn3711 In mice, the endocannabinoid system inhibits glutamatergic signalling from the olfactory cortex to the main olfactory bulb after fasting, increasing the detection of food odours and, consequently, enhancing food consumption. PDF Neuroimmunology: Obesity inflames memory circuits p204 | doi:10.1038/nrn3713 Adipose-derived interleukin-1β may mediate memory deficits in a mouse model of obesity. PDF Sensory systems: Staying silent p205 | doi:10.1038/nrn3715 Olfactory receptors signal through G protein βγ subunits to silence the expression of other olfactory receptors within a single olfactory sensory neuron. PDF Circadian rhythms: Methylation mediates clock plasticity p206 | doi:10.1038/nrn3712 The period length of the circadian clock in the suprachiasmatic nucleus can be modulated by changes in DNA methylation induced by shortening the light-dark cycle. PDF Synaptic transmission: Invasion of the astrocytes! p206 | doi:10.1038/nrn3720 Connexin 30 regulates synaptic transmission by controlling the extension of astrocytic processes into the synaptic cleft. PDF Sensory systems: A touch of regulation p207 | doi:10.1038/nrn3721 Opioids, acting mainly via δ-opioid receptors, may provide broad control of cutaneous mechanosensation, including touch. PDF IN BRIEF Synaptic physiology: Sprint or steady pace | Neuropharmacology: Switching on the light | Pain: Stopping pain in its tracks | Learning and memory: Don't forget the CA2 PDF Neuroscience JOBS of the week Postdoctoral Fellow in Developmental Neuroscience Children's National Medical Center Postdoctoral Fellow in Neuroscience Northwestern University Research Assistant - fMRI connectivity of the Mouse Brain Istituto Italiano di Tecnologia (IIT) PhD student position in retinal research Universität Tübingen Postdoctoral Researcher Buck Institute for Research on Aging More Science jobs from Neuroscience EVENT Computational Neuroscience: Vision 11.07.14 Cold Spring Harbor, USA More science events from
PROGRESS		Top
Microglial phagocytosis of live neurons Guy C. Brown & Jonas J. Neher p209 | doi:10.1038/nrn3710 Microglia are known to remove dead and dying neurons in the brain by phagocytosis. In this Progress article, Brown and Neher discuss recent evidence indicating that, in certain situations, microglia can instigate the death of viable neurons through phagocytosis, a process they term phagoptosis. Abstract | Full Text | PDF
REVIEWS		Top
Growth and folding of the mammalian cerebral cortex: from molecules to malformations Tao Sun & Robert F. Hevner p217 | doi:10.1038/nrn3707 The size and the extent of gyrification of the cerebral cortex both influence brain function in mammals. In this Review, Sun and Hevner examine the mechanisms underlying cortical growth and folding, and discuss how dysfunction in these processes leads to cortical malformations. Abstract | Full Text | PDF
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases Claudio Hetz & Bertrand Mollereau p233 | doi:10.1038/nrn3689 The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Here, Hetz and Mollereau provide an overview of the most recent findings addressing the relevance of ER stress in the nervous system. Abstract | Full Text | PDF
Electrical synapses and their functional interactions with chemical synapses Alberto E. Pereda p250 | doi:10.1038/nrn3708 Synaptic transmission occurs through two main modalities — namely, chemical and electrical transmission. In this Review, Pereda discusses the complex nature of electrical transmission and explores the mounting evidence that chemical and electrical synapses functionally interact both during development and in adulthood. Abstract | Full Text | PDF
The log-dynamic brain: how skewed distributions affect network operations György Buzsáki & Kenji Mizuseki p264 | doi:10.1038/nrn3687 Many physiological and anatomical parameters in the brain have a skewed distribution. Buzsaki and Mizuseki propose that this reflects a fundamental aspect of brain organization — namely, a network in which a minority of neurons does most of the work all of the time. Abstract | Full Text | PDF
Corrigendum: Functional MRI-based lie detection: scientific and societal challenges Martha J. Farah, J. Benjamin Hutchinson, Elizabeth A. Phelps & Anthony D. Wagner p278 | doi:10.1038/nrn3702 Full Text | PDF
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