Nature Reviews Molecular Cell Biology contents March 2014 Volume 15 Number 3 pp 1-217

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TABLE OF CONTENTS
March 2014 Volume 15 Number 3
Impact Factor 37.162 *	In this issue Research Highlights Correspondence Progress Reviews Perspectives Also this month Article series: Post-translational modifications  Featured article: Molecular mechanisms of epithelial-mesenchymal transition Samy Lamouille, Jian Xu & Rik Derynck
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RESEARCH HIGHLIGHTS Top Stem cells: Reprogramming with low pH p149 | doi:10.1038/nrm3754 Transient exposure to low pH is sufficient to induce reprogramming to pluripotency. PDF Protein degradation: An alternative route for mitochondrial quality control p150 | doi:10.1038/nrm3755 PINK1 and parkin mediate a mitochondrial quality control mechanism that is independent of canonical mitophagy. PDF Mitosis: Microtubules protect spindle assembly factors p150 | doi:10.1038/nrm3759 The spindle assembly factor HURP is protected from APC/C-targeted degradation by microtubules. PDF In the news p150 | doi:10.1038/nrm3760 The CRISPR-Cas9 system can generate monkeys with targeted gene mutations. PDF Cell migration: Coordinating calcium signalling p152 | doi:10.1038/nrm3761 Directed cell migration requires the coordinated activities of Ca2+, DAG, PMCA and STIM1 in a polarized manner in leader cells. PDF JOURNAL CLUB Shining light on autophagy p153 | doi:10.1038/nrm3751 Our knowledge of autophagy has taken several 'quantum leaps' since the term was coined by Christian de Duve. PDF DNA damage: Dispersing Golgi p153 | doi:10.1038/nrm3762 DNA damage causes dispersal of the Golgi through DNA-PK and GOLPH3. PDF IN BRIEF Cell signalling: Restricting non-canonical NFκB | Cell cycle: Changing lipids | Wound healing: ESCRTs help repair membranes PDF nature molecular cell boilogy JOBS of the week Postdoctoral Fellow in Stem Cell Biology McEwen Centre for Regenerative Medicine/University Health Network Postdoctoral Position in Hematopoietic Stem Cell Biology St. Jude Children's Research Hospital (SJCRH) Director of Cell Biology (JBEI) Lawrence Berkeley National Laboratory (LBNL) 3 Research positions at post-doctoral level Norwegian University of Science and Technology (NTNU) Postdoctoral Fellow Purdue University More Science jobs from nature molecular cell boilogy EVENT More science events from
CORRESPONDENCE		Top
ER-Golgi transport could occur in the absence of COPII vesicles Alexandre A. Mironov p1 | doi:10.1038/nrm3588-c1 Full Text | PDF
ER-Golgi transport: authors' response Federica Brandizzi & Charles Barlowe p1 | doi:10.1038/nrm3588-c2 Full Text | PDF
PROGRESS		Top
Making new contacts: the mTOR network in metabolism and signalling crosstalk Mitsugu Shimobayashi & Michael N. Hall p155 | doi:10.1038/nrm3757 Our understanding of the downstream effectors and upstream regulators of target of rapamycin (TOR) signalling continues to grow. In particular, recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis, and other studies showed that Hippo, WNT and Notch signalling are novel regulators of mTOR. Abstract | Full Text | PDF
REVIEWS		Top
Article series: Post-translational modifications Post-translational modifications of intermediate filament proteins: mechanisms and functions Natasha T. Snider & M. Bishr Omary p163 | doi:10.1038/nrm3753 Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that promote cell integrity and intracellular communication and contribute to subcellular and tissue-specific functions. Our understanding of how post-translational modifications of IF proteins (including nuclear lamins and cytoplasmic keratins, vimentin, desmin, neurofilaments and glial fibrillary acidic protein, among others) regulate IF function is increasing. Abstract | Full Text | PDF
Molecular mechanisms of epithelial–mesenchymal transition Samy Lamouille, Jian Xu & Rik Derynck p178 | doi:10.1038/nrm3758 Epithelial–mesenchymal transition (EMT) is integral to development and pathology. This switch in cell differentiation and behaviour requires key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix–loop–helix transcription factors, and is regulated by several signalling pathways, including those mediated by the transforming growth factor-β (TGFβ) family. Abstract | Full Text | PDF
Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth Bruce A. Edgar, Norman Zielke & Crisanto Gutierrez p197 | doi:10.1038/nrm3756 Endocycling cells successively replicate their genomes without segregating chromosomes during mitosis and thereby become polyploid. Lack of chromosome segregation typically results from downregulation of mitotic cyclin-dependent kinase activity. Endocycles probably evolved many times, and the various endocycle mechanisms found in nature highlight the versatility of the cell cycle control machinery. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Systemic stress signalling: understanding the cell non-autonomous control of proteostasis Rebecca C. Taylor, Kristen M. Berendzen & Andrew Dillin p211 | doi:10.1038/nrm3752 Proteome maintenance was thought to be controlled in a cell-autonomous manner. However, recent findings suggest that proteostasis can be systemically regulated. Protein-folding defects systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues, and this may also coordinate ageing rates between tissues. Abstract | Full Text | PDF
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