Nature Reviews Genetics Contents February 2014 Volume 15 Number 2 pp 63-141

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TABLE OF CONTENTS
February 2014 Volume 15 Number 2		Advertisement
Impact Factor 41.063 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Modes of transcriptional regulation Disease mechanisms  Featured article: Pluripotent stem cells in regenerative medicine: challenges and recent progress Viviane Tabar & Lorenz Studer	The easiest NGS Library preparation you will ever find!    •  Quick 3-step protocol         without transfers   •  Picogram inputs   •  Perfect compatibility        with ChIP/ChIP-seq        samples down to 10,000      cells  Learn more about Diagenode's MicroChIP and MicroPlex kits.
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Nature Methods METHOD OF THE YEAR: SINGLE-CELL SEQUENCING Nature Methods presents a series of articles that report the unique considerations related to sequencing single cells and their recent exciting applications in biology and medicine. Access the METHOD OF THE YEAR and METHODS TO WATCH by visiting: www.nature.com/nmeth/focus/moy2013
RESEARCH HIGHLIGHTS Top Genetic therapies: Correcting genetic defects with CRISPR-Cas9 p63 | doi:10.1038/nrg3656 PDF Microbial genetics: Fitness from drug resistance p64 | doi:10.1038/nrg3658 PDF Evolution: An eye for cryptic variation p64 | doi:10.1038/nrg3660 PDF Gene regulation: Translation steps up to a regulatory role p64 | doi:10.1038/nrg3661 PDF Plant genomics: A genome conserved and a genome expanded p66 | doi:10.1038/nrg3657 PDF Epigenetics: Reprogramming with TET p66 | doi:10.1038/nrg3659 PDF IN BRIEF Systems biology: Metabolically constrained regulatory networks | Epigenetics: Mapping occluded genes | Molecular evolution: Evolving demands on tRNAs | Small RNAs: Insights into siRNA-triggered heterochromatin | Disease genetics: Genetic diagnoses from single oocytes | Technology: Mapping small-molecule binding sites | Enhancers: BRD4 and JMJD6 regulate antipause enhancers | RNA: Characterizing native RNA structures PDF Genetics JOBS of the week Postdoc Position: Evolutionary Biology: Gene Network Models and Evolution University of Helsinki Research Scientist I - Gene Expression Division New England Biolabs Postdoctoral Fellow in Epigenetics University of Pennsylvania Postdoc Position - Cancer Bioinformatics VIB Center for the Biology of Disease, K.U.Leuven Postdoctoral research scholar University of Iowa More Science jobs from Genetics EVENT Zebrafish Development and Genetics 10.08.14 Woods Hole, USA More science events from
REVIEWS		Top
Dynamic regulation of transcriptional states by chromatin and transcription factors Ty C. Voss & Gordon L. Hager p69 | doi:10.1038/nrg3623 To regulate gene expression, transcription factors must access DNA, which is organized in chromatin. This occurs on many timescales; in this Review, the authors discuss the mechanisms that underlie this interaction in regulated and stochastic processes. Abstract | Full Text | PDF
Pluripotent stem cells in regenerative medicine: challenges and recent progress Viviane Tabar & Lorenz Studer p82 | doi:10.1038/nrg3563 The derivation of disease-relevant cell types from pluripotent stem cells holds much promise for disease therapy. The recent progress in directed differentiation and the challenges ahead are discussed in this Review. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Chromatin modifiers and remodellers: regulators of cellular differentiation Taiping Chen & Sharon Y. R. Dent p93 | doi:10.1038/nrg3607 This Review describes the diverse roles for histone-modifying and chromatin-remodelling enzymes in mammalian differentiation. These enzymes are involved in both maintaining pluripotency and specifying cell lineage commitment. Recent progress includes their functional characterization in mouse models in vivo and a new appreciation of their multifaceted molecular functions. Abstract | Full Text | PDF
Constraint-based models predict metabolic and associated cellular functions Aarash Bordbar, Jonathan M. Monk, Zachary A. King & Bernhard O. Palsson p107 | doi:10.1038/nrg3643 Constraint-based modelling methods systematize biochemical, genetic and genomic knowledge into a mathematical framework, which enables a mechanistic description of metabolic physiology. Recent successes in using this approach have implications for microbial evolution, interaction networks, genetic engineering and drug discovery. Abstract | Full Text | PDF
Sequencing depth and coverage: key considerations in genomic analyses David Sims, Ian Sudbery, Nicholas E. Ilott, Andreas Heger & Chris P. Ponting p121 | doi:10.1038/nrg3642 Methods that are based on next-generation sequencing technology are used for a range of applications from genome sequencing to transcriptomic and epigenomic studies. Here, the authors discuss the important issue of sequencing depth in the design of such experiments. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Disease mechanisms The role of de novo mutations in the genetics of autism spectrum disorders Michael Ronemus, Ivan Iossifov, Dan Levy & Michael Wigler p133 | doi:10.1038/nrg3585 In the past few years, there have been rapid advances in the identification of the genetic components of autism spectrum disorders, particularly in the form of de novo mutations. Here, the authors review these developments in light of genetic models for autism spectrum disorders. Abstract | Full Text | PDF
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