The EDGE

AAV Empty Capsids: For Better or for Worse?

J Fraser Wright

Mol Ther 2014 22: 1-2; 10.1038/mt.2013.268

In This Issue

In this issue

Mol Ther 2014 22: 4; 10.1038/mt.2013.269

Research Highlights

Research Highlights

Mol Ther 2014 22: 5; 10.1038/mt.2013.270

Commentaries

Giving Oncolytic Vaccinia Virus More BiTE

Steven M Albelda and Steve H Thorne

Mol Ther 2014 22: 6-8; 10.1038/mt.2013.271

Combining Drugs and Biologics to Treat Nasopharyngeal Cancer

Helen E Heslop

Mol Ther 2014 22: 8-9; 10.1038/mt.2013.272

Original Articles

AAV-mediated Liver-specific MPV17 Expression Restores mtDNA Levels and Prevents Diet-induced Liver Failure

Emanuela Bottani, Carla Giordano, Gabriele Civiletto, Ivano Di Meo, Alberto Auricchio, Emilio Ciusani, Silvia Marchet, Costanza Lamperti, Giulia d’Amati, Carlo Viscomi and Massimo Zeviani

Mol Ther 2013 22: 10-17; advance online publication, July 3, 2013; 10.1038/mt.2013.230

Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

Christel Devaud, Jennifer A Westwood, Liza B John, Jacqueline K Flynn, Sophie Paquet-Fifield, Connie PM Duong, Carmen SM Yong, Hollie J Pegram, Steven A Stacker, Marc G Achen, Trina J Stewart, Linda A Snyder, Michele WL Teng, Mark J Smyth, Phillip K Darcy and Michael H Kershaw

Mol Ther 2013 22: 18-27; advance online publication, September 19, 2013; 10.1038/mt.2013.219

AAV8 Induces Tolerance in Murine Muscle as a Result of Poor APC Transduction, T Cell Exhaustion, and Minimal MHCI Upregulation on Target Cells

Lauren E Mays, Lili Wang, Jianping Lin, Peter Bell, Alison Crawford, E John Wherry and James M Wilson

Mol Ther 2013 22: 28-41; advance online publication, June 19, 2013; 10.1038/mt.2013.134

CD8⁺ T Cell Recognition of Epitopes Within the Capsid of Adeno-associated Virus 8–based Gene Transfer Vectors Depends on Vectors’ Genome

Te-Lang Wu, Hua Li, Susan M Faust, Emily Chi, Shangzhen Zhou, Fraser Wright, Katherine A High and Hildegund CJ Ertl

Mol Ther 2013 22: 42-51; advance online publication, September 30, 2013; 10.1038/mt.2013.218

No Impact of Lentiviral Transduction on Hematopoietic Stem/Progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model

Stephanie E Sellers, Bogdan Dumitriu, Mary J Morgan, William M. Hughes, Colin O Wu, Nalini Raghavarchari, Yanqin Yang, Naoya Uchida, John F Tisdale, Dong S An, Irvin S Chen, Peiman Hematti, Robert E Donahue, Andre LaRochelle, Neal S Young, Rodrigo T Calado and Cynthia E Dunbar

Mol Ther 2013 22: 52-58; advance online publication, July 18, 2013; 10.1038/mt.2013.168

Transduction of Fetal Mice With a Feline Lentiviral Vector Induces Liver Tumors Which Exhibit an E2F Activation Signature

Reba Condiotti, Daniel Goldenberg, Hilla Giladi, Temima Schnitzer-Perlman, Simon N Waddington, Suzanne MK Buckley, Denise Heim, Wing Cheung, Matthew Themis, Charles Coutelle, Alina Simerzin, Emma Osejindu, Henning Wege, Michael Themis and Eithan Galun

Mol Ther 2013 22: 59-68; advance online publication, August 28, 2013; 10.1038/mt.2013.193

Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles

Hamed Laroui, Duke Geem, Bo Xiao, Emilie Viennois, Poonam Rakhya, Timothy Denning and Didier Merlin

