Scientific Reports Biology Table of Contents e-alert: 21 January 2014

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21 January 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Reduced erythrocyte deformability associated with hypoargininemia during Plasmodiumfalciparum malaria ▶     Juliana Rey, Pierre A. Buffet, Liliane Ciceron et al.     The mechanisms underlying reduced red blood cell (RBC) deformability during Plasmodium falciparum (Pf) malaria remain poorly understood. Here, we explore the possible involvement …             Visualizing structural dynamics of thylakoid membranes ▶     Masakazu Iwai, Makio Yokono, Akihiko Nakano     To optimize photosynthesis, light-harvesting antenna proteins regulate light energy dissipation and redistribution in chloroplast thylakoid membranes, which involve dynamic …             A new paradigm for transcription factor TFIIB functionality ▶     Vladimir Gelev, Janice M. Zabolotny, Martin Lange et al.     Experimental and bioinformatic studies of transcription initiation by RNA polymerase II (RNAP2) have revealed a mechanism of RNAP2 transcription initiation less uniform across …             A geometrical approach explains Lake Ball (Marimo) formations in the green alga, Aegagropila linnaei ▶     Tatsuya Togashi, Hironobu Sasaki, Jin Yoshimura     An extremely rare alga, Aegagropila linnaei, is known for its beautiful spherical filamentous aggregations called Lake Ball (Marimo). It has long been a mystery in biology as to …             Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay ▶     Agostino Bruno, Francesca Lembo, Ettore Novellino et al.     Cannabinoid type 1 Receptor (CB1) belongs to the GPCR family and it has been targeted, so far, for the discovery of drugs aimed at the treatment of neuropathic pain, nausea, …             Discovery of a Structural-Element Specific G-Quadruplex "Light-Up" Probe ▶     Liyun Zhang, Jun Cheng Er, Krishna Kanta Ghosh et al.     The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel …             ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload ▶     Hirotaka Matsuo, Akiyoshi Nakayama, Masayuki Sakiyama et al.     Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, …             Genetic Influences on Receptive Joint Attention in Chimpanzees (Pan troglodytes) ▶     William D. Hopkins, Alaine C. Keebaugh, Lisa A. Reamer et al.     Despite their genetic similarity to humans, our understanding of the role of genes on cognitive traits in chimpanzees remains virtually unexplored. Here, we examined the …             Multiscale deconstruction of molecular architecture in corn stover ▶     Hideyo Inouye, Yan Zhang, Lin Yang et al.     Lignocellulosic composite in corn stover is a candidate biofuel feedstock of substantial abundance and sustainability. Its utilization is hampered by resistance of constituent …             Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus ▶     Kenkichi Takase, Yuya Sakimoto, Fukuko Kimura et al.     To determine the developmental trajectory of hippocampal function in rats, we examined 24-h changes in extracellular acetylcholine (ACh) levels and contextual learning …             Selenite reduction by Shewanella oneidensis MR-1 is mediated by fumarate reductase in periplasm ▶     Dao-Bo Li, Yuan-Yuan Cheng, Chao Wu et al.     In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution …             A stochastic model dissects cell states in biological transition processes ▶     Jonathan W. Armond, Krishanu Saha, Anas A. Rana et al.     Many biological processes, including differentiation, reprogramming, and disease transformations, involve transitions of cells through distinct states. Direct, unbiased …             TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo ▶     Peter Horak, Erwin Tomasich, Petr Vaňhara et al.     Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in …             Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi ▶     W. Thomas Johnston, Nora Mutalima, David Sun et al.     Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We …             An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models ▶     Jonathan P. Celli, Imran Rizvi, Adam R. Blanden et al.     While it is increasingly recognized that three-dimensional (3D) cell culture models recapitulate drug responses of human cancers with more fidelity than monolayer cultures, a lack …             Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice ▶     Qi-Rui Ong, Elizabeth S. Chan, Mei-Li Lim et al.     Human ApoE4 accelerates memory decline in ageing and in Alzheimer's disease. Although intranasal insulin can improve cognition, this has little effect in ApoE4 subjects. To …             Identification of Three Novel Mutations in the FRMD7 Gene for X-linked Idiopathic Congenital Nystagmus ▶     Xiao Zhang, Xianglian Ge, Ying Yu et al.     Idiopathic congenital nystagmus (ICN) consists of involuntary and periodic ocular motility, often with seriously reduced visual acuity. To identify the genetic defects associated …             Molecular detection of Lactobacillus species in the neovagina of male-to-female transsexual women ▶     Ljubomir Petricevic, Ulrike Kaufmann, Konrad J. Domig et al.     