Nature Reviews Microbiology contents February 2014 Volume 12 Number 2 pp 71-148

TABLE OF CONTENTS
February 2014 Volume 12 Number 2
Impact Factor 22.49 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Also this month  Featured article: Type VI secretion system effectors: poisons with a purpose Alistair B. Russell, S. Brook Peterson & Joseph D. Mougous
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EDITORIAL		Top
European report card issued p71 | doi:10.1038/nrmicro3207 The publication of the Annual Epidemiological Report from the ECDC gives a snapshot of the most important communicable disease threats faced by the EU. Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial physiology: Multitasking in Myxococcus p73 | doi:10.1038/nrmicro3202 A new study shows that the Myxococcus xanthus Agl motor protein is modular and can drive spore coat assembly in addition to gliding motility. PDF Viral pathogenesis: HIV-1 adds fuel to the fire p74 | doi:10.1038/nrmicro3201 Two new studies suggest that abortive infection and pyroptosis are main drivers of HIV-1 pathogenesis and might be new targets of host-directed therapeutics. PDF Oomycetes: Attacking the mediator p74 | doi:10.1038/nrmicro3208 The oomycete pathogen Hyaloperonospora arabidopsidis degrades a subunit of the plant Mediator complex to attenuate the salicylic acid response, thus enhancing biotrophy. PDF Microbiome: B. fragilis and the brain p76 | doi:10.1038/nrmicro3197 This proof-of-concept study shows that the gut microbiota is linked to neurodevelopmental disorders via circulating metabolites. PDF Bacterial physiology: Chlamydiae play by their own rules p76 | doi:10.1038/nrmicro3198 Two studies reveal that Chlamydia species possess peptidoglycan-containing cell walls. PDF Bacterial physiology: Remodelling the FtsZ network p77 | doi:10.1038/nrmicro3196 FtsA has a dual role in FtsZ network assembly and rearrangement. PDF IN BRIEF Antimicrobials: Fitness benefits for resistant S. Typhi | Parasite biology: ART resistance marker discovered | Industrial microbiology: Bacterial enzyme fuels CO2 hydrogenation | Viral infection: ɸX174 crosses the border | Cellular microbiology: Getting moving in the cytoplasm | Bacterial secretion: Caught in the act PDF Microbiology JOBS of the week PhD studentship in computational biology and environmental microbiology The James Hutton Institute Postdoctoral Research Trainee -- Microbiology, Immunology & Biochemistry University of Tennessee Health Science Center Post Doctoral Stipend in Co-Infection biology Lund University Post doctoral position on chromatin Centre National de la Recherche Scientifique (CNRS) Postdoctoral Fellow Unversity of Texas Health Science Center at Houston More Science jobs from Microbiology EVENT asm2014: 114th General Meeting of the American Society for Microbiology 17.05.14 Boston, US More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Adding genomic 'foliage' to the tree of life Alan Walker p78 | doi:10.1038/nrmicro3203 This month's Genome Watch highlights recent studies that used metagenomics and single-cell genomics to gain insights into previously uncultivated and poorly characterized microbial lineages. PDF
PROGRESS		Top
Structural and mechanistic insights into prokaryotic energy-coupling factor transporters Dirk J. Slotboom p79 | doi:10.1038/nrmicro3175 Energy-coupling factor transporters mediate the uptake of essential micronutrients in prokaryotes. On the basis of recent structural studies, Dirk Slotboom discusses a testable model for the unusual mechanism of transport that is involved and considers the implications for our understanding of membrane transporters. Abstract | Full Text | PDF
REVIEWS		Top
EF-G and EF4: translocation and back-translocation on the bacterial ribosome Hiroshi Yamamoto, Yan Qin, John Achenbach, Chengmin Li, Jaroslaw Kijek, Christian M. T. Spahn & Knud H. Nierhaus p89 | doi:10.1038/nrmicro3176 In this Review, Nierhaus and colleagues discuss the recent structural and mechanistic insights that have improved our understanding of elongation factor G (EF-G)-mediated forward-translocation and EF-4-mediated back-translocation on the bacterial ribosome. Abstract | Full Text | PDF | Supplementary information
Bacteria-autophagy interplay: a battle for survival Ju Huang & John H. Brumell p101 | doi:10.1038/nrmicro3160 Autophagy not only degrades components of host cells but can also target intracellular bacteria and thus contribute to host defences. Here, Huang and Brumell discuss the canonical and selective pathways of antibacterial autophagy, as well as the ways in which bacteria can escape from them and sometimes even use them to promote infection. Abstract | Full Text | PDF
Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies Dennis Claessen, Daniel E. Rozen, Oscar P. Kuipers, Lotte Søgaard-Andersen & Gilles P. van Wezel p115 | doi:10.1038/nrmicro3178 In this Review, van Wezel and colleagues discuss recent studies that have improved our understanding of the processes that lead to bacterial multicellularity. By considering phylogenetically diverse bacteria, the authors explore the evolutionary and ecological consequences of multicellular behaviour. Abstract | Full Text | PDF
Cell division in apicomplexan parasites Maria E. Francia & Boris Striepen p125 | doi:10.1038/nrmicro3184 Apicomplexan parasites have a complex life cycle that relies on highly regulated development inside host cells. Here, Francia and Striepen give an overview of apicomplexan cell cycle progression and cell division and the ways in which these processes are spatially and temporally guided by the centrosome in these pathogenic parasites. Abstract | Full Text | PDF
Type VI secretion system effectors: poisons with a purpose Alistair B. Russell, S. Brook Peterson & Joseph D. Mougous p137 | doi:10.1038/nrmicro3185 As more type VI secretion systems are identified and the secreted effectors are studied, it is becoming clear that they have an important role in mediating interbacterial interactions. Although the focus has mainly been on antagonistic interactions, type VI secretion systems may have physiological roles that extend beyond antagonism. Mougous and colleagues review the microbial ecology of type VI secretion, including a potential role in modulating microbial community dynamics. Abstract | Full Text | PDF
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