Mol Ther 2013 22: 69-80; advance online publication, September 12, 2013; 10.1038/mt.2013.214

In Vitro and In Vivo Efficacy of SYL040012, a Novel siRNA Compound for Treatment of Glaucoma

Tamara Martínez, Maria Victoria González, Ingo Roehl, Natalia Wright, Covadonga Pañeda and Ana Isabel Jiménez

Mol Ther 2013 22: 81-91; advance online publication, September 12, 2013; 10.1038/mt.2013.216

Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo^MTOPEN

Henryk Dudek, Darren H Wong, Rokhand Arvan, Anee Shah, Kathleen Wortham, Bo Ying, Rohan Diwanji, Wei Zhou, Benjamin Holmes, Hailin Yang, Wendy A Cyr, Yi Zhou, Aalok Shah, Ruchir Farkiwala, Michael Lee, Yiting Li, Garrett R Rettig, Michael A Collingwood, Sujit K Basu, Mark A Behlke and Bob D Brown

Mol Ther 2013 22: 92-101; advance online publication, October 3, 2013; 10.1038/mt.2013.233

T-cell Engager-armed Oncolytic Vaccinia Virus Significantly Enhances Antitumor Therapy

Feng Yu, Xingbing Wang, Z Sheng Guo, David L Bartlett, Stephen M Gottschalk and Xiao-Tong Song

Mol Ther 2013 22: 102-111; advance online publication, October 17, 2013; 10.1038/mt.2013.240

Sindbis Viral Vectors Transiently Deliver Tumor-associated Antigens to Lymph Nodes and Elicit Diversified Antitumor CD8⁺ T-cell Immunity

Tomer Granot, Yoshihide Yamanashi and Daniel Meruelo

Mol Ther 2013 22: 112-122; advance online publication, September 12, 2013; 10.1038/mt.2013.215

Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy

Samuel T Workenhe, Graydon Simmons, Jonathan G Pol, Brian D Lichty, William P Halford and Karen L Mossman

Mol Ther 2013 22: 123-131; advance online publication, October 9, 2013; 10.1038/mt.2013.238

Adoptive T-cell Transfer and Chemotherapy in the First-line Treatment of Metastatic and/or Locally Recurrent Nasopharyngeal Carcinoma^MTOPEN

Whay-Kuang Chia, Marissa Teo, Who-Whong Wang, Bernett Lee, Soo-Fan Ang, Wai-Meng Tai, Chit-Lai Chee, Joanna Ng, Rebecca Kan, Wan-Teck Lim, Sze-Huey Tan, Whee-Sze Ong, Yin-Bun Cheung, Eng-Huat Tan, John E Connolly, Stephen Gottschalk and Han-Chong Toh

Mol Ther 2013 22: 132-139; advance online publication, October 17, 2013; 10.1038/mt.2013.242

Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors

Irina V Balyasnikova, Melanie S Prasol, Sherise D Ferguson, Yu Han, Atique U Ahmed, Margarita Gutova, Alex L Tobias, Devkumar Mustafi, Esther Rincón, Lingjiao Zhang, Karen S Aboody and Maciej S Lesniak

Mol Ther 2013 22: 140-148; advance online publication, September 3, 2013; 10.1038/mt.2013.199

Exploiting Human CD34⁺ Stem Cell–conditioned Medium for Tissue Repair^MTOPEN

Paul J Mintz, Kai-Wen Huang, Vikash Reebye, Georgios Nteliopoulos, Hong-Shiee Lai, Pal Sætrom, Noriyuki Kasahara, Steen Jensen, Madhava Pai, Myrtle YA Gordon, Stephen B Marley, Rosemary Behan, Duncan R Spalding, Abdelali Haoudi, Mohamed M Emara, Joanna Nicholls, John J Rossi and Nagy A Habib

Mol Ther 2013 22: 149-159; advance online publication, August 28, 2013; 10.1038/mt.2013.194