There is a general opinion that penile skin lined neovagina of transsexual women is not able to support the growth of lactobacilli. This study was undertaken to prove if …             Chemical signatures and new drug targets for gametocytocidal drug development ▶     Wei Sun, Takeshi Q. Tanaka, Crystal T. Magle et al.     Control of parasite transmission is critical for the eradication of malaria. However, most antimalarial drugs are not active against P. falciparum gametocytes, responsible for the …             PKA phosphorylation reshapes the pharmacological kinetics of BmK AS, a unique site-4 sodium channel-specific modulator ▶     Z. R. Liu, H. Zhang, J. Q. Wu et al.     Although modulation of the activity of voltage-gated sodium channels (VGSCs) by protein kinase A (PKA) phosphorylation has been investigated in multiple preparations, the …             Network Understanding of Herb Medicine via Rapid Identification of Ingredient-Target Interactions ▶     Hai-Ping Zhang, Jian-Bo Pan, Chi Zhang et al.     Today, herb medicines have become the major source for discovery of novel agents in countermining diseases. However, many of them are largely under-explored in pharmacology due to …             How dolphins see the world: A comparison with chimpanzees and humans ▶     Masaki Tomonaga, Yuka Uwano, Toyoshi Saito     Bottlenose dolphins use auditory (or echoic) information to recognise their environments, and many studies have described their echolocation perception abilities. However, …             Negative Interactions and Feedback Regulations Are Required for Transient Cellular Response ▶     Mohammad Mobashir, Thati Madhusudhan, Berend Isermann et al.     Signal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics …             Experimental and Theoretical Demonstrations for the Mechanism behind Enhanced Microbial Electron Transfer by CNT Network ▶     Xian-Wei Liu, Jie-Jie Chen, Yu-Xi Huang et al.     Bioelectrochemical systems (BESs) share the principle of the microbially catalyzed anodic substrate oxidation. Creating an electrode interface to promote extracellular electron …             Collective behaviour across animal species ▶     Pietro DeLellis, Giovanni Polverino, Gozde Ustuner et al.     We posit a new geometric perspective to define, detect, and classify inherent patterns of collective behaviour across a variety of animal species. We show that machine learning …             Molecular Nanoshearing: An Innovative Approach to Shear off Molecules with AC-Induced Nanoscopic Fluid Flow ▶     Muhammad J. A. Shiddiky, Ramanathan Vaidyanathan, Sakandar Rauf et al.     Early diagnosis of disease requires highly specific measurement of molecular biomarkers from femto to pico-molar concentrations in complex biological (e.g., serum, blood, etc.) …             L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum ▶     Gregory Porras, Philippe De Deurwaerdere, Qin Li et al.     L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links …             Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis ▶     Peng Zhou, Ruth A. Ross, Cameron M. Pywell et al.     To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that …             Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function ▶     Jin Zhou, Jun Chen, Hongyu Sun et al.     Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated …             ERRATUM: Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists ▶     B. Paul-Prasanth, R. K. Bhandari, T. Kobayashi et al.                 Chondroitin Sulfate Is Indispensable for Pluripotency and Differentiation of Mouse Embryonic Stem Cells ▶     Tomomi Izumikawa, Ban Sato, Hiroshi Kitagawa     Chondroitin sulfate (CS) proteoglycans are present on the surfaces of virtually all cells and in the extracellular matrix and are required for cytokinesis at early developmental …             Producing aglycons of ginsenosides in bakers' yeast ▶     Zhubo Dai, Beibei Wang, Yi Liu et al.     Ginsenosides are the primary bioactive components of ginseng, which is a popular medicinal plant that exhibits diverse pharmacological activities. Protopanaxadiol, …             Higher limb asymmetry in deceased human fetuses and infants with aneuploidy ▶     Jessica Bots, Clara M. A. ten Broek, Jeroen A. M. Belien et al.     Aneuploidies cause gene-dosage imbalances that presumably result in a generalized decreased developmental homeostasis, which is expected to be detectable through an increase in …             Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis ▶     Masanori Hiramitsu, Yasuhito Shimada, Junya Kuroyanagi et al.     Lemon (Citrus limon) contains various bioactive flavonoids, and prevents obesity and obesity-associated metabolic diseases. We focused on eriocitrin (eriodictyol 7-rutinoside), a …             An indirect assay for volatile compound production in yeast strains ▶     Davide Ravasio, Andrea Walther, Kajetan Trost et al.     