Nature Reviews Immunology Contents April 2014 Volume 14 Number 4 pp 209-280

TABLE OF CONTENTS
April 2014 Volume 14 Number 4
Impact Factor 33.129 *	In this issue Research Highlights Correspondence Reviews Perspectives Also this month  Featured article: Leukocyte migration in the interstitial space of non-lymphoid organs Wolfgang Weninger, Maté Biro & Rohit Jain
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RESEARCH HIGHLIGHTS Top Dendritic cells: TLR agonists trigger rapid metabolic changes p209 | doi:10.1038/nri3652 A rapid TLR-induced increase in the rate of glycolysis is crucial for the activation of dendritic cells. PDF Regulatory T cells: Mind control p210 | doi:10.1038/nri3643 IFNβ induces a novel population of FOXA1+ regulatory T cells in the CNS. PDF Antiviral immunity: Editing HLA-E expression p210 | doi:10.1038/nri3647 Human cytomegalovirus infection induces microRNA editing, which leads to decreased HLA-E expression by, and increased NK cell-mediated killing of, infected cells. PDF Innate immune signalling: TIRAP diversifies the sites of TLR signalling p211 | doi:10.1038/nri3645 Promiscuous lipid binding by the sorting adaptor TIRAP regulates TLR signalling from distinct subcellular locations. PDF Tumour immunology: Inflaming tumour spread p212 | doi:10.1038/nri3651 Ultraviolet radiation-induced neutrophilic inflammation promotes melanoma metastasis. PDF Immunogenetics: Tracking immune activity across the genome p212 | doi:10.1038/nri3653 Two new studies link human genetic variants with the innate immune response to infection. PDF Innate lymphoid cells: Support for indie B cells p213 | doi:10.1038/nri3644 Innate lymphoid cells enhance innate-like B cell responses in the spleen. PDF Neutrophils: Nanoparticles targeting the bad guys p214 | doi:10.1038/nri3648 Albumin nanoparticles specifically target activated neutrophils. PDF Inflammation: TNF snuffs out steroids p214 | doi:10.1038/nri3649 Tumour necrosis factor promotes chronic colitis by suppressing intestinal glucocorticoid synthesis. PDF IN BRIEF Neuroimmunology: Electroacupuncture for sepsis | Regulatory T cells: Fingerprinting the peacemakers | MHC molecules: Expanding the detectable peptide repertoire | Myeloid development: Mice with a human innate compartment | HIV: Gene therapy for HIV? | Inflammation: IL-21 stokes brain inflammation PDF Immunology JOBS of the week Faculty Position - Vaccine Immunology Cornell University Post-Doctoral Research Scientist - Molecular Mechanisms of Leukemia Immune Evasion San Raffaele Scientific Institute Postdoc: ER Stress in Arabidopsis Immunity University of Alabama at Birmingham, Dept. of Biology Research Scholar University of North Carolina at Chapel Hill Postdoctoral position in Imaging Lund University More Science jobs from Immunology EVENT Tumor Immunology 01.12.14 Orlando, USA More science events from
REVIEWS		Top
Pathological pain and the neuroimmune interface Peter M. Grace, Mark R. Hutchinson, Steven F. Maier & Linda R. Watkins p217 | doi:10.1038/nri3621 Here, the authors describe the immune mechanisms that are involved in pain, one of the key features of inflammation. They explain how the immune and nervous systems interact to initiate and propagate pain, and discuss the immune components that can be targeted for alleviating pathological pain in patients. Abstract | Full Text | PDF
Leukocyte migration in the interstitial space of non-lymphoid organs Wolfgang Weninger, Maté Biro & Rohit Jain p232 | doi:10.1038/nri3641 This Review follows neutrophils and T cells as they journey from the blood into tissues in search of sites of infection or injury. It highlights the mediators, which form temporally and spatially coordinated gradients within the tissues, and the mechanisms, including physical structures, that guide this directional migration. Abstract | Full Text | PDF
The production and regulation of IgE by the immune system Lawren C. Wu & Ali A. Zarrin p247 | doi:10.1038/nri3632 IgE provides protective immunity against helminths, but is also involved in the pathogenesis of allergic diseases. In this Review, Wu and Zarrin discuss recent studies using different IgE reporter mice, as well as other genetically modified mice, that have provided new insights on the cells and pathways involved in the production and regulation of IgE, and highlight the areas in need of additional studies. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation Andrew D. Wells & Peter A. Morawski p261 | doi:10.1038/nri3625 Three models have been proposed to explain the link between T cell division and differentiation — epigenetic changes, asymmetric division and the direct regulation of gene expression by cell cycle factors. In support of the third model, this Opinion article describes cell cycle-independent roles for the cyclin-dependent kinases as regulators of immunologically relevant transcription factors. Abstract | Full Text | PDF
INNOVATION Democratizing systems immunology with modular transcriptional repertoire analyses Damien Chaussabel & Nicole Baldwin p271 | doi:10.1038/nri3642 Systems biology approaches have revolutionized many fields, including immunology, but analysing and interpreting such large-scale datasets is challenging. Here, the authors describe a novel approach that has been developed to address this issue. It relies on the grouping of co-dependent genes into 'modules', which are then used to build 'fingerprints' that can simplify the analysis of large-scale datasets. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
The sensory immune system: a neural twist to the antigenic discontinuity theory Serge Nataf p280 | doi:10.1038/nri3521-c1 Full Text | PDF
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