Serial Transplantation and Long-term Engraftment of Intra-arterially Delivered Clonally Derived Mesenchymal Stem Cells to Injured Bone Marrow

Paul Lin, Diego Correa, Thomas J Kean, Amad Awadallah, James E Dennis and Arnold I Caplan

Mol Ther 2013 22: 160-168; advance online publication, September 25, 2013; 10.1038/mt.2013.221

Platelet Gene Therapy by Lentiviral Gene Delivery to Hematopoietic Stem Cells Restores Hemostasis and Induces Humoral Immune Tolerance in FIX^null Mice

Yingyu Chen, Jocelyn A Schroeder, Erin L Kuether, Guowei Zhang and Qizhen Shi

Mol Ther 2013 22: 169-177; advance online publication, August 23, 2013; 10.1038/mt.2013.197

Cardiac Progenitor Cells Engineered With βARKct Have Enhanced β-Adrenergic Tolerance

Mohsin Khan, Sadia Mohsin, Haruhiro Toko, Monique Alkatib, Jonathan Nguyen, Silvia Truffa, Natalie Gude, Kurt Chuprun, Douglas G. Tilley, Walter J. Koch and Mark A. Sussman

Mol Ther 2013 22: 178-185; advance online publication, September 3, 2013; 10.1038/mt.2013.200

Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure

Chia-Hsin Lu, Tsung-Szu Yeh, Chia-Lin Yeh, Yu-Hua Dean Fang, Li-Yu Sung, Shih-Yeh Lin, Tzu-Chen Yen, Yu-Han Chang and Yu-Chen Hu

Mol Ther 2013 22: 186-195; advance online publication, July 15, 2013; 10.1038/mt.2013.165

Genetic Vaccine for Respiratory Syncytial Virus Provides Protection Without Disease Potentiation

Teresa R Johnson, David Rangel, Barney S Graham, Douglas E Brough and Jason G Gall

Mol Ther 2013 22: 196-205; advance online publication, June 10, 2013; 10.1038/mt.2013.142

Immunotherapy-induced CD8⁺ T Cells Instigate Immune Suppression in the Tumor

A J Robert McGray, Robin Hallett, Dannie Bernard, Stephanie L Swift, Ziqiang Zhu, Florentina Teoderascu, Heather VanSeggelen, John A Hassell, Arthur A Hurwitz, Yonghong Wan and Jonathan L Bramson

Mol Ther 2013 22: 206-218; advance online publication, October 23, 2013; 10.1038/mt.2013.255

Autologous Myoblast Transplantation for Oculopharyngeal Muscular Dystrophy: a Phase I/Iia Clinical Study

Sophie Périé, Capucine Trollet, Vincent Mouly, Valérie Vanneaux, Kamel Mamchaoui, Belaïd Bouazza, Jean Pierre Marolleau, Pascal Laforêt, Françoise Chapon, Bruno Eymard, Gillian Butler-Browne, Jérome Larghero and Jean Lacau St Guily

Mol Ther 2013 22: 219-225; advance online publication, July 8, 2013; 10.1038/mt.2013.155

Phase I Clinical Trial of SYL040012, a Small Interfering RNA Targeting β-Adrenergic Receptor 2, for Lowering Intraocular Pressure

Javier Moreno-Montañés, Belén Sádaba, Verónica Ruz, Almudena Gómez-Guiu, Javier Zarranz, María Victoria González, Covadonga Pañeda and Ana Isabel Jimenez

Mol Ther 2013 22: 226-232; advance online publication, September 12, 2013; 10.1038/mt.2013.217

Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses

Richard D Antrobus, Tamara K Berthoud, Caitlin E Mullarkey, Katja Hoschler, Lynda Coughlan, Maria Zambon, Adrian VS Hill and Sarah C Gilbert

Mol Ther 2013 22: 233-238; advance online publication, July 8, 2013; 10.1038/mt.2013.162