Nature Immunology Contents: February 2014 Volume 15 pp 111 - 205

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TABLE OF CONTENTS February 2014 Volume 15, Issue 2 Focus Editorial Commentary Reviews News and Views Research Highlights Articles Resource Errata Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook Cancer Immunotherapy New treatments enhance natural defences to fight malignancy  Access the Outlook free online for six months. Produced with support of a medical education grant from Bristol-Myers Squibb and with support of a grant from Dendreon Corp., F. Hoffmann-La Roche Ltd and Merck & Co., Inc.   Focus Top Focus on High-dimensional immune analysis Contents Editorial Commentary Review New technologies enable analysis of the extraordinarily diverse and polymorphic components of the immune system-especially the human immune system-at a level of unprecedented detail. A series of Reviews and Commentaries specially commissioned by Nature Biotechnology and Nature Immunology discuss these new methodologies, and how they may be applied to track immune status in health and disease, as well as to reveal new basic immunological insight. A Correspondence describing an initiative to design tools and resources to facilitate these high-dimensional analyses is also included. Editorial Top Focus on High-dimensional immune analysis New dimensions in immunology   p111 doi:10.1038/ni.2809 Emerging technologies are broadening our understanding of the human immune system, but capitalizing on their application will likely require philosophical and practical changes to the way research is done. Commentary Top Focus on High-dimensional immune analysis Quantitative shotgun proteomics: considerations for a high-quality workflow in immunology   pp112 - 117 Felix Meissner and Matthias Mann doi:10.1038/ni.2781 Proteomics based on high-resolution mass spectrometry has become a powerful tool for the analysis of protein abundance, modifications and interactions. Here we describe technical aspects of proteomics workflows, instrumentation as well as computational considerations to obtain high-quality proteomics data. Reviews Top Focus on High-dimensional immune analysis Unifying immunology with informatics and multiscale biology   pp118 - 127 Brian A Kidd, Lauren A Peters, Eric E Schadt and Joel T Dudley doi:10.1038/ni.2787 Dudley and colleagues review some of the computational analysis tools for high-dimensional data and how they can be applied to immunology. Focus on High-dimensional immune analysis Single-cell technologies for monitoring immune systems   pp128 - 135 Pratip K Chattopadhyay, Todd M Gierahn, Mario Roederer and J Christopher Love doi:10.1038/ni.2796 Love and colleagues review the limitations of bulk measurements for monitoring the immune system and explore advances in single-cell technologies that overcome these problems. News and Views Top TCR signaling: the barrier within   pp136 - 137 Michael L Dustin and Simon J Davis doi:10.1038/ni.2811 Acute inhibition of the regulatory kinase Csk reveals additional checkpoints for full activation of thymocytes via the T cell antigen receptor. See also: Article by Tan et al. Old HDL learns a new (anti-inflammatory) trick   pp138 - 139 Justin I Odegaard and Ajay Chawla doi:10.1038/ni.2798 In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor. See also: Article by De Nardo et al. Strength in numbers: comparing vaccine signatures the modular way   pp139 - 141 W Nicholas Haining doi:10.1038/ni.2807 Gene-expression signatures of the human vaccine response can be complex and noisy. Li et al. develop a new collection of gene-expression modules and use it to compare the response to five different vaccines. See also: Resource by Li et al. Immunology JOBS of the week Assistant / Associate Professor of Immunology and Infectious Diseases Harvard School of Public Health (HSPH) Researcher in Immunology and Cell Biology Virginia Commonwealth University Postdoctoral Research Fellow in Immunology & Hemostaseology University Medical Center - Mainz Post-doctoral position in Allergy and Immunology University of Southern California More Science jobs from Immunology EVENT Ita Askonas: Sixty Years in Immunology 7th April 2014 London, UK More science events from Research Highlights Top Aging B cell repertoires | Virus-induced autophagy | In vivo role for Vpr | A cold wake-up call for immunity | Muscle Treg cells | Mucus specificity Articles Top Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2   pp143 - 151 Patricia R Taylor, Sanhita Roy, Sixto M Leal Jr, Yan Sun, Scott J Howell et al. doi:10.1038/ni.2797 IL-17 production by neutrophils has been reported in human psoriasis. Pearlman and colleagues identify a population of neutrophils that constitutively express the transcription factor RORγt and can produce and respond to IL-17A. