Nature Immunology Contents: April 2014 Volume 15 pp 307 - 401

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Advertisement KPL antibodies are high-performing. Our proprietary purification process eliminates potentially interfering serum proteins and non-specific antibodies to deliver a high degree of sensitivity and specificity. Learn more about why this is important to your research.  Download our free Guide to Purification of Polyclonal Antibodies. TABLE OF CONTENTS April 2014 Volume 15, Issue 4 Commentary News and Views Research Highlights Perspective Articles Advertisement   Muse™ Cell Analyzer — Simple, Accurate, Affordable We've miniaturized flow cytometry and packed 3-parameter analysis into a compact, affordable instrument, making quantitative cell analysis accessible to everyone. The system delivers high-performance cell analysis using a microcapillary and miniaturized optics which occupy one-tenth the space of a typical cytometers. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement CALL FOR APPLICATIONS: The 2015 Vilcek Prizes for Creative Promise in Biomedical Science Three $50,000 cash awards for young, foreign-born researchers Learn more about eligibility requirements and apply at Vilcek.org! DEADLINE: June 10, 2014   Advertisement Nature Outlook Vaccines Waging a global battle to prevent disease  Access the Outlook free online for six months. Produced with support from the New Venture Fund, United Nations Children's Fund (UNICEF), and GAVI Alliance, with additional support from the Bill & Melinda Gates Foundation.    Commentary Top Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease   pp307 - 310 Sebastian Zeissig and Richard S Blumberg doi:10.1038/ni.2847 This Commentary discusses how treatment with antibiotics in infancy shapes host immunity and influences susceptibility later in life to diseases mediated by the immune system. News and Views Top POP goes the inflammasome   pp311 - 313 Jayendra Kumar Krishnaswamy, Dong Liu and Stephanie C Eisenbarth doi:10.1038/ni.2848 The PYRIN domain-only protein POP3 sets limits for activation of the AIM2 inflammasome after cytosolic double-stranded DNA is sensed. See also: Article by Khare et al. ILCs in the zone   pp313 - 314 Gabriel D Victora doi:10.1038/ni.2854 Innate lymphoid cells, marginal reticular cells and B cell-helper neutrophils interact to promote antibody secretion by B cells in the marginal zone of the spleen in humans and mice. See also: Article by Magri et al. Glycolytic reprogramming by TLRs in dendritic cells   pp314 - 315 Luke A J O'Neill doi:10.1038/ni.2852 The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells. See also: Article by Everts et al. Coincidence detection of antibodies and interferon for sensing microbial context   pp316 - 317 Marc Daëron and Eric Vivier doi:10.1038/ni.2851 Functional coupling of receptors for immunoglobulin G (FcγRI) and interferon-γ (IFN-γR) generates a context-dependent signaling pathway in macrophages. See also: Article by Bezbradica et al. Immunology JOBS of the week Postdoctoral Position in Immunology at New York University (NYU) New York Langone Medical Center Postdoctoral Scholar - Immunology University of Chicago Faculty Position Human Immunology The Jackson Laboratory PhD in Influenza Immunity University of Kent Postdoctural Associate Duke University Medical Center More Science jobs from Immunology EVENT Tumor Immunology 1st December 2014 Orlando, USA More science events from Research Highlights Top A tolerant response to IFN-β | Neonatal lung | Discrimination power | True adaptor | Balancing fate with Itk | Synchronous signals Perspective Top Vaccines that stimulate T cell immunity to HIV-1: the next step   pp319 - 322 Andrew J McMichael and Wayne C Koff doi:10.1038/ni.2844 Recent findings in the SIV-monkey model provide new evidence that stimulating effective CD8+ T cell immunity could provide protection. McMichael and Koff explore the path forward for optimizing such responses in humans. Articles Top TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation   pp323 - 332 Bart Everts, Eyal Amiel, Stanley Ching-Cheng Huang, Amber M Smith, Chih-Hao Chang et al. doi:10.1038/ni.2833 Activation of dendritic cells induces a metabolic switch from oxidative phosphorylation to glycolysis. Pearce and colleagues show TLR signaling rapidly induces glycolysis by activating a TBK1-IKKε-Akt-HK-II kinase cascade to support the fatty acid synthesis required for the activation of dendritic cells. See also: News and Views by O'Neill A role for the ITAM signaling module in specifying cytokine-receptor functions   pp333 - 342 Jelena S Bezbradica, Rachel K Rosenstein, Richard A DeMarco, Igor Brodsky and Ruslan Medzhitov doi:10.1038/ni.2845 How the generation of outcomes specific to external cues is achieved by a small number of signal-transduction pathways remains unclear. Medzhitov and colleagues describe a mechanism for signal integration based on coupling of the ITAM and Jak-STAT signaling pathways. See also: News and Views by Daeron & Vivier The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses   pp343 - 353 Sonal Khare, Rojo A Ratsimandresy, Lúcia de Almeida, Carla M Cuda, Stephanie L Rellick et al. doi:10.1038/ni.2829 Much is known about the activation of inflammasomes, but less is known about their negative regulation. Stehlik and colleagues demonstrate that the pyrin domain-only protein POP3 negatively regulates inflammasomes involved in sensing DNA. See also: News and Views by Krishnaswamy et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells   pp354 - 364 Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga et al. doi:10.1038/ni.2830 Marginal zone B cells provide rapid antibody responses to blood-borne antigens. Cerutti and colleagues identify a RORγt-dependent innate lymphoid cell subset that establishes crosstalk among multiple cell types to enhance antibody responses. See also: News and Views by Victora Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses   pp365 - 372 Janilyn Arsenio, Boyko Kakaradov, Patrick J Metz, Stephanie H Kim, Gene W Yeo et al. doi:10.1038/ni.2842 How and when memory T cells emerge remains unresolved. Chang and colleagues use single-cell analyses to identify gene-expression signatures predictive of the eventual fates of individual CD8+ T cells during immune responses in vivo. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells   pp373 - 383 Makoto Kurachi, R Anthony Barnitz, Nir Yosef, Pamela M Odorizzi, Michael A DiIorio et al. doi:10.1038/ni.2834 The transcription factor BATF is required for differentiation of certain helper T cell subsets. Haining and colleagues show that BATF crucially regulates CD8+ effector cells by coordinating a transcription factor network. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub   pp384 - 392 Romain Roncagalli, Simon Hauri, Fréderic Fiore, Yinming Liang, Zhi Chen et al. doi:10.1038/ni.2843 TCR ligation triggers the activation of multiple downstream signaling modules. Malissen and colleagues use quantitative proteomics to identify a Lat-independent TCR-CD6-SLP-76-Zap70 signalosome after TCR stimulation. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210   pp393 - 401 Haopeng Wang, Henrik Flach, Michio Onizawa, Lai Wei, Michael T McManus et al. doi:10.1038/ni.2846 Hypoxia stabilizes the transcription factor HIF-1α, which promotes TH17 polarization. Weiss and colleagues show that miR-210 mediates a negative feedback regulatory loop that diminishes HIF-1α abundance under hypoxic conditions. Top Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast: The power of imaging flow cytometry in immunology. Tuesday April 22nd at 8am PDT / 11am EDT / 4pm BST / 5pm CEST  Register for the free webcast followed by a live Q & A session  Sponsored by:     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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