Traditional flavor analysis relies on gas chromatography coupled to mass spectrometry (GC-MS) methods. Here we describe an indirect method coupling volatile compound formation to …             A novel tissue model for angiogenesis: evaluation of inhibitors or promoters in tissue level ▶     Bingling Dai, Yanmin Zhang, Yingzhuan Zhan et al.     A novel tissue model for angiogenesis (TMA) is established for effective evaluation of angiogenesis inhibitors or promoters in vitro. Lung tissues were cultured in fibrinogen …             TEMPRANILLO is a regulator of juvenility in plants ▶     Tiziana Sgamma, Alison Jackson, Rosario Muleo et al.     Many plants are incapable of flowering in inductive daylengths during the early juvenile vegetative phase (JVP). Arabidopsis mutants with reduced expression of TEMPRANILLO (TEM), …             Constant diurnal temperature regime alters the impact of simulated climate warming on a tropical pseudoscorpion ▶     Jeanne A. Zeh, Melvin M. Bonilla, Eleanor J. Su et al.     Recent theory suggests that global warming may be catastrophic for tropical ectotherms. Although most studies addressing temperature effects in ectotherms utilize constant …             Epidemic cholera spreads like wildfire ▶     Manojit Roy, Richard D. Zinck, Menno J. Bouma et al.     Cholera is on the rise globally, especially epidemic cholera which is characterized by intermittent and unpredictable outbreaks that punctuate periods of regional disease …             Graph analysis of dream reports is especially informative about psychosis ▶     Natália B. Mota, Raimundo Furtado, Pedro P. C. Maia et al.     Early psychiatry investigated dreams to understand psychopathologies. Contemporary psychiatry, which neglects dreams, has been criticized for lack of objectivity. In search of …             Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway ▶     Yuqiong Xie, Qiang Li, Qingbo Yang et al.     Gliomas are the most common brain tumors affecting the central nervous system and are associated with a high mortality rate. DCF1 is a membrane protein that was previously found …             Embodied social interaction constitutes social cognition in pairs of humans: A minimalist virtual reality experiment ▶     Tom Froese, Hiroyuki Iizuka, Takashi Ikegami     Scientists have traditionally limited the mechanisms of social cognition to one brain, but recent approaches claim that interaction also realizes cognitive work. Experiments under …             Molecular interaction between natural IgG and ficolin – mechanistic insights on adaptive-innate immune crosstalk ▶     Saswati Panda, Jing Zhang, Lifeng Yang et al.     Recently, we found that natural IgG (nIgG; a non-specific immunoglobulin of adaptive immunity) is not quiescent, but plays a crucial role in immediate immune defense by …             Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering ▶     Shraddha Thakkar, Nisha Nanaware-Kharade, Reha Celikel et al.     Methamphetamine (METH) abuse is a worldwide threat, without any FDA approved medications. Anti-METH IgGs and single chain fragments (scFvs) have shown efficacy in preclinical …             Technical Variations in Low-Input RNA-seq Methodologies ▶     Vipul Bhargava, Steven R. Head, Phillip Ordoukhanian et al.     Recent advances in RNA-seq methodologies from limiting amounts of mRNA have facilitated the characterization of rare cell-types in various biological systems. So far, however, …             Electrical stimulation enhances cell migration and integrative repair in the meniscus ▶     Xiaoning Yuan, Derya E. Arkonac, Pen-hsiu Grace Chao et al.     Electrical signals have been applied towards the repair of articular tissues in the laboratory and clinical settings for over seventy years. We focus on healing of the meniscus, a …             Comprehensive Analysis of GnRH2 Neuronal Projections in Zebrafish ▶     Wei Xia, Olivia Smith, Nilli Zmora et al.     The presence and conservation of GnRH2 across vertebrate species suggest important biological roles. However, the function of GnRH2 remains unclear. A good research model for …             Controlling nitrogen migration through micro-nano networks ▶     Dongqing Cai, Zhengyan Wu, Jiang Jiang et al.     Nitrogen fertilizer unabsorbed by crops eventually discharges into the environment through runoff, leaching and volatilization, resulting in three-dimensional (3D) pollution …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Postdoctoral Scholar     University of California San Francisco (UCSF)            Postdoctoral Researcher     University of Oxford            Research Associate     Cambridge Institute for Medical Research (CIMR)            Postdoctoral Fellowship     Institut du Cerveau et de la Moelle épinière (ICM)            PostDoc     Institut für Ostseeforschung            PhD Student     Max Planck Institute for Molecular Biomedicine            Postdoctoral Fellow     Children's Hosp Phila/University of PA            PhD position     Commissariat à l'Energie Atomique            Postdoctoral Research Scientist     Ohio State University            Research Associate     King's College London          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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