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3   pp152 - 160 Dominic De Nardo, Larisa I Labzin, Hajime Kono, Reiko Seki, Susanne V Schmidt et al. doi:10.1038/ni.2784 High-density lipoprotein (HDL) has beneficial effects in coronary artery disease. Latz and colleagues show that HDL's benefits stem at least in part by activating an anti-inflammatory program dependent on the transcription factor ATF3. See also: News and Views by Odegaard & Chawla Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation   pp161 - 167 Bryan Vander Lugt, Aly A Khan, Jason A Hackney, Smita Agrawal, Justin Lesch et al. doi:10.1038/ni.2795 Dendritic cell (DC) subsets show functional specialization. Singh and colleagues demonstrate that the transcription factor IRF4 enhances antigen presentation by MHC class II in CD11b+ DCs to promote the priming of CD4+ effector T cells. STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling   pp168 - 176 Andreas Begitt, Mathias Droescher, Thomas Meyer, Christoph D Schmid, Michelle Baker et al. doi:10.1038/ni.2794 Transcriptional complexes can polymerize and bind adjacent binding sites. Vinkemeier and colleagues show that STAT1 cooperativity is required downstream of type 2 interferonsignaling but not for type 1 interferon-induced immune responses. CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens   pp177 - 185 Annemieke de Jong, Tan-Yun Cheng, Shouxiong Huang, Stephanie Gras, Richard W Birkinshaw et al. doi:10.1038/ni.2790 CD1a-autoreactive T cells are common in human skin, but their natural antigens have remained unknown. De Jong and colleagues show that apolar oils that naturally accumulate in epidermis and sebum nest within CD1a and are activatory. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling   pp186 - 194 Ying Xim Tan, Boryana N Manz, Tanya S Freedman, Chao Zhang, Kevan M Shokat et al. doi:10.1038/ni.2772 The kinase Csk inhibits basal TCR signaling. Weiss and colleagues reveal a requirement for CD28 costimulation upon Csk inhibition for facilitation of actin remodeling and activation of signaling pathways downstream of the phospholipase PLC-γ1. See also: News and Views by Dustin & Davis Resource Top Molecular signatures of antibody responses derived from a systems biology study of five human vaccines   pp195 - 204 Shuzhao Li, Nadine Rouphael, Sai Duraisingham, Sandra Romero-Steiner, Scott Presnell et al. doi:10.1038/ni.2789 Pulendran and colleagues use a systems biology analysis to reveal distinct transcriptional signatures of antibody responses to different classes of human vaccines. See also: News and Views by Haining Corrigenda Top Corrigendum: B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen   p205 Irene Puga, Montserrat Cols, Carolina M Barra, Bing He, Linda Cassis et al. doi:10.1038/ni0214-205a Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells   p205 Kamalakannan Rajasekaran, Pawan Kumar, Kristina M Schuldt, Erik J Peterson, Bart Vanhaesebroeck et al. doi:10.1038/ni0214-205b Errata Top Erratum: The role of the immune system in governing host-microbe interactions in the intestine   p205 Eric M Brown, Manish Sadarangani and B Brett Finlay doi:10.1038/ni0214-205d Erratum: Matching cellular dimensions with molecular sizes   p205 Michael Reth doi:10.1038/ni0214-205c Top Advertisement Nature Immunology & Nature Biotechnology  FOCUS ON HIGH-DIMENSIONAL IMMUNE ANALYSIS  Nature Biotechnology and Nature Immunology present a series of specially commissioned articles discussing new technologies and approaches that enable more detailed and comprehensive analysis of the immune system.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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