Nature Reviews Molecular Cell Biology contents March 2014 Volume 15 Number 4 pp 219-294

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TABLE OF CONTENTS
April 2014 Volume 15 Number 4
Impact Factor 37.162 *	In this issue Research Highlights Reviews Analysis Perspectives Also this month  Featured article: Metabolic requirements for the maintenance of self-renewing stem cells Keisuke Ito & Toshio Suda
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Total Transcription 2014 (1-5 September 2014)  Wellcome Trust Genome Campus, Hinxton, UK This joint Wellcome Trust/Biochemical Society conference will bring together leading researchers in structural and molecular biology, biophysics, genetics, computational modelling, and systems and synthetic biology.  Application & Abstract Deadline: 1 May 2014 www.wellcome.ac.uk/conferences
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RESEARCH HIGHLIGHTS Top Chromatin: ERK keeps promoters 'poised' for action p219 | doi:10.1038/nrm3773 ERK2 is a key regulator of the 'poised' state of developmental genes, as it promotes PRC2-mediated trimethylation of H3K27 and converts RNAPII to RNAPII(S5P). PDF Mitosis: A safety net for successful mitosis p220 | doi:10.1038/nrm3777 Nuclear pore complexes bind the spindle assembly checkpoint protein MAD1 during interphase, which slows mitotic entry and lowers the threshold for mitotic arrest. PDF Mechanotransduction: Forcing nuclei p220 | doi:10.1038/nrm3780 LINC complex structure and nucleoskeleton organization are key factors in the transmission of mechanical stress to the nucleus. PDF Plant cell biology: Auxin signalling: ABP1 finds its pair p221 | doi:10.1038/nrm3776 The membrane-associated receptor-like kinases TMKs interact with secreted ABP1 to transduce extracellular auxin signals and activate ROP GTPases. PDF Transcription: Splicing keeps RNA polymerase II in check p222 | doi:10.1038/nrm3774 Blocking pre-spliceosome complex formation inhibits transcription elongation on introns in a Cus2p-dependent manner. PDF Cell signalling: Budding GPCRs p223 | doi:10.1038/nrm3770 Ligand-induced shedding of GPCR-containing ectosomes from primary cilia regulates downstream signalling. PDF JOURNAL CLUB A new protein kinase cascade p223 | doi:10.1038/nrm3771 How the activities of AMPK and LKB1 were first observed. PDF IN BRIEF Chromosome biology: H2A.B facilitates transcription | Cell death: At the crossroads of cell death pathways | Metabolism: p66SHC inhibits anabolic metabolism PDF Nature Reviews Molecular Cell Biology JOBS of the week Postdoctoral Fellow - Mammalian Hematopoietic and Erythroid Development The Icahn School of Medicine at Mount Sinai Postdoctoral Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai Postdoctoral Fellow Leidos Biomedical Research, Inc. Postdoctoral Position in Hypoxia Signaling in Cancer ETH Zurich Postdoctoral position in Imaging Lund University More Science jobs from Nature Reviews Molecular Cell Biology EVENT More science events from
REVIEWS		Top
Organization and execution of the epithelial polarity programme Enrique Rodriguez-Boulan & Ian G. Macara p225 | doi:10.1038/nrm3775 The epithelial polarity programme (EPP) is organized in response to extracellular cues and executed through the establishment of an apical–basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insights into the interactions of the EPP with the polarized trafficking machinery and how they regulate epithelial polarization and depolarization. Abstract | Full Text | PDF
Metabolic requirements for the maintenance of self-renewing stem cells Keisuke Ito & Toshio Suda p243 | doi:10.1038/nrm3772 Studies of mouse models and advances in metabolomic analysis, particularly of haematopoietic stem cells, have revealed how metabolic cues from anaerobic glycolysis, bioenergetic signalling, the AKT–mTOR pathway, and Gln and fatty acid metabolism, affect the balance between stem cell self-renewal and differentiation. Understanding how metabolic pathways regulate fate decisions may be beneficial therapeutically. Abstract | Full Text | PDF
Prime movers: the mechanochemistry of mitotic kinesins Robert A. Cross & Andrew McAinsh p257 | doi:10.1038/nrm3768 The detailed motor mechanisms of individual kinesin family members are described in the context of their interactions with dynamic microtubules, and their contributions to important mechanistic events during bipolar spindle assembly and chromosome segregation in animal cells. Abstract | Full Text | PDF
ANALYSIS		Top
The integrin adhesome: from genes and proteins to human disease Sabina E. Winograd-Katz, Reinhard Fässler, Benjamin Geiger & Kyle R. Legate p273 | doi:10.1038/nrm3769 The adhesive interaction of cells with the environment through integrins regulates multiple aspects of cellular physiology. The prominence of gene mutations in specific constituents of integrin-mediated adhesions, which are collectively known as the 'integrin adhesome', in diverse pathological states, is providing insight into the molecular mechanisms that underlie these diseases. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
VIEWPOINT Realizing the potential of synthetic biology George M. Church, Michael B. Elowitz, Christina D. Smolke, Christopher A. Voigt & Ron Weiss p289 | doi:10.1038/nrm3767 Five experts discuss their views on the main achievements and challenges of synthetic biology in basic and applied science, consider potential ethical issues, and describe how synthetic biology relates to disciplines such as systems biology and computational modelling. Abstract | Full Text | PDF
Erratum: A day in the life of the spliceosome A. Gregory Matera & Zefeng Wang p294 | doi:10.1038/nrm3778 Full Text | PDF
Corrigendum: Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth Bruce A. Edgar, Norman Zielke & Crisanto Gutierrez p294 | doi:10.1038/nrm3779 Full Text | PDF
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